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Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up

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Bioactive Materials 2022年第11期7卷 439-456页

作者： Barzi Gareb Nico Bvan Bakelen Leon Driessen Pieter Buma Jeroen Kuipers Dirk W.Grijpma Arjan Vissink Ruud R.M.Bos Baucke van Minnen University of Groningen University Medical Center GroningenDepartment of Oral and Maxillofacial SurgeryHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands Radboud University Medical Center Radboud Institute for Molecular Life SciencesOrthopaedic Research LabHoutlaan 46525 XZP.O.Box 91026500 HCNijmegenthe Netherlands University of Groningen University Medical Center GroningenDepartment of Biomedical Sciences of Cells and SystemsHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands University of Twente TechMed CentreDepartment of Biomaterials Science and TechnologyDrienerlolaan 57522 NBP.O.Box 2177500 AEEnschedethe Netherlands

pplying biodegradable osteosyntheses avoids the disadvantages of titanium osteosyntheses. However, foreign-body reactions remain a major concern and evidence of complete resorption is lacking. This study compared the physico-chemical properties, histological response and radiographs of four copolymeric biodegradable osteo-synthesis systems in a goat model with 48-months follow-up. The systems were implanted subperiosteally in both tibia and radius of 12 Dutch White goats. The BioSorb FX [poly(70LLA-co-30DLLA)], Inion CPS [poly([70–78.5] LLA-co-[16–24]DLLA-co-4TMC)], SonicWeld Rx [poly(DLLA)], LactoSorb [poly(82LLA-co-18GA)] systems and a negative control were randomly implanted in each extremity. Samples were assessed at 6-, 12-, 18-, 24-, 36-, and 48-month follow-up. Surface topography was performed using scanning electron microscopy (SEM). Differential scanning calorimetry and gel permeation chromatography were performed on initial and explanted samples. Histological sections were systematically assessed by two blinded researchers using (polarized) light microscopy, SEM and energy-dispersive X-ray analysis. The SonicWeld Rx system was amorphous while the others were semi-crystalline. Foreign-body reactions were not observed during the complete follow-up. The SonicWeld Rx and LactoSorb systems reached bone percentages of negative controls after 18 months while the BioSorb Fx and Inion CPS systems reached these levels after 36 months. The SonicWeld Rx system showed the most predictable degradation profile. All the biodegradable systems were safe to use and well-tolerated (i.e., complete implant replacement by bone, no clinical or histological foreign body reactions, no [sterile] abscess formation, no re-interventions needed), but nanoscale residual polymeric fragments were observed at every system’s assessment.

关键词： Biocompatible materials absorbable implants Polymers Orthopaedic fixation devices Reconstructive surgical procedures Fracture fixation

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Observation on 105 Cases of Duodenal Bulbar Ulcer Treated by Combined Therapy of Catgut Embe0ding and Chinese Drugs

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Journal of Traditional Chinese Medicine 2001年第2期21卷 111-115页

作者：范兆金 Acupuncture Department The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou510405

Duodenal bulbar ulcer is a frequently encountered disease. Clinically, it manifests itself by regular epigastric pain accompanied by belching and acid regurgitation, corresponding to epigastralgia and stomach distending pain in traditional Chinese medicine (TCM). Based on the TCM type-differentiation, the author has treated 105 cases of duodenal bulbar ulcer by the combined therapy of catgut embedding at point Zusanli (ST 36) and Chinese drugs with satisfactory results. A summary is as follows. Clinical Data1. Case selection: The cases selected all had the clinical symptoms and signs of duodenal bulbar ulcer, and had been diagnosed by GI examination at this or other hospitals with no obvious therapeutic effects obtained after relevant treatment, and still symptoms and signs and repeated attacks of pain.

关键词： absorbable implants Adult Catgut Drugs, Chinese Herbal Duodenal Ulcer Female Humans Male Middle Aged

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Catgut Point-Embedding Therapy in Treatment of 76 Cases of Ulcerative Colitis

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Journal of Traditional Chinese Medicine 2001年第2期21卷 116-117页

作者：肖冠峰周桂荣 Xuchang Municipal Hospital of Traditional Chinese Medicine Henan Province461000

In recent years, our department has adopted a catgut point-embedding therapy in the treatment of 76 cases of chronic ulcerative colitis, with quite good therapeutic effects. The following is a report of it.Clinical DataOf 76 cases we treated, 32 were male, and 44 female, with the ages ranging from 23 to 65 years and the duration of illness from 6 months to 20 years.All the cases complained of chronic diarrhea, most of them had mucous and blood stool, and some had tenesmus. Sigmoscopic findings showed that all the cases had varying degrees of colic mucosal congestion and edema, fragile mucosa easy to bleed upon touching, or rough mucosa with multiple ulcers varying in size, shape, and depth.

关键词： Acupuncture Points absorbable implants Adult Aged Catgut Colitis, Ulcerative Female Humans Male Middle Aged

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Treatment of displaced radial head fractures by internal fixation with absorbable pins

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Chinese Journal of Traumatology 2006年第6期9卷 356-358页

作者：侯振海周继红施建国史毅斌夏俊杰姚军 Department of Orthopaedic Trauma 117th Hospital of PLAHangzhou 310004China Institute for Traffic Medicine Research Institute of SurgeryDaping HospitalChongqing 400042China

Objective： To study the effect of internal fixation with absorbable pins on treatment of displaced radial head fractures. Methods： From May 1999 to May 2004, 16 patients with displaced radial head fractures （Mason types Ⅱ and Ⅲ） were treated with internal fixation by absorbable pins. The duration of follow-up averaged 22.6 months （12-58 months）. The outcome was assessed on the basis of elbow motion, radiographic findings and the functional rating score delineated by Broberg and Morrey. Results： All fractures healed within 10 months without avascular necrosis of radial head. The mean elbow flexion loss was 15°（0°-35°） , and pronation and supination decreased by 10°（ 0°-30°） on average compared with those of the contralateral elbow. Five patients had an excellent result, 6 a good result, and 3 a fair result according to the criteria of Borberg and Morrey. Conclusions： Internal fixation with absorbable pins is an effective method in treating displaced radial head fractures. It can maintain the biomechanical stability of forearm, improve the elbow function and avoid second operation.

关键词： Radius Radius fractures Fracture fixation, internal absorbable implants

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