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Possibility of “Comet-Like” Transport of acetylcholine Receptors in Command <i>Helix</i>Neurons in Cellular Analog of Habituation

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World Journal of Neuroscience 2014年第2期4卷 133-143页

作者： Arkady S. Pivovarov Galina B. Murzina Denis A. Makhnovsky Mariya S. Tret’yakova Department of Higher Nervous Activity Faculty of Biology Moscow Lomonosov State University Moscow Russia Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences Moscow Russia

The presence of "comet-like" radial transport of acetylcholine receptors by actin microfilaments without the participation of myosin motors in the depression of acetylcholine-induced inward chloric current (ACh-current) in command neurons of defensive behavior of the land snail, Helix lucorum, in a cellular analog of habituation was investigated. For that purpose the effects of CK548, CK-636 (inhibitors of actin-related protein complex Arp2/3, whose activation triggers rapid actin polymerization and the formation of the "comet-like" tail on the actinic filament) and wiskostatin (an N-WASP protein inhibitor, activating Arp2/3) on the depression of ACh-current were studied. The attenuation of ACh-current depression was observed upon the addition of CK548. At the same time, CK-636 and wiskostatin irreversibly strengthened the depression of this current and suppressed its spontaneous recovery. The results of CK-548 action and its mathematical modeling allow suggesting the presence of "comet-like" transport of acetylcholine receptors, initiated by Arp2/3 protein complex in receptor endo and exocytosis in command neurons of Helix lucorum in a cellular analog of habituation. Irreversible inhibition of vital metabolic processes of the neuron by wiskostatin and CK-636, which lead to the decrease in the level of ATP, could have caused irreversible effects of these blockers on current depression.

关键词： CK-548 CK-636 Wiskostatin Depression of acetylcholine-induced Inward Current Command Neurons Helix lucorum Cellular Analog of Habituation

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