Objective: To study the efficacy and mechanism of at-1 a new compound (an aqueous agent extracted from a Traditional Chinese herb with antiplatelet efficacy) on antitumor metastases in mice. Methods:at-1, a compound e...
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Objective: To study the efficacy and mechanism of at-1 a new compound (an aqueous agent extracted from a Traditional Chinese herb with antiplatelet efficacy) on antitumor metastases in mice. Methods:at-1, a compound extracted from a Traditional Chinese herb, was prepared by our lab. C57BL/6 female mice, which were transplanted H 22 liver cancer cells, received the agent. The tumor nodules, the pulmonary metastasis rate and tumor cell proliferation activity were tested. The tumor cells were exposed to different concentrations of at-1, and then the condition of the tumor proliferations were tested. Results: High and middle dosages of at-1 inhibited both the lymphatic and blood systemic tumor pulmonary metastases significantly, but had no effect on inhibition of the tumor cell proliferation in vitro. Conclusion:The major antitumor actions of at-1 may be on antitumor metastases, and the compounnd may be a new candidate for antitumor metastases agent. More study of the mechanism and action of at-1 on antitumor metastases and the actions are still being done deeply.
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