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Ataxia-telangiectasia complicated with Hodgkin's lymphoma:A case report

World Journal of Clinical Cases 2020年第11期8卷 2387-2391页

作者： Xiao-Ling Li Yi-Lin Wang Department of Pediatrics(III) The Linyi People’s HospitalLinyi 276000Shandong ProvinceChina

BACKGROUND Ataxia-telangiectasia(AT)is a rare,autosomal recessive,multisystem disorder.Because most clinicians have low awareness of the disease,only scarce reports of AT exist in the literature,especially of cases with lymphoma/leukemia.CASE SUMMARY A 7-year-old girl with a history of recurrent respiratory tract infections was referred to our department because of unstable walking for 5 years and enlarged neck nodes for 2-mo duration.Physical examination revealed scleral telangiectasia and cerebellar ataxia.Elevated alpha-fetoprotein,decreased serum immunoglobulin,and decreased T cell function were the major findings of laboratory examination.Histological analysis of cervical lymph node biopsy was suggestive of classical Hodgkin's lymphoma.genetic examination showed heterozygous nucleotide variation of c.6679C>T and heterozygous nucleotide variation of c.5773 delG in the atm gene;her parents were heterozygotes.The final diagnosis was AT with Hodgkin's lymphoma.CONCLUSION Clinicians should strengthen their understanding of AT diseases.gene diagnosis plays an important role in its diagnosis and treatment.

关键词： Ataxia-telangiectasia Hodgkin's lymphoma Child Case report atm gene

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Changes of the cell cycle regulators and cell cycle arrest in cervical cancer cells after cisplatin therapy

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Journal of Pharmaceutical Analysis 2009年第2期21卷 124-128页

作者： Ke-xiu Zhu,Ya-li Cao,Bin Li,Jia Wang,Xiao-bing Han Department of Obstetrics & Gynecology,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061,China. Department of Obstetrics and Gynecology First Affiliated Hospital Medical School of Xi'an Jiao-tong University Xi'an 710061 China

Objective To investigate the changes of the cell cycle regulators atm,Chk2 and p53 and cell cycle arrest in HeLa cells after cisplatin therapy. Methods The proliferation-inhibiting rates of HeLa cells induced by cisplatin of different concentrations were measured by MTT assays. The mRNA and protein expressions of atm,Chk2 and p53 of HeLa cells with and without cisplatin were detected by RT-PCR and Western blot,respectively. The cell cycle analysis was conducted by flow cytometric analysis. Results Cisplatin inhibited the proliferation of HeLa cells in a dose-and time-dependent manner. The mRNA and protein expressions of atm,Chk2 and p53 were increased in HeLa cells treated with cisplatin. The cell cycle was arrested in G2/M phase in HeLa cells treated with cisplatin. Conclusion Activation of atm,Chk2 and p53 might be critical in determining whether cells survive or undergo apoptosis. Targeting atm,Chk2 and p53 pathway might be a promising strategy for reversing chemoresistance to cisplatin in cervical cancer.

关键词： atm gene Chk2 gene p53 gene cell cycle cervical cancer cisplatin

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