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Chinese herbal medicine and COVID-19: quality evaluation of clinical guidelines and expert consensus and analysis of key recommendations

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Acupuncture and Herbal Medicine 2022年第3期2卷 152-161页

作者： Qingyong Zheng Ya Gao Lu Xiong Hengyi Huang Junfen Li Guoyuan OuYang WulayinSaimire Jingjing Yang Yu Zhang Xiaopeng Wang Xiaofeng Luo School of Public Health Lanzhou UniversityLanzhouChina School of Nursing Evidence-based Nursing CenterLanzhou UniversityLanzhouChina Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonOntarioCanada The First Clinical School of Medicine Lanzhou UniversityLanzhouChina The Second Clinical Medical College of Lanzhou University LanzhouChina

Objective:To systematically review the clinical practice guidelines(CPGs)for the treatment of patients with coronavirus disease 2019(COVID-19)using Chinese herbal medicine(CHM),assess the methodological quality as well as clinical credibility and implementability of specific recommendations,and summarize key ***:As of April 2022,we conducted a comprehensive search on major electronic databases,guideline websites,academic society websites,and government websites to assess the methodological quality and clinical applicability of the included CPGs using the Appraisal of Guidelines for Research and Evaluation(agree)II tool and Evaluation-Recommendations EXcellence(agree-rex)instructions,***:The search yielded 61 CPGs,which were mostly published in 2020;moreover,98.4%of the CPGs were published in *** five CPGs achieved a high-quality agree II rating;further,six CPGs could be directly recommended,with most of the CPGs still showing much room for *** had a low overall score in the agree-rex evaluation,with the domains of clinical applicability,values and preferences,and implementability being standardized in 21.80%±12.56%,16.00%±11.81%,and 31.33%±14.55%of the CPGs,*** high-quality CPGs mentioned 56 Chinese herbal *** of the recommendations had moderate or strong evidence level in the GRADE *** most frequently recommended herbal medicines were Lianhua Qingwen granule/capsule and Jinhua Qinggan granule;however,the strength of recommendation for each prescription varied across CPGs and ***:The overall quality of current CPGs for COVID-19 for CHM still needs to be improved;moreover,the strength of the evidence remains to be standardized across CPGs.

关键词： agree II agree-rex Chinese herbal formulations COVID-19 Guideline Quality evaluation

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