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acinar cell Carcinoma of the Pancreas

Chinese Journal of Clinical Oncology 2008年第4期5卷 235-241页

作者： Hua Li Qiang Li Department of Endoscopy Tianjin Medical Uni versity Cancer Institute ＆ Hospital Tianjin 300060. China Department of Hepatobiliary Surgery Tianjin Medical Uni versity Cancer Institute ＆ Hospital Tianjin 300060. China.

acinar cell carcinoma of the pancreas is a rare tumor which is defined as a carcinoma that exhibits pancreatic enzyme production by neoplastic *** review includes re- cent developments in our understanding of the epidemiology and pathogenesis of ACC,imaging and pathological diagnosis and ap- proaches to treatment with reference to the literature.

关键词： carcinoma acinar cell pancreas.

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Inhibition of cathepsin B protects pancreatic acinar cells against apoptosis in early pancreatic trauma in rats

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Emergency and Critical Care Medicine 2022年第1期2卷 7-11页

作者： Cong Feng Lili Wang Jingyang Peng Xiang Cui Xuan Zhou Department of Emergency First Medical Center of Chinese PLA General HospitalBeijingChina Department of General Medicine First Medical Center of Chinese PLA General HospitalBeijingChina Department of Radiology First Medical CenterGeneral Hospital of the PLABeijingChina Department of Orthopedics Fourth Medical CenterGeneral Hospital of the PLABeijingChina Department of Emergency Hainan Hospital of Chinese PLA General HospitalSanyaChina

Objectives:To observe the protective effect of cathepsin B inhibition against apoptosis of acinar cells in the early management of pancreatic contusion and laceration in rats,which would provide evidence of a potential early therapeutic for pancreatic contusion and ***:Twenty-four rats were assigned to 2 groups:1)Model(n=12)with an induced pancreatic injury of severity I-II and 2)CA074-V(n=12):an induced pancreatic injury,severity I-II treated with the cathepsin B inhibitor CA074-me(0.01mg/g)by intravenous administration through the caudal vein at 5minutes post model *** mice in these two groups were further randomly divided into 4 subgroups containing 3 rats each that were sacrificed for quantitation of apoptosis,immunohistochemistry of cathepsin B,and serum amylase and lipase measurements at different time points after model establishment(0,3,6,and 12hours).Results:The percentage of apoptotic pancreatic acinar cells collected from the injured tissues were much lower in the CA074-V group than the Model group at 3hours[9.25±3.94%vs.64.76±26.47%,Pacinar cells were much lower in the CA074-V group than in the Model group at 3hours[31.07±12.02%vs.69.16±5.71%,Pacinar cell apoptosis in an experimental rat model of pancreatic contusion and laceration.

关键词： acinar cell Apoptosis Cathepsin B inhibition Pancreatic contusion and laceration

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Acute pancreatitis:pathogenesis and emerging therapies

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Journal of Pancreatology 2024年第1期7卷 10-20页

作者： Saif Zaman Fred Gorelick Department of Internal Medicine Yale School of MedicineNew HavenCT 06511 Veteran’s Administration Healthcare System West HavenCT 06516 Department of cell Biology Yale School of MedicineNew HavenCT 06511

Acute pancreatitis is a severe inflammatory disorder with limited treatment *** understanding of disease mechanisms has led to new and potential *** we summarize what we view as some of the most promising new therapies for treating acute pancreatitis,emphasizing the rationale of specific treatments based on disease *** pharmacologic interventions are *** explore potential treatment benefits and risks concerning reducing acute injury,minimizing complications,and improving long-term *** associated with acute pancreatitis initiation,perpetuation,and reconstitution are highlighted,along with potential therapeutic targets and how these relate to new treatments.

关键词： acinar cell Acute pancreatitis Calcium signaling Transporters Treatment

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