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Longitudinal Examination of Learning and Memory in Rats Following Adolescent Exposure to 3,4-Methylenedioxymethamphetamine or 5-Methoxy-N,N-Diisopropyltryptamine

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Journal of Behavioral and Brain Science 2017年第9期7卷 371-398页

作者： David M. Compton Kerri L. Dietrich Peniel Esquivel Corina Garcia Department of Psychology Donnelley Behavioral Neuroscience Laboratory Palm Beach Atlantic University West Palm Beach FL USA

A drug of abuse, Foxy or Methoxy Foxy gained popularity among recreational users as an alternative to MDMA (Ecstasy). Considerable research into the consequences of MDMA use is available, yet much remains unknown about the neurobiological consequences of Foxy use. In addition, research into the long-term neuropsychological repercussions associated with these two compounds remains incomplete. The goal of the present research was to explore the effects of MDMA or Foxy on cognitive processes associated with adolescent exposure considered over much of the lifespan. Here we investigated whether the reported effects following adolescent exposure resolved in early adulthood or continued throughout life. The protocol involved repeated doses of either MDMA or Foxy during the period defined as mid-adolescence (postnatal days 34 - 46) in rats, followed by the use of four series of learning and memory tasks repeated at different points in the rodent lifespan. At four time points in adulthood, the animals were trained and tested on a on a series of spatial and non-spatial memory tasks designed to assess the impact and severity of Foxy and MDMA. Oddly, MDMA-treated rats were impaired on a step down passive avoidance task. The performance of the drug-treated rats was markedly inferior to that of the control animals on more demanding water maze tasks, with some results suggesting a lack of flexibility in adapting to changing task demands. MDMA rats were the most impaired. While some persistent cognitive deficits were found, no significant group differences in serotonin or dopamine levels were found in any of the measured regions of the brain changes, cortical or subcortical. These results provide evidence for compromised neurocognition that continues long after drug exposure in the absence of any discernable changes in neurotransmitter levels. Several possible physiological and neurochemical mechanisms associated with these compounds requiring further study are also outlined.

关键词： MDMA Ecstasy 5-meo-dipt Foxy Spatial Learning Development Memory

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使用“0号胶囊”致幻后一同性恋者坠亡

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广东公安科技 2022年第2期30卷 79-80页

作者：古今平周品涛魏英率付英男武汉市公安局东新分局湖北武汉430074

“0号胶囊”主要成分是5-meo-dipt (5-甲氧基-N,N-二异丙基色胺)是一种新型毒品属色胺衍生物,俗称火狐狸、媚药,使用后会产生迷幻效应,毒副作用包括瞳孔放大、恶心、下颚紧闭、肌肉紧张过度、高血压及心跳过速等症状。根据国外文献记载... 详细信息

“0号胶囊”主要成分是5-meo-dipt (5-甲氧基-N,N-二异丙基色胺)是一种新型毒品属色胺衍生物,俗称火狐狸、媚药,使用后会产生迷幻效应,毒副作用包括瞳孔放大、恶心、下颚紧闭、肌肉紧张过度、高血压及心跳过速等症状。根据国外文献记载,有一位29岁男子为寻找性乐趣而使用5-meo-dipt,导致急性心脏衰竭死亡。另有多数案例均证实5-meo-dipt具有潜在致命性危险,国内鲜有使用后直接致死案例。本文报道一名21岁男性大学生因使用“0号胶囊”产生被迫害幻觉后从16楼窗户跳出坠亡的事件,藉此促使社会各界对该药物之危害性提高警觉。

关键词： 0号胶囊 5-meo-dipt 火狐狸迷幻剂致死危险

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