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High levels of interleukin-6 and 8-iso-prostaglandin in the exhaled breath condensate and serum of patients with chronic obstructive pulmonary disease related pulmonary hypertension

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Chinese Medical Journal 2014年第9期127卷 1608-1612页

作者： He Haiyan Tao Yijiang Chen Xiaoxiao Qiu Haiyan Zhu Jie Zhang Jianhui Ma Hang Department of Respiratory Diseases First People's Hospital of Nantong Nantong Jiangsu 226001 China

Background Pulmonary hypertension （PH） is a common complication of chronic obstructive pulmonary disease （COPD）. Although alveolar hypoxia is considered as a main cause of PH in COPD, structural and functional changes of pulmonary circulation are apparent at the initial stage of COPD. We hypothesized that an inflammatory response and oxidative stress might contribute to the formation of PH in COPD. Methods We measured the levels of interleukin-6 （IL-6） and 8-iso-prostaglandin （8-iso-PSG） in exhaled breath condensate （EBC） and serum in 40 patients with COPD only or in 45 patients with COPD combined with PH. Pulmonary arterial systolic pressure （PASP） was assessed by Doppler echocardiography and defined as PH when the value of systolic pressure was greater than 40 mmHg. Results Compared with the COPD only group, the level of IL-6 in EBC was significantly increased in all 45 patients with COPD combined with PH （（8.27±2.14） ng/L vs. （4.95±1.19） ng/L, P 〈0.01）. The level of IL-6 in serum was also elevated in patients with COPD combined with PH compared with the COPD only group （（72.8±21.6） ng/L vs. （43.58±13.38） ng/L, P 〈0.01 ）. Similarly, we also observed a significant increase in the level of 8-iso-PSG in both EBC and serum in the COPD with PH group, compared with the COPD only group （EBC：（9.00±2.49） ng/L vs. （5.96±2.31） ng/L, P 〈0.01 and serum：（41.87±9.75） ng/L vs. （27.79±11.09） ng/L, P 〈0.01）. Additionally, the value of PASP in the PH group was confirmed to be positively correlated with the increase in the levels of IL-6 and 8-iso-PSG in both EBC and serum （r=0.477-0.589, P 〈0.05）. Conclusion The increase in the levels of IL-6 and 8-iso-PSG in EBC and serum correlates with the pathogenesis of PH in COPD.

关键词： chronic obstructive pulmonary disease pulmonary hypertension interleukin-6 8-iso-prostaglandin exhaled breath condensate

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8-异前列腺素F2а与早期糖尿病肾病关系的临床研究

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中国实用医药 2010年第8期5卷 6-8页

作者：裴薇逄力男柳林吴琰张金华潍坊医学院 261042 潍坊市人民医院内分泌科

目的探讨血浆8-异前列腺素F2а(8-iso-prostaglandin F2α,8-isoPGF2α)水平与早期糖尿病肾病的关系及临床意义。方法选择2型糖尿病患者63例,分为单纯糖尿病组(22例)和早期糖尿病肾病组(41例);以同期健康查体者31例作为正常对照组,用EL... 详细信息

目的探讨血浆8-异前列腺素F2а(8-iso-prostaglandin F2α,8-isoPGF2α)水平与早期糖尿病肾病的关系及临床意义。方法选择2型糖尿病患者63例,分为单纯糖尿病组(22例)和早期糖尿病肾病组(41例);以同期健康查体者31例作为正常对照组,用ELISA法检测3组血浆8-isoPGF2а水平,并进行统计学分析。结果单纯糖尿病组、早期糖尿病肾病组和对照组患者血浆8-isoPGF2а水平分别为(394.5±104.1)pg/ml、(562.7±211.8)pg/ml和(292.7±66.7)pg/ml,组间比较差异有统计学意义(F=13.907,P8-isoPGF2а水平显著升高,差异有统计学意义(P8-isoPGF2а水平明显升高,差异有统计学意义(P=0.001)。血浆8-isoPGF2а水平与HbA1c呈显著正相关(r=0.349,P=0.012)。结论2型糖尿病肾病早期氧化应激水平明显增加,检测血浆8-isoPGF2а水平对于预测早期糖尿病肾病可能具有一定临床意义。

