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World Journal of Gastroenterology 2017年第20期23卷 3758-3760页

作者： Marie-Philippe Harvey Alain Watier émilie Dufort Rouleau Guillaume Léonard Research Centre on Aging Universitéde Sherbrooke Department of Gastroenterology Sherbrooke University Hospital Centre Department of Pharmacy Sherbrooke University Hospital Centre School of Rehabilitation University of Sherbrooke

Chronic abdominal and pelvic pain is a common condition that has significant impact on quality of life,and causes billions of dollars in direct and indirect *** data suggest that transcranial direct current stimulation(t DCS),alone or in combination with transcutaneous electrical nerve stimulation(TENS),could be a promising therapeutic avenue to reduce chronic *** encouraging results coming from these studies prompted us to try combining TENS and t DCS in 4 of our patients who suffered from chronic abdominal/pelvic pain and to compare the effect with 5other patients who received TENS *** intensity was assessed with a visual analog scale before,during and after the *** observed that there was a slight decrease in pain which was similar in both patient groups(TENS alone and TENS combined with t DCS).These observations suggest that combining TENS and t DCS in patients suffering from chronic pelvic and/or abdominal pain produces no additional benefit,compared to TENS *** studies,looking at the effect of several/consecutive TENS and t DCS sessions should be conducted.

关键词： Transcranial direct current stimulation Transcutaneous electrical nerve stimulation Pelvic pain abdominal pain Chronic pain

Symptoms and Their Interpretation in Patients Self-Treating abdominal Cramping and pain with a Spasmolytic(Butylscopolamine Bromide)—A Pharmacy-Based Survey

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Pharmacology & Pharmacy 2011年第2期2卷 82-87页

作者： Stefan Müller-Lissner Eckhard Schafer Anke Kondla Park-Klinik Weissensee Charite-Universitatsmedizin BerlinGermany Boehringer Ingelheim IngelheimGermany

Background: A majority of people suffering from functional abdominal complaints treat themselves with OTC medication. Aim: To gain information on symptoms and their interpretation in patients self-treating abdominal cramping and pain with a spasmolytic (butylscopolamine). Method: 4,680 questionnaires were distributed by 306 pharmacists in Germany to patients suffering from abdominal complaints and buying butylscopolamine. Key findings: Questionnaires from 1,539 respondents were returned, and 1,417 could be evaluated. abdominal cramping was the major reason for buying butylscopolamine. Only a minority of respondents had consulted a general practitioner (27.3%) and even less a specialist (12.5%). Only a minority of subjects met expert criteria for irritable bowel syndrome (13%). There was a large overlap between self-reported dysmenorrhoea and bowel symptoms (35%). Conclusions: Real life conditions do not seem to be well covered by expert criteria. Differentiating bowel origin from uterine origin in pelvic pain syndromes seems especially problematic. This may particularly apply to the OTC market.

关键词： abdominal pain Butylscopolamine Bromide Irritable Bowel Syndrome(IBS) Dysmenorrhoea

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer abdominal pain Thrombocythemia Colonoscopy Case report

Primaryomental torsionina 12-year-old boy

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Chinese Medical Journal 2001年第2期114卷 90-91页

作者：曹文刚张金哲 China 100045

Primany omental torsion (POT), known since 1899, is a disease that usually occurs in the fourth and fifth decades of life. Men are affected twice as frequently as women, with the majority being overweight.1　It is a r... 详细信息

关键词： Omentum abdominal pain Appendicitis Child Diagnosis Differential Humans Male Peritoneal Diseases Torsion

Irritable bowel syndrome: A microbiome-gut-brain axis disorder?

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World Journal of Gastroenterology 2014年第39期20卷 14105-14125页

作者： Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke 1.15 Biosciences Institute Department of Psychiatry Alimentary Pharmabiotic Centre University College Cork Cork Ireland Department of Anatomy and Neuroscience Alimentary Pharmabiotic CentreUniversity College CorkCork Ireland

Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions.

