检索结果-南通市图书馆

采用响应曲面法对Capto adhere填料进行工艺优化

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海医药 2020年第9期41卷 67-71,79页

作者：吴光昊何慧丹徐翀颿顾鑫刘彦君上海交联药物研发有限公司上海201203 上海医药集团股份有限公司中央研究院上海201203

为对复合阴离子Capto adhere填料进行纯化工艺优化,在前期单因素试验基础上,CHO细胞表达的IgG1型单克隆抗体细胞培养上清液经亲和层析纯化后,采用中心复合表面设计(CCF)法优化Capto adhere填料纯化工艺。以收率、纯度、HCP清除率为响应... 详细信息

为对复合阴离子Capto adhere填料进行纯化工艺优化,在前期单因素试验基础上,CHO细胞表达的IgG1型单克隆抗体细胞培养上清液经亲和层析纯化后,采用中心复合表面设计(CCF)法优化Capto adhere填料纯化工艺。以收率、纯度、HCP清除率为响应变量,考察pH、电导率、载量3个关键因素对纯化工艺的影响,拟合模型并验证。优化后最佳工艺条件为:pH 7.0,电导率16.4 ms/cm,载量300 mg/ml,在此条件下,收率、纯度和HCP清除率分别可达(90.77±0.77)%、(99.55±0.05)%和(88.93±2.14)%。与预测结果偏差均adhere填料工艺优化是有效可行的。

关键词：中心复合设计 Capto adhere 抗体纯化

美国心力衰竭住院患者的特点及预后:急性失代偿性心衰国家登记(adhere)研究的前10万病例中的原理、设计和初步观察

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 20-20页

作者： Adams Jr. K.F. Fonarow G.C. Emerman C.L. 任付先 UNC Heart Failure Program 730 Airport Road Chapel Hill NC 27514- 5738 United States

Background: The adhere is designed to study characteristics, management, and outcomes in a broad sample of patients hospitalized with acute decompensated heart failure. Heart failure is a leading cause of hospitalization for adults older than 65 years in the United States. Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single- center studies. Methods: Participating hospitals identify patients with a primary or secondary discharge diagnosis of heart failure. Medical history, management, treatments, and health outcomes data are collected through review of medical records and entered into a database via secure web browser technology. Results: As of January 2004, data on 107 362 patients have been received from 282 participating hospitals. Of enrollees with available analyzable data(N=105 388 from 274 hospitals), the mean age was 72.4(± 14.0), and 52% were women. The most common comorbid conditions were hypertension(73% ), coronary artery disease(57% ), and diabetes(44% ). Evidence of mild or no impairment of systolic function was found in 46% of patients. Inhospital mortality was 4.0% and the median hospital length of stay was 4.3 days. Conclusions: The adhere demonstrates both the feasibility and significant implications of gathering representative data on large numbers of patients hospitalized with heart failure. Initial data provided important insights into the clinical characteristics and patterns of care of these patients. Ongoing registry work will provide the framework for improved treatment strategies for patients hospitalized with decompensated heart failure.

关键词： adhere 失代偿性出院诊断安全网络收缩功能患者临床特征病历记录伴发疾病单中心注册工作

Optimized Bio-inspired Micro-pillar Dry Adhesive and Its Application for an Unmanned Aerial Vehicle Adhering on and Detaching from a Ceiling

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2020年第1期17卷 45-54页

作者： Qingsong He Xianrui Xu Zhiwei Yu Kai Huo Zhaoyang Wang Nuo Chen Xuean Sun Gui Yin Peile Du Yang Li Zhendong Dai Institute of Bio-inspired Structure and Surface Engineering Jiangsu Provincial Key Laboratory of Bionic Functional MaterialsCollege of Mechanical and Electrical EngineeringNanjing University of Aeronautics&AstronauticsNanjing 210016China College of Astronautics Nanjing University of Aeronautics&AstronauticsNanjing 210016China China Ship Development and Design Center Shanghai Branch Shanghai 201108China

Various bio-inspired dry adhesive materials have been *** this work,lithography and silicon deep etching method were used to fabricate bio-inspired micro-pillar dry adhesive materials of which the parameters,such as side length,Height to Side length Aspect Ratio(HSAR),and inter-pillar Distance to Side length Aspect Ratio(DSAR)were comprehensively studied to obtain a dry adhesive with high *** orthogonal array method was designed and a series of fabrication experiments were conducted to identify optimum parameters,which resulted in a high normal adhesion of 2.98 N·cm^-2 and a shear adhesion of 9.59 N·cm^-*** adhesion and desorption device was further designed on basis of the optimum dry adhesive,which enables an Unmanned Aerial Vehicle(UAV)to successfully adhere on and detach from a *** would allow an UAV to stay aloft for prolonged time,which could be invaluable to many applications,such as energy conservation and aerial detection.

