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Quality of reporting and adherence to the arrive guidelines 2.0 for preclinical degradable metal research in animal models of bone defect and fracture:a systematic review

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Regenerative Biomaterials 2022年第1期9卷 1167-1181页

作者： Fengxing Ding Kaiyan Hu Xia Liu Chen Liu Jinwei Yang Xinli Shi Bin Liu Mei Wu Zhe Wang Liyuan Feng Jiazhen Zhang Bin Ma School of Basic Medical Sciences Evidence-Based Medicine CenterLanzhou UniversityNo 199Donggang West RoadChengguan DistrictLanzhou 730000P.R.China Department of Pharmacology School of Basic Medical ScienceLanzhou UniversityLanzhou 730000P.R China Reproductive Medicine Center Gansu Provincial Maternity and Child-Care HospitalLanzhou 730000P.R.China Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081P.R China Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000P.R.China

In vivo testing is crucial for the evaluation of orthopedic implant efficacy and ***,the translation and reproducibility of preclinical animal experiments are not always satisfactory,and reporting quality is among the essential factors that ensure appropriate delivery of *** this study,we assessed the reporting quality of in vivo investigations that examined the use of degradable metal materials in fracture or bone defect *** employed scientific databases,such as PubMed,EMBASE,Web of Science,Cochrane Library,CNKI,WanFang,VIP and Sinomed to screen for in vivo investigations on fracture or bone defect repair using degradable metal materials,and extracted both epidemiological and main characteristics of eligible studies,and assessed their reporting quality using the arrive guidelines ***,263 publications were selected,including 275 animal *** overall coincidence rate of Essential 10(22 sub-items)and Recommended Set(16 sub-items)were 42.0%and 41.5%,*** on our analysis,the reporting quality of the published in vivo investigations examining fracture/bone defect repair with degradable metal materials was low,and there was a lack of transparent,accurate and comprehensive reporting on key elements of the experimental design and other elements that are meant to avoid bias.

关键词： arrive 2.0 animal research degradable metal bone defect fracture systematic review

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