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Impact of 60 Days of 6° head down bed rest on Cardiopulmonary Function,and the Effects of Taikong Yangxin Prescription(太空养心方) as A Countermeasure

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Chinese Journal of Integrative Medicine 2014年第9期20卷 654-660页

作者：石宏志李勇枝唐志忠仲崇发范全春高建义刘军莲米涛赵爽李莹辉 State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center

Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.

关键词： 6^°head down bed rest weightlessness simulation cardiopulmonary function Taikong Yangxin Prescription

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