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Spontaneously Immortalized B lymphocytes from patients with aids-related lymphoma are diagnostic and prognostic biomarkers

Spontaneously Immortalized B lymphocytes from patients with ...

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第十三届全国免疫学学术大会

作者： Ke Zhuang Yongxi Zhang Zhigao Xu Xiqiu Xu Fengzhen Meng Xiaoying Qi Yong Xiong Deying Guo Xien Gui ABSL-III Laboratory at the Center for Animal Experiment Wuhan University Department of Infectious Diseases Zhongnan Hospital of Wuhan University Department of Pathology Zhongnan Hospital of Wuhan University Basic Medical College of Wuhan University School of Basic Medicine (Shenzhen) Sun Yat-sen University

A valuable marker derived from patients with aids-related lymphoma(ARL) is needed for auxiliary diagnosis and prognosis. In this study, we generated spontaneously immortalized B lymphocyte cell(SIBC) lines by culturing peripheral blood mononuclear cells derived from 14 ARL patients and evaluated their clinical significance for auxiliary diagnosis and prognosis. From 10 pre-chemotherapy patients, a total of 5 new cell lines grew spontaneously without Cys A and EBV from five patients who showed a relapse and refractory ARL afterwards, presenting mainly memory B-cell markers(CD3-CD20+CD27+). However, SIBC lines could not be generated from healthy individuals(n=24). Among 8 post-chemotherapy patients, only 2 SIBC lines were generated from two ARL patients who had severe symptoms with multiple organs involved and died soon after chemotherapy;the other 6 ARL patients without SIBC lines survived for 1-5 years. Moreover, All SIBC lines exhibited monoclonal Ig gene rearrangement and presented a high level of cellular EBV DNA. These findings suggest that the SIBC lines are representative of the malignant B-lymphocytes circulating in ARL patients and might originate from the lymphoma tissue of ARL patients. These data provide evidence of a potentially valuable auxiliary diagnostic and prognostic biomarker for patients with ARL.

关键词： Spontaneous immortalized B cell aids-related lymphoma ARL

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