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N-acetylcysteine attenuates alcohol-induced oxidative stess in rats

World Journal of Gastroenterology 2003年第4期9卷 791-794页

作者： Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk Department of Infectious Diseases and Clinical Microbiology University of IstanbulIstanbulTurkey Department of Internal Medicine University of IstanbulIstanbulTurkey Department of Biochemistry University of IstanbulIstanbulTurkey

AIM:To investigate free-radical scavenger effect of n- acetylcysteine in rats intragastrically fed with ethanol. METHODS:Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day,Group 1),ethanol and n- acetylcysteine (1 g/kg,Group 2),or isocaloric dextrose (control group,Group 3) for 4 *** animals were sacrificed under ether anesthesia,and intracardiac blood and liver tissues were *** were made in both serum and homogenized liver tissues. Malondialdehyde (MDA) level was measured by TBARS *** peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits. Kruskal-Wallis test was used for statistical analysis. RESULTS:ALT and AST in Group 1 (154 U/L and 302 U/L, respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 for both).Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein) and Group 3 (0.94 nmol/ml and 49 nmol/100 mg-protein) (P<0.001 for both).On the other hand,serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2 (16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001).Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26 U/100 rag-protein) were lower than that in Group 2 (18 U/ mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 rag-protein) (P<0.001 for both). CONCLUSION:Ethanol-induced liver damage was associated with oxidative stress,and co-administration of n-acetylolsteine attenuates this damage effectively in rat model.

关键词： acetylcysteine Alanine Transaminase Animals Aspartate Aminotransferases Ethanol inhibitors Glutathione Glutathione Peroxidase Liver Male Malondialdehyde Oxidative Stress Rats Rats, Wistar Research Support, Non-U.S. Gov't Superoxide Dismutase

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N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat

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World Journal of Gastroenterology 2003年第1期9卷 125-128页

AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative *** aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ***: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver *** (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial ***-Wallis test was used for statistical ***: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P＝0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P＜0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P＜0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P＜0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model.

关键词： Oxidative Stress acetylcysteine Animals Erythrocytes Ethanol dosage Free Radical Scavengers Glutathione Glutathione Peroxidase Lipid Peroxidation Liver Male Rats Rats, Wistar Research Support, Non-U.S. Gov't Superoxide Dismutase Thiobarbituric Acid Reactive Substances

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Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

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World Journal of Clinical Cases 2024年第18期12卷 3482-3490页

作者： Li-Yuan Huang Bin Huang Zheng Lv Xiao-Dan Lu Department of Integration of Traditional Chinese and Western Medicine School of Clinical MedicineChangchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Infectious Diseases Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Zoology School of Life SciencesChangchun Normal UniversityChangchun 130032Jilin ProvinceChina Precision Medical Center Jilin Province General HospitalChangchun 130021Jilin ProvinceChina

BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and *** traditional Chinese medicine,AECOPD is linked to phlegm-heat and blood-stasis,presenting symptoms like thick sputum,fever,and chest *** has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD,suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type *** To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type *** One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two *** treatment group received acetylcysteine inhalation(10%solution,5 mL,twice daily)along with conventional therapy,whereas the control group received only conventional *** treatment duration was 14 *** markers(C-reactive protein,interleukin-6,and tumor necrosis factor-alpha)in the serum and sputum as well as lung function parameters(forced expiratory volume in one second,forced vital capacity,and peak expiratory flow)were assessed pre-and *** inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group(Pacetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type *** acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control *** differences were statistically significant(P

关键词： Acute exacerbation Chronic obstructive pulmonary disease Traditional Chinese medicine acetylcysteine Phlegm-heat and blood-stasis Lung ventilation function

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Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects

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Acta Pharmacologica Sinica 2006年第3期27卷 259-272页

作者： Irena MANOV Helen MOTANIS Idan FRUMIN Theodore C IANCU Pediatric Research and Electron Microscopy Unit.Ruth and Baruch Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa Israel

With the increasing incidence of drug-induced liver disease,attempts are beingmade to better understand the mechanisms behind these frequently life-endan-gering *** and anti-inflammatory drugs are a major group ex-hibiting *** review research relating to these reactions,focusingon ultrastructural findings,which may contribute to the comprehension and pos-sible avoidance of drug-induced liver *** also present some originalobservations on clinical material and cultured cells exposed to acetaminophenalone or in combination with the antioxidant N-acetylcysteine or the P-glycopro-tein inhibitor verapamil.

