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Anticancer Effect of Total annonaceous acetogenins on Hepatocarcinoma

Chinese Journal of Integrative Medicine 2015年第9期21卷 682-688页

作者：杨润梅李雯敏胡卫军黄文华朱春燕余竞光赵欣蔡大勇高南南 Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical College Henan Institute of Engineering

Objective： To confirm the anticancer effect of total annonaceous acetogenins （TAAs） abstracted from Annona squamosa Linn. on human hepatocarcinoma. Methods： The inhibitory effect of TAAs was demonstrated in H,,-bearing mice. The potency of TAAs was confirmed as its 50% inhibiting concentration （IC50） on Bel-7402 cell under Sulfur Rhodamine B staining. Both underlying mechanisms were explored as cellular apoptosis and cell cycle under flow cytometry. Mitochondrial and recipient apoptotic pathways were differentiated as mitochondrial membrane potential under flow cytometry and caspases activities under fluorescence analysis. Results： The inhibitory rate of TAAs in mice was 50.98% at 4 mg/kg dose. The IC50 of TAAs on Bel-7402 was 20.06 μg/mL （15.13-26.61 μg/mL）. Effective mechanisms of TAAs were confirmed as both of arresting cell cycle at G1 phase and inducing apoptosis dose- and time-dependently. Mitochondrial and recipient pathways involved in apoptotic actions of TAAs. Conclusion： TAAs is effective for hepatocarcinoma, via inhibiting proliferation and inducing apoptosis.

关键词： annonaceous acetogenins hepatocarcinoma proliferation apoptosis

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A Semi-Field Approach to Testing Botanical Insecticides. Effects of Natural and Analogues annonaceous acetogenins on <i>Spodoptera frugiperda</i>Smith (Lepidoptera: Noctuidae)

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Journal of Agricultural Chemistry and Environment 2021年第4期10卷 458-468页

作者： José Ruiz Hidalgo María Gabriela Murúa Adriana Neske Instituto de Química Orgánica Facultad de Bioquímica Química y Farmacia UNT Tucumán Argentina Instituto de Tecnologia Agroindustrial del Noroeste Argentino (ITANOA) Estación Experimental Agroindustrial Obispo Colombres (EEAOC)-CONICET Las TalitasTucumán Argentina Facultad de Ciencias Naturales e Instituto Miguel Lillo UNT Miguel Lillo San Miguel de Tucumán

annonaceous acetogenins enclose a large number of biological activities, among which the insecticidal stands out. Spodoptera frugiperda is a pest that affects corn crops among others and has a great capacity to develop resistance to traditional insecticides, which represents sufficient reasons for the search for new alternatives for their control. The objective of this study was to determine the appropriate concentration and screening new natural insecticides against second instar larvae of S. frugiperda, under glasshouse conditions on Zea mays L. Natural products such as annonaceous acetogenins and some acetylated and methoxy methylated ACG derivatives and the commercial product Lambda-cyhalotrin (LC) were evaluated. The percent mortalities of S. frugiperda larvae in glasshouse conditions were recorded after 24, 48 and 72 h of treatment application. The results showed that the acetogenins tested were significantly (P 5) (100 μg/mL) + squamocin (6) (100 μg/mL) + LC (50 μg/mL) that proved the most effective and gave (100%), while rolliniastatin-2 (5) at 100 μg/mL alone, gave lowest percent mortality (65%), followed by squamocin (6) at 100 μg/mL (55%) and LC at 50 μg/mL (30%). The acetylated and methoxy methylated ACGs derivatives caused very low mortality (25% - 35%). It is recommended the mixture as a management option of S. frugiperda as a component of integrated pest management. The results allow us to infer that the addition of natural ACGs synergizes the insecticidal activity of the commercial product. Finding a new ecological alternative for insect control.

关键词： annonaceous acetogenins Biocides Spodoptera frugiperda

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Donhexocin,a New Non-tetrahydrofuran Acetogenin from Goniothalamus Donnaiensis

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Chinese Chemical Letters 1997年第3期8卷 233-234页

作者： Jiang, Z Yu, DQ CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

A novel bioactive annonaceous acetogenin, donhexocin (1), has been isolated from the roots of Goniothalamus donnaiensis (Annonaceae). 1 is a new acetogenin lacking THF rings but bearing six hydroxyls including two vic-diol systems in the aliphatic chain. Its structure and stereochemistry has been elucidated by spectoscopic analysis and derivatization.

关键词： annonaceous acetogenins

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Absolute Configurations of Tonkinin A and B: Two New acetogenins from Uvaria Tonkinensis

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Chinese Chemical Letters 1997年第9期8卷 789-790页

作者： Chen, Y Yu, DQ CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

The absolute stereochemistries of annonaceous acetogenins, tonkinin A and B, have been established by the use of the convenient conversion to their formaldehyde acetal derivatives and the subsequent application of the... 详细信息

关键词： annonaceous acetogenins DERIVATIVES

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