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CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

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Health 2017年第11期9卷 1467-1474页

作者： Juan Raymundo Velazquez Gabriela Soid-Raggi Luis Manuel Teran Gandhi Fernando Romero-Pavon Fernando Ramírez-Jimenez Instituto Nacional de Enfermedades Respiratorias (INER) Mexico City Mexico Facultad de Ciencias Universidad Nacional Autónoma de México (UNAM) Mexico City Mexico

Aspirin-exacerbated respiratory disease (aerd) is an asthma phenotype characterized by nasal polyps, chronic hypertrophic eosinophilic sinusitis, asthma, and sensitivity to aspirin. Unawareness of this disease by patients and their physicians may have serious consequences because of the risk of near-fatal asthma. Its confirmative diagnosis can be established only by provocative aspirin challenge, which represents a potential risk for patient health. Purpose: Because CCL4 plays an important role in several pulmonary conditions, we tested its immunoreactivity in nasal lavages and sera from control subjects, and from aspirin-sensitive and non-aspirin-sensitive patients. Method: Immunoreactivity of CCL4 was measured in serum and nasal lavages from 30 healthy controls (HC), 23 patients with aerd, and 20 patients with aspirin-tolerant asthma (ATA). Additionally, a serum biobank contained sera from 90 HC, 83 patients with aerd, and 69 patients with ATA was employed. Results: The serum immunoreactivity of CCL4 could distinguish both types of asthma phenotypes. Conclusion: CCL4 may play an unexpected role in thephysiopathology of aerd.

关键词： aerd CCL4 Asthma

Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 220-229页

作者： Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher Department of Otolaryngology-Heat and Neck Surgery University of South Florida Morsani College of Medicine12901 Bruce B.Downs Blvd.MDC 73TampaFL 33612USA University of South Florida Morsani College of Medicine 12901 Bruce B.Downs BlvdTampaFL33612USA

Objective:To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease(aerd)following endoscopic sinus surgery and subsequent aspirin ***:Electronic searches of OVID MEDLINE(1948 to September 10,2019),EMBASE(1980 to September 10,2019),and PubMed were performed on September 10,2019.A systematic review of the literature was performed using the 2009 PRISMA *** with both preoperative and postoperative data for patients with aerd who underwent sinus surgery and aspirin desensitization were considered appropriate for *** were written in English and included patients aged 18 years or ***:Six studies met inclusion criteria for this systematic *** primary outcome measure was change in symptom profile measured by patient-reported quality of life *** results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery,with sustained improvement following aspirin *** surgery rates were significantly lower in patients maintained on aspirin ***:This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome *** adjunctive use of aspirin desensitization allows for long-term stability in symptom *** of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is inter-rupted.

关键词： aerd Aspirin-exacerbated respiratory disease Aspirin desensitization Endoscopic sinus surgery Nasal polyps Chronic sinusitis with nasal polyps

The impact of endoscopic sinus surgery and aspirin desensitization on psychological burden in aspirin-exacerbated respiratory disease

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 214-219页

作者： Tran Locke Auddie Sweis Theodore Lin Brian Sweis Patrick Gleeson Michael Kohanski Nithin Adappa James Palmer John Bosso Deportment of Otolarynsology Baylor College of MedicineHoustonTXUSA Division of Otolaryngology NorthShore University Health SystemEvanstonILUSA Lewis Kotz School of Medicine Temple UniversityPhiladelphiaPAUSA Department of Neuroscience University of MinnesotaMinneapolisMNUSA Department of Allersy Et Immunolosy University of PennsylvaniaPhiladelphiaPAUSA Deportment of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPAUSA

Background:Aspirin-exacerbated respiratory disease(aerd)is an aggressive inflammatory disorder of the upper and lower respiratory ***,leukotriene modifiers,endoscopic sinus surgery(ESS),aspirin(ASA)desensitization,and biological immu-nomodulators are currently used to treat the ***:The objective of this study was to determine the psychosocial impact of ESS and ASA desensitization on aerd ***:All aerd patients who underwent complete ESS were divided into two cohorts based on ASA desensitization *** psychosocial metrics of the SNOT-22 were collected and analyzed at the following time points:pre-operative,1-month,3-month,6-month,and 12-month after ***:One hundred and eighty-four aerd patients underwent ESS from November 2009 to November *** this group,130 patients underwent ASA desensitization(AD cohort)and 54 patients remained non-desensitized(ND cohort).AD patients showed a significantly greater reduction in total SNOT-22 scores over the study period compared to ND patients(p=0.0446).Analysis of SNOT-22 psychosocial metrics showed a significantly greater improvement in patient productivity in the AD cohort when compared to the ND cohort(p=0.0214).Further,a sub-group analysis accounting for subject attrition showed a significantly greater improvement in both productivity and concentration in AD patients when compared to the ND cohort(productivity:p=0.0068;concentration:p=0.0428).Conclusions:ESS followed by ASA desensitization decreases the overall psychosocial burden in aerd patients with a significant improvement in perceived productivity and *** has significant implications given the psychosocial impact of chronic diseases.

