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Use of absorbable meshes in laparoscopic paraesophageal hernia repair

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World Journal of Gastrointestinal Surgery 2019年第10期11卷 388-394页

作者： Bernabé M Quesada Adelina E Coturel Department of Surgery Cosme Argerich Hospital

Paraesophageal hernia(PEH)repair is one of the most challenging upper gastrointestinal operations.Its high rate of recurrence is due mostly to the low quality of the crura and size of the hiatal defect.In an attempt to diminish the recurrence rates,some clinical investigators have begun performing meshreinforced cruroplasty with nonabsorbable meshes like polypropylene or polytetrafluoroethylene.The main problem with these materials is the occurrence,in some patients,of serious mesh-related morbidities,such as erosions into the stomach and the esophagus,some of which necessitate subsequent esophagectomy or gastrectomy.absorbable meshes can be synthetic or biological and were introduced in recent years for PEH repair with the intent of diminishing the recurrence rates observed after primary repair alone but,theoretically,without the risks of morbidities presented by the nonabsorbable meshes.The current role of absorbable meshes in PEH repair is still under debate,since there are few data regarding their long-term efficacy,particularly in terms of recurrence rates,morbidity,need for revision,and quality of life.In this opinion review,we analyze all the presently available evidence of reinforced cruroplasty for PEH repair using nonabsorbable meshes(synthetic or biological),focusing particularly on recurrence rates,mesh-related morbidity,and long-term quality of life.

关键词： Paraesophageal hernia Laparoscopy Mesh absorbable Biological

Application Potential of Mg–Zn–Nd Alloy as a Gastrointestinal Anastomosis Nail Material

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 609-620页

作者： Lihui Song Ming Gao Lili Tan Zheng Ma Peng Ni Min Zhou Di Na Department of Surgical Oncology and General Surgery The First Hospital of China Medical UniversityKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110001China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Gastrointestinal tumors are common malignant tumors in the digestive tract, of which gastric cancer is the third leading cause of cancer death and colorectal cancer is the fourth most deadly cancer. Nowadays, surgical resection remains to be one of the main measures for treating digestive tract tumors, and gastrointestinal anastomosis remains to be a key step in gastrointestinal surgery. Mg and its alloys have great potentials to be used for gastrointestinal anastomosis as anastomotic nail materials due to their biodegradability, good mechanical properties and biocompatibility. In this study, Mg–2Zn–0.5Nd(ZN20) alloy fine wires showed great potential as surgical staples. When we performed in vitro corrosion experiments, drainage fluid was collected from different parts of the patient’s abdominal cavity after surgery for the first time to replace the traditional simulation fluid and to more realistically simulate the microenvironment required by the anastomotic nail. ZN20 alloy has an ultimate tensile strength of 256 MPa, an elongation rate of 12.56%, a tensile force in anastomosis of 16.8 N, and a rupture pressure after anastomosis at 17 kPa, which means that a sufficient mechanical support was provided after anastomosis.The statistical analysis and histopathological analysis of biochemical tests indicate that ZN20 alloy has no adverse effect on the normal metabolism of liver, kidney and body, but has superior biocompatibility and biosafety. This work confirms that ZN20 possesses a great application potential in the clinical field as a new type of gastrointestinal anastomotic nail material.

关键词： Magnesium alloy Gastrointestinal tumor absorbable Degradation rate

Intracranial pressure monitoring in neurosurgery:the present situation and prospects

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Chinese Neurosurgical Journal 2023年第3期9卷 212-223页

作者： Chenqi He Chubei Teng Zujian Xiong Xuelei Lin Hongbo Li Xuejun Li Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008People’s Republic of China Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research Xiangya HospitalCentral South UniversityChangshaHunan 410008People’s Republic of China Department of Neurosurgery the First Affiliated HospitalUniversity of South ChinaHengyangHunan 421001People’s Republic of China

Intracranial pressure(ICP)is one of the most important indexes in neurosurgery.It is essential for doctors to determine the numeric value and changes of ICP,whether before or after an operation.Although external ventricular drainage(EVD)is the gold standard for monitoring ICP,more and more novel monitoring methods are being applied clinically.Invasive wired ICP monitoring is still the most commonly used in practice.Meanwhile,with the rise and development of various novel technologies,non-invasive types and invasive wireless types are gradually being used clinically or in the testing phase,as a complimentary approach of ICP management.By choosing appropriate monitoring methods,clinical neurosurgeons are able to obtain ICP values safely and effectively under particular conditions.This article introduces diverse monitoring methods and compares the advantages and disadvantages of different monitoring methods.Moreover,this review may enable clinical neurosurgeons to have a broader view of ICP monitoring.

