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A potential impact of a disintegrin and metalloproteinase domain-like protein decysin-1(ADAMDEC1)on clear cell renal cell carcinoma propagation

引用

BIOCELL 2022年第8期46卷 1893-1901页

作者： MAGDALENA RUDZIŃSKA-RADECKA Foundation of Research and Science Development Warsaw01-793Poland

Clear cell renal cell carcinoma(KIRC)is the most common and aggressivemalignancy subtype of renal neoplasm that arises from proximal convoluted *** is characterized by poor clinical outcomes and high mortality of patients due to the lack of specific biomarkers for varying stages of the disease and no effective *** are associated with the development of several malignant tumors in humans by their ability to degrade extracellular matrices,facilitating ***,differentially expressed genes in KIRC cases compared to healthy kidneys were screened out from the Gene Expression Profiling Interactive Analysis(GEPIA)*** data was applied to determine the most elevated protease in KIRC and as a result,a disintegrin and metalloproteinase domain-like protein decysin-1(ADAMDEC1)was *** expression pattern was exclusive for KIRC and not observed for papillary and chromophobe renal cell carcinomas,in which ADAMDEC1 was at the same level in tumors and non-cancer ***,the ADAMDEC1 significant increase was detected in the fourteen other human malignancies compared to healthy samples,which suggested its strong involvement in cancer ***,GEPIA and Pathology Atlas correlated ADAMDEC1 high expression with more advanced tumor grade and shorter survival of KIRC *** Functional Genomics Explorer presented that ADAMDEC1 could be hypermethylated in some tumor cases and one somatic mutation in the gene sequence was ***,a Search Tool for the Retrieval of Interacting Genes/proteins;STRING base was utilized to predict the interactions of ADAMDEC1 with other molecules and construct the signaling *** summary,ADAMDEC1 showed the tremendous potential to be the predictive marker for the KIRC and its ***,this review with data analysis can be a good base for further in vitro and in vivo research that experimentally can confirm the ADAMDEC1 as prognostic biomarkers and therapeuti

关键词： a disintegrin and metalloproteinase domain-like protein decysin-1 ADAMDEC1 Clear cell renal cell carcinoma Patient specimens Databases

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