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Efficacy and Tolerability of Thermocoagulation Treatment of High-Grade Cervical Intraepithelial Neoplasia

Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1691-1710页

作者： Beatriz Maykot Kuerten Paulo Sérgio Viero Naud Francisco Jose Cidral-Filho Armando José D’Acampora Department of Obstetrics and Gynecology Federal University of Santa Catarina Florianópolis Brazil Department of Obstetrics and Gynecology Federal University of Rio Grande do Sul Porto Alegre Brazil Experimental Neuroscience Laboratory (LaNEx) Postgraduate Program in Health Sciences University of Southern Santa Catarina Florianópolis Brazil Department of Clinical Surgery Federal University of Santa Catarina Florianópolis Brazil

Purpose: Cervical cancer is still one of the main causes of cancer and mortality in women, especially in low- and middle-income countries, although it is a completely preventable disease through the detection and treatment of pre-cancer lesions. We evaluated the efficacy and tolerability of thermocoagulation treatment of high-grade cervical intraepithelial neoplasia (CIN 2 and 3). Methods: We evaluated 115 women with high-grade cervical intraepithelial neoplasia, 54 with CIN 2 and 61 with CIN 3, confirmed by biopsy and without previous treatment, from January 2016 to December 2018, undergoing thermocoagulation treatment at the Lower Genital Tract Pathology and Colposcopy Service of the Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. Results: The mean age was 33.11 years (SD = 9.83) for CIN 2 and 35.28 years (SD = 7.97) for CIN 3 patients. Treatment efficacy was 90.8% in CIN 2 and 94.9% in CIN 3 cases. Pain was the main symptom reported at the time of treatment, occurring more frequently in the CIN 3 group (49.1% versus 27.8% in the CIN 2 group). As the more important long-term complication, there were 3 cases of pelvic inflammatory disease in CIN 2 (5.6%) and 3 in CIN 3 group (5.0%). The percentage of residual lesion was very low in both groups, 5 in CIN 2 group (9.2%) and 2 in CIN 3 g

关键词： Cervical Intraepithelial Neoplasia Thermocoagulation Efficacy Results ablation procedures Cancer Prevention

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