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5-aminolevulinic acid against strawberry Fusarium wilt:Bidirectional regulation of biocontrol agents and pathogens

Horticultural Plant Journal 2024年第6期10卷 1349-1361页

作者： Hao Yang Jianting Zhang Haiwen Zhang Rongxiang Cao Donglan Tang Liangju Wang College of Horticulture Nanjing Agricultural UniversityNanjingJiangsu 21095China Institute of Nanjing Agricultural Sciences Jiangsu Academy of Agricultural SciencesNanjingJiangsu 210046China

Strawberry Fusarium wilt (SFW) is a systematic soil-borne disease caused by Fusarium oxysporum *** (Fof),which infects the vascular bundles,blocking water and nutrient transport from roots to the *** is a severe pathogen which spreads rapidly and destroys strawberry *** a way to control this disease is of great scientific value and practical *** this study,three fungi were isolated from the vascular tissues of sick strawberries in the *** DNA sequencing,they were identified as Fof,Aspergillus fumigatus and Trichoderma harzianum,respectively,among which the first two are pathogens and the third is a *** fungi were controlled by thiophanate-methyl (TM),a commercial *** PDA medium,20 mg·L^(-1)5-aminolevulinic acid (ALA),a natural non-protein amino acid,promoted *** proliferation,but inhibited Fof and *** confrontation test,the growth of Fof or *** was inhibited by *** and exogenous ALA promoted *** growth but significantly inhibited the pathogen *** three species of fungi were separately or combinedly inoculated on healthy strawberry plants,*** promoted plant growth and development while Fof or *** caused growth retardation,where Fof directly caused leaf yellowing and plant *** the plants inoculated with different fungus were treated with ALA,the results turned out that ALA alleviated SFW symptoms by bidirectionally promoting *** proliferation and inhibiting Fof and ***,ALA might be used in comprehensively controlling SFW in strawberry industry.

关键词： 5-aminolevulinic acid Antagonistic effect Disease control Fusarium oxysporum f.sp.fragaria(Fof) Strawberry Fusarium wilt(SFW) Trichoderma harzianum

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Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-aminolevulinic acid and Its Derivatives

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Chemical Research in Chinese Universities 2010年第1期26卷 66-69页

作者： QIU Xue-peng KOSOBE Toshiyuki KAWASHIMA Norimichi Faculty of Biomedical Engineering Toin University of Yokohama 1614 Kurogane-cho Aoba-ku Yokohama 225-8502 Japan Laboratory of Polymer Engineering Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy（PDT） of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PplX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates（C5-S, C6-S, C8-S） exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application ofPplX-mediated PDT to cancer cell.

关键词： Photodynamic therapy Methanesulfonate salt 5-aminolevulinic acid Derivative Cancer cell

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Impacts of Fe2+on 5-aminolevulinic acid(ALA)biosynthesis of Rhodobacter sphaeroides in wastewater treatment by regulating nif gene expression

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Journal of Environmental Sciences 2018年第8期30卷 11-19页

作者： Shuli Liu Zhihong Zheng Jingxi Tie Jia Kang Guangming Zhang Jie Zhang School of Environmental and Municipal Engineering North China University of Water Resources and Electric PowerZhengzhou 450000China Henan Key Laboratory of Water Environment Simulation and Treatment Zhengzhou 450046China Henan Engineering Research Center of Water Pollution and Soil Damage Remediation Zhengzhou 450046China School of Environment and Resource Renmin University of ChinaBeijing 100872China School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090China

This study aimed to increase bacterial growth and 5-aminolevulinic acid（ALA） biosynthesis of Rhodobacter sphaeroides in wastewater treatment through adding ferrous ion（ Fe2＋）. Results demonstrated that Fe2＋ effectively enhanced the biomass production and ALA yield of R. sphaeroides. Moreover, the optimal Fe2＋ dosage was found to be 400 μmol/L, which was associated with the highest biomass of 4015.3 mg/L and maximum ALA yield of 15.9 mg/g-dry cell weight（mg/g-DCW）. Mechanism analysis revealed that Fe2＋ vastly improved Adenosine Triphosphate（ATP） production by up-regulating the nif gene expression, and increasing ATP enhanced the biomass and ALA yield by supplying energy for bacterial growth and ALA biosynthesis, respectively. Correlation analysis showed that the ALA and ATP yields had positive relation with nifA and nifU gene expression. In addition, the nifA and nifU gene expression displayed high consistency of co-transcription at the optimal Fe2＋ dosage.

