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Changes of Serotonin （5-ht）, 5-ht2a receptor, and 5-ht Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression

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Chinese Medical Journal 2015年第14期128卷 1905-1909页

作者： Mei-Yan Liu Yan-Ping Ren Wan-Lin Wei Guo-Xiang Tian Guo Li Department of Cardiology Beijing Anzhen Hospital Affiliated to Capital Medical University Beijing 100029 China Department of Geriatric-cardiovascular First Affiliated Hospital of Medical College Xi'an Shaanxi 710061 China Department of Cardiology Military General Hospital of Beijing PLA Beijing 100700 China Department of 4^th Cadres Ward Military General Hospital of Beijing PLA Beijing 100700 China

Background： To evaluate whether serotonin （5-ht）, 5-ht2a receptor （5-ht2aR）, and 5-ht transporter （serotonin transporter [SERT]） are associated with different disease states of depression, myocardial infarction （MI） and MI co-exist with depression in Sprague-Dawley rats. Methods： After established the animal model of four groups include control, depression, MI and MI with depression, we measured 5-ht, 5-ht2aR and SERT from serum and platelet lysate.Results： The serum concentration of 5-ht in depression rats decreased significantly compared with the control group （303.25 ± 9.99 vs. 352.98 ±13.73; P =0.000）, while that in MI group increased （381.78 ±14.17 vs. 352.98 ±13.73; P = 0.000）. However, the depression ＋ MI group had no change compared with control group （360.62 ±11.40 vs. 352.98 ±13.73; P = 0.036）. The changes of the platelet concentration of 5-ht in the depression, MI, and depression ＋ MI group were different from that of serum. The levels of 5-ht in above three groups were lower than that in the control group （380.40 ± 17.90, 387.75 ±22.28,246.40 ±18.99 vs. 500.29 ±20.91 ; P = 0.000）. The platelet lysate concentration of 5-ht2aR increased in depression group, MI group, and depression ＋ MI group compared with the control group （370.75 ±14.75,393.47 ±15.73,446.66 ±18.86 vs. 273.66 ±16.90; P= 0.000）. The serum and platelet concentration of SERT in the depression group, MI group and depression ＋ MI group were all increased compared with the control group （527.51 ±28.32, 602.02 ±23.32, 734.76 ±29.59 vs. 490.56 ±16.90; P 0,047, P = 0.000, P = 0.000 in each and 906.38 ±51.84, 897.33 ±60.34, 1030.17 ±58.73 vs. 708.62 ±51.15; P = 0.000 in each）. Conclusions： The concentration of 5-ht2aR in platelet lysate and SERT in serum and platelet may be involved in the pathway of MI with depression. Further studies should examine whether elevated 5-ht2aR and SERT may contribute to the biomarker in MI patients with depression.

关键词： 5-ht 5-ht2a receptor Depression Myocardial Infarction, Serotonin Transporter

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5-ht induces phrenic long-term facilitation via 5-ht2a receptor/PKC mechanism in anaesthetized rats:the critical role of the carotid body

5-HT induces phrenic long-term facilitation via 5-HT2A recep...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Margaret-T.T.WONG-RILEY Department of Cell Biology Neurobiology and AnatomyMedical College of WisconsinMilwaukeeUSA

