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Pharmacological Prospects of Oxygenated abietane-Type Diterpenoids from <i>Taxodium distichum</i>Cones

Advances in Biological Chemistry 2014年第2期4卷 109-115页

作者： Norihisa Kusumoto Nobuhiro Aburai Tatsuya Ashitani Koetsu Takahashi Ken-ichi Kimura Institute of Wood Technology Akita Prefectural University Noshiro Japan The United Graduate School of Agricultural Sciences Iwate University Morioka Japan

Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.

关键词： abietane Diterpenoid Conifer Cone Antibacterial Activity 17α-Hydroxylase/C17 20-Lyase Prolyl Oligopeptidase Cytotoxicity

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Three New Diterpenoids from Euphorbia wallichii

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Chinese Journal of Chemistry 2004年第2期22卷 199-202页

作者：王环张晓峰蔡祥海马云保罗晓东 Northwest Institute of Plateau Biology Chinese Academy of Sciences Xining Qinghai 810001 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming Yunnan 650204 China

Three new abietane diterpene lactones, 3-hydroxyjolkinolide A (1), ent-8,14-dihydroxy-13(15)-ene-16(12)- abietanolide (2) and ent-8,14-dihydroxy-13(15)-ene-16(12)-abietanolide (3) as well as a known abietane diter-pene jolkinolide A (4) were isolated from the roots of Euphorbia wallichii. Their structures were elucidated on the basis of spectroscopic analysis.

关键词： Euphorbia wallichii Euphorbiaceae abietane 3?hydroxyjolkinolide A ent-8 14-dihydroxy- 13(15)-ene-16(12)-abietanolide 14-dihydroxy-13(15)- ene-16(12)-abietanolide

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A New Diterpene from Suregada glomerulate(Blume) Baill

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Chinese Chemical Letters 2005年第6期16卷 786-788页

作者： SuLiHE RuoYunCHEN InstituteofMateriaMedica ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100050

A new diterpene with an abietane skeleton, 3β-hydroxy-8α, 14α-epoxyabieta-11, 13(15)-dien-16,12-olide, was isolated from the root of Suregada glomerulate(Blume) Baill. Its structure was elucidated on the basis of s... 详细信息

关键词： Suregada glomerulate(Blume) Baill diterpene abietane 3β-hydroxy-8α,14α-epoxy- abieta-11,13 (15)-dien-16,12-olide X-ray crystallographic analysis.

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Antihyperglycemic effect of Juniperus phoenicea *** alloxan-induced diabetic rats and diterpenoids isolated from the fruits

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Journal of Coastal Life Medicine 2015年第11期 906-909页

作者： Salma Ahmed El-Sawi Hemaia Mohamed Motawae Abdel-Rahman Omar El-Shabrawy Mohamed Aboul-Fotouh Sleem Amani Ameen Sleem Maii Abdel Naby Ismail Maamoun Pharmacognosy Department National Research CentreCairoEgypt Pharmacognosy Department Faculty of PharmacyCairo UniversityCairoEgypt Pharmacology Department National Research CentreCairoEgypt

Objective:To explore the traditional use of Juniperus phoenicea L.(***)growing in Egypt as antidiabetic ***:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture *** a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer ***:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(Pabietane ***,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of *** growing in *** identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the ***:It has become clear that leaves and fruits of the Egyptian *** provide effective antihyperglycemic action in diabetic rats as was reported in folk *** high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.

关键词： Juniperus phoenicea Antihyperglycemic abietane Labdane Diterpenoid

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