关键词： 2型糖尿病糖尿病肾病 8-iso-prostaglandin F2а 氧化应激

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Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men: An electron spin resonance investigation

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Advances in Bioscience and Biotechnology 2012年第7期3卷 1020-1027页

作者： Kazushi Tsuda Cardiovascular and Metabolic Research Center Kansai University of Health Sciences Osaka Japan

There is evidence showing that increased levels of oxidative stress and C-reactive protein (CRP) might be associated with obesity, hypertension, atherosclerosis and other cardiovascular diseases. This study was undertaken to investigate possible relationships among plasma 8-iso-prostaglandin F2α (8-iso-PG F2α: an index of oxidative stress), high-sensitivity (hs)-CRP and membrane fluidity (a reciprocal value of microviscosity) in hypertensive and normotensive men using an electron spin resonance (ESR)-method. The order parameter (S) for the spin-label agents (5-nitroxide stearate) of red blood cell (RBC) membranes in the ESR spectra was significantly higher in hypertensive men than in normotensive men, indicating that membrane fluidity was decreased in hypertensive men. Both plasma 8-iso-PG F2α and hs-CRP levels were significantly increased in hypertensive men compared with normotensive men. In addition, plasma plasma 8-iso-PG F2α levels were correlated with plasma hs-CRP levels. In contrast, plasma nitric oxide (NO)-metabolites were lower in hypertensive men than in normotensive men, and inversely correlated with plasma 8-iso-PG F2α and hs-CRP. The order parameter(S) of RBCs was correlated with plasma 8-iso-PG F2α and plasma hs-CRP, and inversely correlated with plasma NO-metabolites, suggesting that reduced membrane fluidity of RBCs might be associated with increased oxidative stress, inflammation and endothelial dysfunction. Multivariate regression analysis also showed that, after adjusting for general risk factors, both plasma 8-iso-PG F2α and hs-CRP were significant determinants of membrane fluidity of RBCs. The ESR suggests that associations of oxidative stress and inflammation might have a close correlation with impaired rheologic behavior of RBCs and microcirculatory dysfunction in hypertensive men.

关键词： Oxidative Stress 8-iso-prostaglandin F2α High-Sensitivity C-Reactive Protein Nitric Oxide Membrane Fluidity Electron Spin Resonance Hypertension

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Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

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International Journal of Clinical Medicine 2013年第1期4卷 58-65页

作者： Kazushi Tsuda Cardiovascular and Metabolic Research Center Kansai University of Health Sciences Osaka Japan 2Division of Cardiology School of Medicine Wakayama Medical University Wakayama Japan

Hyperhomocysteinemia and oxidative stress may be strongly linked to hypertension, atherosclerosis and other cardiovascular diseases. The present study was performed to investigate possible relationships among plasma total homocysteine, plasma 8-iso-prostaglandin F2α (8-isoPG F2α: an index of oxidative stress), and membrane fluidity (a reciprocal value of membrane microviscosity) in hypertension. We measured the membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin-labeling method. Membrane fluidity of RBCs was significantly decreased in hypertensive men compared with normotensive men. Plasma total homocysteine levels were significantly higher in hypertensive men than in normotensive men, and correlated with plasma 8-isoPG F2α. In contrast, plasma nitric oxide (NO)-metabolites (an index of endothelial function) were lower in hypertensive men than in normotensive men. The reduced membrane fluidity of RBCs was associated with increased total homocysteine and plasma 8-isoPG F2α levels and decreased plasma NO-metabolite levels. Multivariate regression analysis showed that, after adjusting for general risk factors, plasma total homocysteine and 8-isoPG F2α were significant determinants of membrane fluidity of RBCs, respectively. These results suggest that hyperhomocysteinemia and oxidative stress with endothelial dysfunction might have a close correlation with impaired rheologic behavior of RBCs and circulatory disorders in hypertensive men.

关键词： Homocysteine Oxidative Stress 8-iso-prostaglandin F2α Nitric Oxide Membrane Fluidity Red Blood Cell Electron Spin Resonance Hypertension

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