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The role of 5′-adenosine monophosphate-activated protein kinase(ampk)in skeletal muscle atrophy

BIOCELL 2023年第2期47卷 269-281页

作者： KAI DANG HAFIZ MUHAMMAD UMER FAROOQ YUAN GAO XIAONI DENG AIRONG QIAN Laboratory for Bone Metabolism Xi’an Key Laboratory of Special Medicine and Health EngineeringKey Laboratory for Space Biosciences and BiotechnologyResearch Center for Special Medicine and Health Systems EngineeringNPU-UAB Joint Laboratory for Bone MetabolismSchool of Life SciencesNorthwestern Polytechnical UniversityXi’an710072China

As a key coordinator of metabolism,AMP-activated protein kinase(ampk)is vitally involved in skeletal muscle *** exerts its cellular effects through its function as a serine/threonine protein kinase by regulating many downstream targets and plays important roles in the development and growth of skeletal *** is activated by phosphorylation and exerts its function as a kinase in many processes,including synthesis and degradation of proteins,mitochondrial biogenesis,glucose uptake,and fatty acid and cholesterol *** muscle atrophy is a result of various diseases or disorders and is characterized by a decrease in muscle *** pathogenesis and therapeutic strategies of skeletal muscle atrophy are still under *** this review,we discuss the role of ampk in skeletal muscle metabolism and *** also discuss targeting ampk for skeletal muscle treatment,including exercise,ampk activators including 5-amino-4-imidazolecarboxamide ribonucleoside and metformin,and low-level *** studies show the important roles of ampk in regulating muscle metabolism and function;thus,the treatment of skeletal muscle atrophy needs to take into account the roles of ampk.

关键词： ampk,autophagy Protein degradation,Protein synthesis,Skeletal muscle atrophy,Ubiquitin

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