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Salicylic acid sensitizes cervical cancer cells to radiotherapy by activating ampk/tsc2/mtor pathway

Radiation Medicine and Protection 2022年第1期3卷 9-15页

作者： Shun Lu Wenjing Ye Jie Zhou Guangming Yi Jianming Huang Siyao Deng Minglun Li Yimin Li Yanqiong Song Jiayu Zhang Lichun Wei Guiquan Zhu Jinyi Lang Department of Radiation Oncology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610042China Department of Radiological Protection Radiation Oncology Key Laboratory of Sichuan ProvinceChengdu 610042China School of Medicine University of Electronic Science and Technology of ChinaChengdu 610042China The Third Hospital of Mianyang Sichuan Mental Health CenterMianyangSichuan 621054China Department of Radiation Oncology University HospitalLMUMunichGermany Department of Radiation Oncology Xijing HospitalAir Force Medical UniversityXi'anShaanxi 610599China State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesDepartment of Head and Neck OncologyWest China Hospital of StomatologySichuan UniversityChengdu 610041China

Objective:To investigate the radio-sensitizing effect of salicylic acid(SA)on human cervical cancer cells and its potential molecular ***:Cervical cancer cells were treated with SA and ionizing *** expression ofγ-H2AX was evaluated by immunofluorescence(IF)*** cycle and apoptosis were analyzed by flow *** blot was performed to detect the protein level of ampk/tsc2/mtor ***:SA inhibited basal proliferation of cervical cancer cells in a dose and time dependent *** addition,SA increased radiation-induced DNA damage,promoted apoptosis,triggered a redistribution of cell cycle from G2-M phase to G1-S phase of cervical cancer cells,and hence increased cell sensitivity to ***,SA treatment elevated the expression levels of p-ampkα(t=3.996,Ptsc2(t=5.308,Pmtor(t=10.160,Pampk/tsc2/mtor signaling pathway,and might serve as a promising therapeutic strategy to improve the efficacy of radiotherapy for cervical cancer.

关键词： Cervical cancer Salicylic acid Radiosensitivity ampk/tsc2/mtor pathway

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