关键词： Irritable bowel syndrome Microbiome Anxiety Tryptophan abdominal pain Gastrointestinal motility Cognition

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity abdominal pain

Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation

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World Journal of Gastroenterology 2022年第22期28卷 2509-2522页

作者： Florian Mourey Amélie Decherf Jean-François Jeanne Mathieu Clément-Ziza Marie-Lise Grisoni François Machuron Sophie Legrain-Raspaud Arnaud Bourreille Pierre Desreumaux Research and Applications Department Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France Data Science and Bioinformatics Laboratory Research and Development DepartmentLesaffre InternationalLesaffre GroupMarcq-en-Baroeul 59700France Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de NantesNantes 44093France Institute for Translational Research in Inflammation Centre Hospitalier Universitaire de LilleLille 59000France

BACKGROUND Probiotics are a promising solution for managing irritable bowel syndrome(IBS).Saccharomyces cerevisiae(***)I-3856 has already demonstrated beneficial effects in IBS subjects,particularly in IBS with predominant constipation(IBS-C).AIM To confirm the efficacy of *** I-3856 in the management of gastrointestinal symptoms in *** A randomized,double-blind,placebo-controlled clinical study was performed in a total of 456 *** a run-in period,subjects were randomly assigned to the group receiving *** I-3856(8×109 CFU daily)or the placebo for 8 wk,and they performed daily self-evaluations of gastrointestinal *** primary objective was to assess the effect of the probiotic on abdominal *** secondary objectives were the evaluation of other gastrointestinal symptoms,bowel movement frequency and consistency,and quality of life(QOL).RESULTS A significantly higher proportion of abdominal pain responders was reported in the Probiotic group(45.1%vs 33.9%,P=0.017).A nonsignificant difference in the area under the curve for abdominal pain over the second month of supplementation was observed in subjects receiving probiotic vs placebo[P=0.073,95%CI:-0.59(-1.23;0.05)].No statistically significant differences were reported in the evolution of bowel movement frequency and stool consistency between the *** 8 wk of supplementation,the overall QOL score was significantly higher in the Probiotic group than in the Placebo group[P=0.047,95%CI:3.86(0.52;7.20)].Furthermore,exploratory analyses showed statistically significant and clinically relevant improvements in QOL scores in abdominal pain responders vs *** The results of this clinical study confirmed the abdominal pain alleviation properties of *** I-3856 in *** pain relief was associated with improved *** identifier:NCT03150212.

关键词： Probiotic Yeast Saccharomyces cerevisiae Irritable bowel syndrome abdominal pain Quality of life

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

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World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang Zhi-Hua Xu Shuang-Shuang Ni Hong-Xia Luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract abdominal pain Acoustic contrast agent

High risk of temporomandibular disorder in irritable bowel syndrome: Is there a correlation with greater illness severity?

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World Journal of Gastroenterology 2017年第1期23卷 103-109页

作者： Serena Gallotta Vincenzo Bruno Santo Catapano Nicola Mobilio Carolina Ciacci Paola Iovino Functional GI Disorders Center at Gastrointestinal Unit AOU S. Giovanni di Dio e Ruggi d’Aragona Department of Medicine and Surgery University of Salerno Dental School University of Ferrara

AIMTo investigate the prevalence and the risk of temporomandibular disorders (TMDs) in patients with irritable bowel syndrome (IBS) (including each subtype: constipation, diarrhoea, and mixed) compared to the general *** January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls (HC) without IBS. At enrollment, we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for *** enrolled 91 IBS patients (23 IBS-D, 30 IBS-C and 38 IBS-M) and 57 HC in the study. We found a higher risk of having TMD (OR = 3.41, 95%CI: 1.66-7.01) compared to the HC. The risk of having TMD was independent of IBS-subtype. Multiple regression analysis showed that facial pain was positively related to abdominal pain and higher level of *** patients had a more than three times greater risk of TMD compared to HC. The risk of having TMD was similar in different IBS subtypes. IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance.

关键词： Temporomandibular disorders Irritable bowel syndrome Chronic pain Facial pain abdominal pain Irritable bowel syndrome severity score symptoms Irritable bowel syndrome predominant diarrhea Irritable bowel syndrome predominant constipation Irritable bowel syndrome mixed