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A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder

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World Journal of Pediatrics 2022年第12期18卷 825-834页

作者： Mahasweta Chatterjee Sharmistha Saha Swagata Sinha Kanchan Mukhopadhyay Manovikas Biomedical Research and Diagnostic Centre Manovikas Kendra482 MadudahPlot I-24Sector JEM BypassKolkataWest Bengal700107India

Background The serotonin transporter(SERT),encoded by the solute carrier family 6 number 4(SLC6A4)gene,controls serotonin(5-HT)availability and is essential for the regulation of behavioral *** SLC6A4 genetic variants,5-HTTLPR and STin2,were widely investigated in patients with various neurobehavioral disorders,including attention deficit hyperactivity disorder(ADHD).Methods We analyzed the association of the 5-HTTLPR(L/S)and STin2(10/12)variants,plasma 5-HT,and 5-hydroxyindole acetic acid(5-HIAA),as well as SERT messenger RNA(mRNA)with ADHD in the eastern Indian *** families with ADHD probands(n=274)and ethnically matched controls(n=367)were recruited following the Diagnostic and Statistical Manual of Mental *** traits,executive function,and intelligence quotient(IQ)of the probands were assessed using the Conner's Parent Rating Scale–Revised,Parental Account of Children’s Symptoms(PACS),Barkley Deficit in Executive Functioning—Child and Adolescent Scale,and Wechsler Intelligence Scale for Children-III,*** obtaining informed written consent,peripheral blood was collected to analyze genetic variants,plasma 5-HT,5-HIAA,and SERT mRNA *** ADHD probands showed a higher frequency of the 5-HTTLPR“L”allele and“L/L”genotype(P5),lower 5-HIAA level,and higher SERT mRNA *** for behavioral problems and hyperactivity were higher in the presence of the“S”allele and“S/S”genotype,while executive deficit was higher in the presence of the“L”*** score was lower in the presence of the STin2“12”allele and L-12 *** Data obtained indicate a significant association of the serotoninergic system with ADHD,warranting further in-depth investigation.

关键词： Attention deficit hyperactivity disorder 5-Hydroxyindole acetic acid 5-serotonin 5-HTT-linked polymorphic region SERT mRNA

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Effect of 5-hydroxytryptamine Receptor in the Lower Esophageal Sphincter Regulation Mechanism

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Proceedings of Anticancer Research 2019年第6期3卷 5-14页

作者： Hefei Li Junfeng Liu Xixuan Zhang Zhiwei Lai Zhen Gao Chuntao Song Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityHebei 071000China Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityHebei 050011China

As a neurotransmitter and avascular active substance,the 5-hydroxytryptamine(5-HT,serotonin)is widely distributed in the central nervous system and surrounding *** 5-HT can play its role by acting on its corresponding 5-HT ***,the 5-HT receptor can be classified into seven,according to different signal transduction method of receptors,the 5-HT3 receptor belongs to the ligandgated ion channels,while other six 5-HT receptors are involved into the G protein-coupled receptors and play the biological role by binding to specific G protein-coupled receptors(GPCRs)on the surface of the cell *** 5-HT plays an important role in the brain-gut information transmission and studies showed that the physiological stimulations like having meals,and pathological stimulations like ischemia and stress could promote the release of the *** the gastrointestinal tract,the 5-HT is closely related to gastrointestinal sensitivity,gastrointestinal movement and secretion regulation,as well as many gastrointestinal dysfunction disorders,such as gastrointestinal power and visceral sensitivity abnormality and abnormalities of brain-gut axis.

关键词： 5-serotonin Lower esophageal sphincter Neurotransmitter

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