关键词： non-steroidal anti-inflammatory agents drug toxicity liver aspirin acetaminophen cultured cells electron microscopy apoptosis P-glycoprotein acetylcysteine

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N-acetyl cysteine therapy in acute viral hepatitis

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World Journal of Gastroenterology 2003年第12期9卷 2698-2700页

作者： Huseyin Gunduz Oguz Karabay Ali Tamer Resat zaras Ali Mert mer Fehmi Tabak Department of Internal Medicine and Cordiology Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Infectious Diseases and Clinical Microbiology Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Internal Medicine Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Infectious Diseases and Clinical Microbiology Cerrahpasa Medical FacultyIstanbul UniversityFindikzade/lstanbulTurkey

AIM: To investigate the effect of N-acetyl cysteine (NAC)on acute viral hepatitis (AVH).METHODS: We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group. All patients were hospitalized and diagnosed as AVH. Blood total and direct bilirubin, ALT, AST,alkaline phosphatese, albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl, ALT level under 100 U/L, follow up was continued and then the patients were ***: A total of 41(13 female and 28 male) AVH patients were included in our study. The period for normalization of ALT and total bilirubin in the study group was 19.7±6.9 days and 13.7±8.5 days respectively. In the control group it was 20.4±6.5 days and 16.9±7.8 days respectively (P＞0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.

关键词： acetylcysteine Acute Disease Adolescent Adult Alanine Transaminase Antiviral Agents Aspartate Aminotransferases Bilirubin Comparative Study Female Hepatitis A Hepatitis B Humans Liver Function Tests Male Middle Aged Reference Values

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N-AcetyI-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-κB activation in alveolar macrophages by different mechanisms

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Acta Pharmacologica Sinica 2006年第3期 339-346页

作者： Ya-qing LI Zhen-xiang ZHANG~1 Yong-jian XU Wang NI Shi-xin CHEN Zhao YANG Dan MA Department of Respiratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030.China

Aim:To study the effects of N-acetyl-L-cysteine(NAC)and pyrrolidine dithio-carbamate(PDTC)on the phosphorylation of IκB kinase(IKK)β,IKKα,and IλBαin alveolar macrophages(AM),and to explore the pharmacological mechanisms ofNAC and PDTC as inhibitors of NF-κB ***:AM were collectedfrom bronchoalveolar lavage fluid from the patients with chronic obstructive pul-monary *** AM were incubated for 1.5 h with NAC and PDTC,and thenstimulated for 90 min by either tumor necrosis factor(TNF)-α or interleukin(IL)-*** blotting was used to detect the protein phosphorylation levels of IKKβ,IKKα,and IκBα.NF-κB activity was analyzed by using an electrophoretic mobil-ity shift ***:NAC inhibited the phosphorylation of IKKβ,IKKα,andIκBα induced by TNF-α,but had no effect on the phosphorylation of IKKβ,IKKαand IκBα induced by *** did not inhibit the phosphorylation of IκBαinduced by TNF-α or ***,NAC inhibited the activation of NF-κBinduced by TNF-α,but had no effect on the activation of NF-κB induced by *** significantly inhibited the activation of NF-κB induced by TNF-α and *** electrophoretic mobility shift assay also showed that PDTC and NAC do notdirectly inhibit NF-κB DNA binding activity in ***:PDTC preventsthe degradation of IκBα via the ubiquitylation-proteasome proteolytic *** can inhibit the processes upstream of IKK activation induced by TNF-α,which results in the decline of NF-κB activity.

关键词： NF-kappa B acetylcysteine pyrrolidine dithiocarbamic acid alveolar macrophage

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Intraductalpapillarymucinousneoplasmofthebileductwithgastricand duodenalfistulas

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World Journal of Gastrointestinal Endoscopy 2014年第7期6卷 70-76,78+337-338页

作者： Hong MY Yu DW Hong SG Man Yong Hong Dong Wook Yu Seung Goun Hong Department of Internal Medicine SAM Anyang Hospital Gyeonggi 430-733 South Korea

Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowl-edge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stom-ach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fis-tula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into cho-ledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledocho-gastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The pa-tient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved af-ter percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d.

关键词： Intraductal papillary mucinous neoplasm Bile duct Fistula acetylcysteine

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