Objective Fusion protein is a subunit of the human respiratory syncytial virus(HRSV)and a potential vaccine ***,a study on the genetic characteristics of F protein was considered important for further investigations i...
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Objective Fusion protein is a subunit of the human respiratory syncytial virus(HRSV)and a potential vaccine ***,a study on the genetic characteristics of F protein was considered important for further investigations in this *** aim of this study was to determine the prevalence and genetic diversity of the F gene of HRSV infections in hospitalized pediatric patients in Beijing with acute lower respiratory tract infections and to compare the circulating genotypes that are currently found *** HRSV particles were amplified by RT-PCR and the PCR products were purified for *** analysis was carried out by Bioedit and MEGA 3.0 biological software *** Seventy-six samples(23.1%)were positive for *** percentage of cases in patients younger than 1year was 84.21%.Among the six Beijing isolates,four belonged to subgroup A,whose respective F genes shared97.0%-97.4%nucleotide sequence identity and 92.1%-93.0%amino acid sequence *** other two isolates belonged to subgroup ***,97.3%and 98.2%sequence identity were found at nucleotide and amino acid levels,*** Phylogenetic analysis of nucleotide sequences revealed that those four isolates within subgroup A were monophyletic and closely related to each other,but those two within subgroup B distributed in two distinct *** A and B strains co-circulated,indicating that two different transmission chains occurred in Beijing from 2003-2004.
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