关键词： Psychosocial domain aerd Aspirin desensitization Sinus surgery

Olfactory outcomes in the management of aspirin exacerbated respiratory disease related chronic rhinosinusitis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 207-213页

作者： Daniel B.Spielman Jonathan Overdevest David A.Gudis Departm ent of Otolaryngology-Head and Neck Surgery Columbia University Medical CenterNew YorkNY10032USA

Patients with aspirin exacerbated respiratory disease(aerd)experience a severe and recalcitrant form of chronic rhinosinusitis with nasal polyposis(CRSwNP)and asthma,which are exacerbated by aspirin/NSAID *** compared with aspirin-tolerant CRSwNP,patients with aerd experience more severe olfactory dysfunction,which is one of the key contributors to the observed decrease in quality of life(QOL)in this *** objective of this paper is to review the published olfactory outcomes observed with various treatment modalities.

关键词： Aspirin exacerbated respiratory disease aerd Samter’s Triad Olfaction hyposmia Endoscopic sinus surgery Aspirin desensitization NSAID

Biologic therapies versus surgical management for aspirin-exacerbated respiratory disease:A review of preliminary data,efficacy,and cost

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 230-234页

作者： Alan D.Workman Benjamin S.Bleier Department of Otolarynsology Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonM Af USA

Aspirin-exacerbated respiratory disease(aerd)patients with CRSwNP suffer from reduced quality of life,reduced economic productivity,and higher risk of depression and sleep *** patients often require frequent medical and surgical therapy,including functional endoscopic sinus surgery for recalcitrant *** this severity,anti-type 2 biologic treatments are being investigated for use in this subgroup of patients with CRSwNP,including Omalizumab and *** data suggests that SNOT-22 related quality of life improvements following treatment with biologies are comparable to the current standard of care in the short term,but there is a lack of long-term data and standardized regimen that makes direct comparison *** therapies additionally require continuous use to avoid recurrence,and currently cost many times more than existing medical or surgical therapies.

关键词： CRSwNP aerd Biologics Omalizumab Dupilumab

CEPC顶点探测器原型芯片MIC4的数字读出设计与实现

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CEPC顶点探测器原型芯片MIC4的数字读出设计与实现

作者：游必辉华中师范大学

学位级别：硕士

自希格斯粒子被发现以来,精确测量该粒子的特性和探索超越标准模型的新物理逐渐成为高能物理领域的研究热点。为精确测量希格斯粒子的特性,我国科学家提出了环形正负电子对撞机(Circular Electron-Positron Collider,CEPC)计划。单片有... 详细信息

自希格斯粒子被发现以来,精确测量该粒子的特性和探索超越标准模型的新物理逐渐成为高能物理领域的研究热点。为精确测量希格斯粒子的特性,我国科学家提出了环形正负电子对撞机(Circular Electron-Positron Collider,CEPC)计划。单片有源像素传感器(Monolithic Active Pixel Sensors,MAPS)是CEPC顶点探测器的核心部件,用于精确测量重味粒子与轻子的位置和时间信息,需具备高位置分辨率、高读出速率、低功耗以及抗辐照等特性。具备该特性且能够将所有像素位置信息独立的、不丢失的读出到芯片外同时面积较小的数字读出电路设计是MAPS设计的关键之一。本文主要研究工作是将经典的Token结构与aerd(Address Encode and Reset Decode)结构相结合提出了一种数据驱动型读出架构,并在Tower Jazz 180nm CIS工艺下设计流片,实现了CEPC顶点探测器中MAPS的数字读出。其具体研究内容和创新点如下:1.把Token与aerd结构相结合,提出了全新的数据驱动型读出架构:在8行8列共64个像素单元组成的超级像素中采用Token结构,超级像素外使用aerd结构。超级像素内用Token结构实现非零数据压缩、缩小面积,超级像素外用aerd实现16行8列超级像素阵列的快速读出与低功耗。结果表明:采用Token技术后超级像素面积可缩小至25μm×25μm,从而提高了位置分辨率。2.设计了无片上存储器且能实时输出数据的数字读出电路:在MAPS芯片内使用一个23bit× 16的小容量FIFO将像素阵列读出的23bit数据转换成8bit数据,再将该8bit数据进行组帧后输出,从而实现了MAPS的8位并行实时读出和减小芯片面积,每帧数据仅需0.425μs,当击中率较低时,数据帧中包含时间信息。3.数字读出电路的物理设计与测试:根据顶点探测器设计指标,对数字读出电路进行时序约束并使用Design Compiler生成门级网表,之后通过Encounter完成该网表的版图设计。通过对该MAPS芯片的数字读出进行测试,观察到了良好的成像效果,从而验证了数字读出设计的正确性。

关键词： MAPS aerd 数字读出时序约束物理设计