关键词： Ferrous ion 5-aminolevulinic acid Rhodobacter sphaeroides ATP production nif genes Up-regulation

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A Photosensitivity Insecticide, 5-aminolevulinic acid, Exerts EffectiveToxicity to Oxya chinensis (Orthoptera: Acridoidea)

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Agricultural Sciences in China 2011年第7期10卷 1056-1063页

作者： YANG Mei-ling YIN Kun GUO Ya-ping MA En-bo ZHANG Jian-zhen Research Institute of Applied Biology Shanxi University Taiyuan 030006 P.R.China Environmental Monitoring of China Beijing 100012 P.R.China School of Life Science and Technology Shanxi University Taiyuan 030006 P.R.China

5-aminolevulinic acid （ALA）, a major photosensitivity insecticide, has attracted increasing attention as a new type of highly efficient, environmental friendly pesticide to be used to control the pest. To examine whether or not ALA acts effectively to grasshopper, Oxya chinensis and elucidate the detoxification mechanism of ALA, the susceptibility to ALA was assessed in O. chinensis and two major metabolic detoxification enzymes including glutathione S-transferases （GSTs） and general esterases （ESTs）-specific activities were compared in different development stages and different body sections of O. chinensis treated by ALA and the control. The results showed that the ALA exhibited obvious toxicity to the grasshopper in different development stages. In the low-dose treatment （0.0597 mmol L-1）, the mortalities of O. chinensis reached a significant level （55.5% in the 1st instar nymphs, 61.4% in the 2nd instar nymphs, 71.4% in the 3rd instar nymphs, and 64.4% in the 4th instar nymphs. But, there was no dose-dependent toxic effect. Thereby, we proposed that ALA has the potential for acting as photosensitivity insecticide for controlling O. chinensis. GSTs activity assays using CDNB and DCNB as substrates indicated that the thorax and abdomen of the different instar nymphs treated by ALA showed 1.52-5.56 fold significantly increased GSTs activities compared with the control. However, for the ESTs-specific activity assay, there was no significant difference between O. chinensis treated by ALA and the control within different instar nymphs, when a-NA, a-NB and b-NA were used as substrates. Therefore, GSTs-mediated metabolic detoxification as evidenced by significantly increased GSTs activities might contribute to protect against oxidative damage and oxidative stress by ALA in O. chinensis.

关键词： 5-aminolevulinic acid toxicity glutathione S-transferases general esterases Oxya chinensis

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5-aminolevulinic acid Improves Water Content and Reduces Skin Wrinkling

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Health 2020年第7期12卷 709-716页

作者： Yuna Naraoka Ailing Hu Takuji Yamaguchi Norio Saga Hiroyuki Kobayashi Department of Hospital Administration Graduate School of Medicine Juntendo University Tokyo Japan Center for Advanced Kampo Medicine and Clinical Research Graduate School of Medicine Juntendo University Tokyo Japan Institute of Sports Science & Medicine Teikyo University Tokyo Japan

5-aminolevulinic acid (ALA) is a natural amino acid that is used as a raw material for the biosynthesis of red-blood-cell hemoglobin in humans and animals. ALA is the subject of research in a wide range of human health care fields, including skin care and medicine. This study investigated whether and to what extent cosmetics containing ALA (skin lotions and creams) improved facial-skin condition in women. As such, a double-blind controlled experiment was conducted among 45 women aged 47.0 ± 1.72 years. Participants were divided into two intervention groups, including those who used cosmetics containing ALA (C-ALA, n = 22) and those who used cosmetics without ALA (W-ALA, n = 23). Specifically, participants were instructed to use their assigned cosmetics twice per day (morning and evening) after washing their faces before each application. Inner skin condition and skin-water content were evaluated via VISIA-Evolution and Multi Display Devices at baseline and after four and eight weeks of use. The experiment lasted for a total of eight weeks. A baseline comparison at week four showed that skin moisture content increased significantly for the C-ALA group (p = 0.021). Further, wrinkling significantly decreased at week four among participants in the C-ALA group who were evaluated as having many wrinkles at baseline (p = 0.034). These findings suggest that cosmetics containing ALA have moisturizing effects and reduce wrinkling caused by dryness.