关键词： bio-inspired dry adhesive orthogonal array method UAV adhere ceiling

DoE实验设计开发23价肺炎多糖疫苗层析纯化平台工艺

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国新药杂志 2016年第10期25卷 1121-1126页

作者：季宇 Mattias Ahnfelt 贾国栋通用电气(中国)研究开发中心有限公司上海201203

目的:应用Do E实验设计,建立一种新型23价肺炎多糖疫苗层析纯化工艺平台。方法:将23F型肺炎粗糖样品作为开发样品溶解并预处理后,采用Do E设计开发基于Capto adhere的纯化工艺。色谱纯化过程采用流穿模式,通过Do E分析获得工艺参数,在... 详细信息

目的:应用Do E实验设计,建立一种新型23价肺炎多糖疫苗层析纯化工艺平台。方法:将23F型肺炎粗糖样品作为开发样品溶解并预处理后,采用Do E设计开发基于Capto adhere的纯化工艺。色谱纯化过程采用流穿模式,通过Do E分析获得工艺参数,在该条件下将多糖和其他杂质分离,并作为纯化平台应用于其他血清型多糖。根据《欧洲药典》7.0的方法和标准,对样品的各项指标进行检测。结果:23F型多糖在柱上流穿,多糖与蛋白和核酸完全分离,应用此工艺平台至其他血清型多糖上,纯化的多糖样品各项指标也均符合《欧洲药典》7.0的标准。结论:通过Do E实验设计快速建立了一种新型肺炎多糖疫苗层析纯化工艺平台,缩短生产时间,提高产品质量,代替传统的有毒苯酚抽提工艺,可用于23价肺炎多糖纯化和23价肺炎多糖疫苗生产。

关键词：肺炎多糖层析 Capto adhere 疫苗 DoE

China's Peaceful Development Road: Cultural Foundation, Strategic Orientation and Practical Significance

在线全文

学校读者我要写书评

暂无评论

Peace 2015年第4期 44-62页

作者： Xiao Xi Jilin University

Unswervingly pursuing the peaceful development road is the strategic choice made by the Government and people of China based on a development trend of the times and the national fundamental interests. As the traditional cultural origin of China's peaceful development road, "harmony" is one constant principle permeated through China's culture, and is true life for China humanistic spirit. "valuable harmony", "harmony without blind following", "harmony between heaven and man" are three important aspects of "harmony"-- thinking ideological connotation of China's culture. The practice has proved that as the national long-term development strategy, the peaceful development road is the development road adapted to China's conditions and era features, and has made outstanding contributions to peace and development of China and the world at large.

关键词： harmony cooperation peace Orientation adhere thinking contributions spirit mutual interests

The Status Quo and Prospect of Chinese-funded Enterprises Technology Transfer to Africa

在线全文

学校读者我要写书评

暂无评论

Peace 2015年第4期 24-34,23页

作者： Yang Guang Li Xinfeng Chen Mo Institute of West Asia-African Studies Chinese Academy of Social Sciences CASS

Weak technical foundation is an important bottleneck to restrict economic growth of African countries. To promote the technological progress of Africa, the Chinese African strategy always encourages and supports Chinese-funded enterprises to transfer technology to Africa, but it is worth nothing that the critique by some African scholars and local communities on technology transfer to Africa by the Chinese-funded enterprises is spreading. In fact, in order to implement the "localization" strategy, develop African market or honor cooperation agreement on additional technical transfer, Chinese-funded enterprises always adhere to actively carrying out technology transfer to Africa, and have made certain achievements in improving the host countries' technical environment, increasing labor income and others. In order to cope with the challenges and dispel the crisis of public opinion, China should uphold the concept of "teaching how to fish" and push forward the continuous upgrading and optimization of technology transfer to Africa all-dimensionally.

关键词： Africa funded cooperation adhere technological honor carrying trained companies restrict

Good-Neighbor Relations is the Best Guarantee for National Security

在线全文

学校读者我要写书评

暂无评论

Peace 2016年第3期 26-,15页

作者： Liu Si Daily Telegraph

In the face of doubts and objections for introduction of the THAAD system into in South Korea,ROK President Park Geun-hye just after the end of the summer vacation stressed at the ROK state meeting that the deployment of the THAAD system is to protect the South Korean people from North Korea’s nuclear and missile threats,which is related to national and public safety,thus,cannot be changed.

关键词： Neighbor missile deployment Korea protect stressed resolve neighbor turmoil adhere

Briefing of the 13th Five Year Development Plan of the National Natural Science Fund

在线全文

学校读者我要写书评

暂无评论

Science Foundation in China 2016年第3期24卷 1-4页

(June 14,2016)National Natural Science Foundation of China The 18th National Congress of the Communist Party of China pledged to implement the innovation-driven development strategy and made overall planning for the comprehensive innovation with scientific and technological innovation as the *** 5th Plenary Session of the 18th CPC Central Committee depicted the grand blueprint for China’s development in the next five years and proposed to firmly establish

关键词： NSFC technological firmly funding disciplines Communist adhere innovative dissemination encourage

ALLERGY AND IMMUNOLOGY

在线全文

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 1995年第3期12卷 140-142页