＜正＞Objective Respiratory behavior expresses diverse forms of plasticity by altering breathing *** of respiratory neuroplasticity often leads to ***-term facilitation（LTF）,the most frequently studied model induced by episodic hypoxia to produce long-lasting enhancement of phrenic motor output,is thought to be serotonin 2A receptor（5-ht2aR）-*** studies have described 5-ht-induced prompt apnea in intact animals in vivo. However,the role of exogenous 5-ht in mediating respiratory neuroplasticity is less *** hypothesize that in vivo 5-ht challenge contributes to respiratory *** wished to explore a bolus of systemic 5-ht-induced phrenic nerve activity,and the underlying mechanisms of 5-ht2aR-protein kinase C（PKC） pathway and peripheral afferents that may contribute to 5-ht-mediated respiratory *** Systemic administration of serotonin hydrochloride,ketanserin tartarate（a selective 5-ht2aR antagonist） and staurosporine（a PKC inhibitor） were performed and phrenic nerve outputs were recorded in *** We found that a bolus of systemic 5-ht administration exerted an initial transient inhibition followed by marked facilitation,forming a biphasic pattern of phrenic nerve activity. （PNA） in artificially ventilated,midcervically vagotomized,and anaesthetized adult *** facilitatory phase represented the enhanced PNA that lasted for at least one hour after drug exposure,characterized as phrenic LTF（pLTF）.5-ht-induced biphasic pattern and pLTF were 5-ht2aR-dependent and coupled to PKC *** initial PNA inhibition was found to be nodose ganglion-associated,whereas the subsequent facilitation was carotid body-associated,establishing a peripheral inhibitory-facilitatory afferent *** of 5-ht/5-ht2aR and phospho-PKC isoforms/PKC substrate are consistent with the morphological evidence of existence of the 5-ht-5-ht2aR-PKC mechanism in the nodose ganglion and the carotid

关键词： 5-ht 5-ht2a receptor PKC respiratory neuroplasticity phrenic nerve activity

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Serotonin-2A receptor-activated PKCtheta pathway in mediating longterm facilitation in rats with chronic intermittent hypoxia - the pre-Btzinger complex as a critical site for respiratory plasticity

Serotonin-2A receptor-activated PKCtheta pathway in mediatin...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yingying LIU,Jinping LIU,Xiaoyan WEI,Caiyun ZHAO,Haojun WANG,Jianhong DUAN,Sanjue HU,Gong JU Institute of Neurosciences,The Fourth Military Medical University,Xi''an,710032,China

＜正＞Respiratory behavior expresses diverse forms of plasticity by alterations in breathing *** of respiratory plasticity often leads to diseases,such as sudden infant death syndrome or obstructive sleep ***-term facilitation（LTF） is the most frequently studied model for respiratory *** intermittent hypoxia（AIH）,three to five short-term hypoxia episodes,induces phrenic LTF（pLTF）,whereas chronic intermittent hypoxia（CIH）,lasting for days or weeks’ stimulus episodes,evokes additional neuroplasticity and augmented *** previous studies,however,were mostly concentrated on phrenic neuroplasticity in high-cervical spinal *** pre-B（o|¨）tzinger complex（pre-B（o|¨）tC）,a critical kernel of respiratory rhythmogenesis in the ventrolateral medulla oblongata,has been obscure until *** established a CIH pLTF model through hypobaric hypoxia in adult *** goal was to determine whether the pre-B＆ouml;tC is required for ***-induced CIH rats generated the augmentation of the short-term hypoxic phrenic response and the enhanced pLTF.5-ht2a receptors in the pre-B（o|¨）tC were found localized to sites consistent with active internalization and externalization（re-sensitivity） in the CIH rats and not in ***-protein kinase C（PPKC） theta isoform and P-PKC substrates were highly expressed in the pre-B（o|¨）tC in CIH *** close association of P-PKCtheta with the postsynaptic membrane was especially *** application of ketanserin,a 5-ht2a receptor specific antagonist,abolished pLTF in CIH rats,and PKCtheta-pseudosubstrate,a PKCtheta inhibitor,blocked pLTF in most CIH rats *** particular,a full abolishment of phrenic nerve activity was found in some CIH rats receiving both ketanserin and PKCtheta-pseudosubstrate,indicating a strengthened effect of 5-ht2a receptor and PKCtheta on *** on the neurochemical evidence of highly-activated 5-ht2a receptors and enhanced expressions of P-PKCtheta and

关键词： long-term facilitation chronic intermittent hypoxia 5-ht2a receptor PKCtheta pre-Btzinger complex rat

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