关键词： ICP Cerebrospinal fluid Zero drift Wireless telemetering absorbable Non-invasive

Synthetic absorbable Surgical Sutures

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Journal of China Textile University(English Edition) 1999年第1期16卷 59-65页

作者：于建明

This paper reviewed all types of the polymer - based synthetic absorbable surgical sutures that have been commercially produced. The chemical component, biological and mechanical properties, and using effect of these sutures were discussed. The recent development and the possible coming research orientation in these areas were also presented.

关键词： synthetic absorbable sutures’, poly ( glycolic acid) polylactide polydioxanone poly(glycolide -co - tri-methylene carbonate) poly(glycolide -co - caprolactone) .

Utility of C-Reactive Protein and Procalcitonin for Detecting Bloodstream Infection in Patients with HIV/AIDS

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World Journal of AIDS 2014年第3期4卷 287-292页

作者： Arianna Castillo Marshall Tersilia García Castellanos Isabel Martínez Motas Daniel Salazar Rodriguez María Eugenia Toledo Romaní Jorge Pérez ávila Clinical Laboratory International Health Center La Pradera La Havana Cuba Department of Clinical Microbiology Institute of Tropical Medicine “Pedro Kourí” La Havana Cuba Epidemiology Research Department Institute of Tropical Medicine “Pedro Kourí” La Havana Cuba Institute of Tropical Medicine “Pedro Kourí” La Havana Cuba Medicine Faculty Latin-American’s School La Havana Cuba

Human immunodeficiency virus (HIV) infected persons, are at high risk for developing a bloodstream infection. In order to evaluate the usefulness of C-reactive protein (CRP) and procalcitonin (PTC) in the detection of bloodstream infection in HIV, a case-control study was conducted from February to December 2012. PCT and CPR levels were measured in 2 groups. PCT concentrations were measured by the VIDAS®?Brahms PCT assay, and CRP concentrations were determined by CRP latex. Values were calculated for both biomarkers and discriminative ability of PCT and CRP was analyzed using ROC curves. There were no significant differences between the study group and the control groups with respect to CRP levels. However, they were much higher PCT levels in patients with bacteremia. PCT showed greater discriminating ability compared to CRP, and proved to be a valuable tool for the detection of systemic bacterial infections in HIV infected patients.

关键词： Acute Renal Injury Surgical Hemostasis absorbable Implants Inflammation Biocompatible

Biopolymer Sponge for High Grade Renal Trauma: An Experimental Study in Rabbits

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Open Journal of Urology 2014年第1期4卷 1-6页

作者： Leandro H. M. Tavares Fábio O. Vilar José L. Aguiar Alexandre R. Paz Francisco A. D. Melo Gustavo R. P. Negromonte Department of Surgery Federal University of Paraiba University Hospital Lauro Wanderley Joao Pessoa Brazil Department of Surgery Federal University of Pernambuco Clinics Hospital Recife Brazil

Introduction: Acute blunt or open renal trauma sometimes requires conservative measure which involves the use of specific materials in order to adequately restore renal parenchima. The purpose of this study is to analyze the effects of the sugar cane biopolymer sponge in an experimental model of renal trauma in rabbits. Methods: Experimental prospective study was paired with twelve New Zealand rabbits. After induction of renal trauma bilateral high-grade (grade 4-collecting system, according to AAST), the sugar cane biopolymer sponge was used for homeostasis and reconstruction of the right renal parenchyma (experimental group). The same procedure was performed in the left kidney, but using the Surgifoam? sponge (Control Group). The animals were sacrificed after four weeks. Histological analysis was performed and the results were compared after statistically being evaluated. Results: Comparing the experimental group with the control, there was more inflammatory reaction and premature adhesions in the first one. Concerning the influence on efficacy and biocompatibility of the biopolymer, no serious complications like massive bleeding, haematoma, fistula or urinary stone formation were found in both groups. Conclusion: The sugar cane biopolymer sponge demonstrated good efficacy in relation to hemostatic control and reconstruction of the renal parenchyma without major complications. Future studies may direct its routine use in urologic practice.

关键词： Acute Renal Injury Surgical Hemostasis absorbable Implants Inflammation Biocompatible Materials