关键词： 5-aminolevulinic acid Wrinkle Cosmetics Facial Skin

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5-aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway

5-Aminolevulinic acid combined with sodium ferrous citrate a...

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第十一届全国免疫学学术大会

作者： Zhu Ping Zhao Mingyi Guo Huiming Chen Jimei Wang Jinju Huang Huanlei Zheng Shaoyi Hei Mingyan Li Jiaxin Huang Shuai Li Jiani Ma Xiaotang Chen Yanfang Zhao Lingling Zhuang Jian Guangdong Cardiovascular Institute Guangdong General HospitalGuangdong Academy of Medical Sciences Department of Pharmacology and Toxicology Boonshoft School of MedicineWright State University Department of Pediatrics the Third Xiangya HospitalCentral South University Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases Affiliated Hospital of Guangdong Medical College

Objectives: Hydrogen peroxide(H2O2) causes cell damage via oxidative stress. Heme oxygenase-1(HO-1) is an antioxidant enzyme that can protect cardiomyocytes against oxidative stress. In this study, we investigated whether the heme precursor 5-aminolevulinic acid(5-ALA) with sodium ferrous citrate(SFC) could protect cardiomyocytes from H2O2-induced hypertrophy via modulation of HO-1 expression. Methods: HL-1 cells pretreated with/without 5-ALA and SFC were exposed to H2O2 to induce a cardiomyocyte hypertrophy model. Hypertrophy was evaluated by planar morphometry, 3H-leucine incorporation, and RT-PCR analysis of hypertrophy-related gene expressions. Reactive oxygen species(ROS) production was assessed by 5/6-chloromethyl-2=,7=-ichlorodihydrofluorescein diacetate acetylester. HO-1 and nuclear factor erythroid 2-related factor 2(Nrf2) protein expressions were analyzed by Western blot. In our experiments, HL-1 cells were transfected with Nrf2 siRNA or treated with a signal pathway inhibitor. Results: 1) ROS production, cell surface area, protein synthesis, and expressions of hypertrophic marker genes, including atrial natriuretic peptide, brain natriuretic peptide, atrial natriuretic factor, and-myosin heavy chain, were decreased in HL-1 cells pretreated with 5-ALA and SFC. 2) 5-ALA and SFC increased HO-1 expression in a dose- and timedependent manner, associated with upregulation of Nrf2. Notably, Nrf2 siRNA dramatically reduced HO-1 expression in HL-1 cells. 3) ERK1/2, p38, and SAPK/JNK signaling pathways were activated and modulate 5-ALA- and SFCenhanced HO-1 expression. SB203580(p38 kinase), PD98059(ERK), or SP600125(JNK) inhibitors significantly reduced this effect. In conclusion, our data suggest that 5-ALA and SFC protect HL-1 cells from H2O2-induced cardiac hypertrophy via activation of the MAPK/ Nrf2/HO-1 signaling pathway. Conclusions: In this study, we have shown that 5-ALA and SFC pretreatment protected against H2O2-induced cardiomyocyte hypertrophy through

关键词： 5-aminolevulinic acid heme oxygenase-1 nuclear factor erythroid 2-related factor 2 cardiomyocyte

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5-aminolevulinic acid combined with sodium ferrous citrate ameliorated lupus nephritis in a mouse chronic graft-versus-host disease model

5-aminolevulinic acid combined with sodium ferrous citrate a...

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第十四届全国免疫学学术大会

作者： CHI LIU 四川省人民医院肾内科

Systemic lupus erythematosus(SLE) is a systemic autoimmune disease characterized by the abnormal activation of immune cells and hypersecretion of autoantibodies and causes irreversible chronic damage,such as lupus *** graft-versus-host-disease(cGvHD) in mice induced by the injection of parental mouse lymphocytes into F1 hybrids leads to a disease similar to SLE.5-aminolevulinic acid(5-ALA) is a key progenitor of heme,and its combination with sodium ferrous citrate(SFC) can up-regulate the heme oxygenase(HO-1) expression,resulting in an anti-inflammatory *** hypothesized that treatment with 5-ALA/SFC could ameliorate lupus nephritis in a mouse cGvHD *** results showed that 5-ALA/SFC treatment significantly decreased the serum autoantibodies,blood urea nitrogen(BUN) and creatinine(Cre) levels,reduced kidney inflammatory dendritic cells(DCs) and B cell activation,and increased the regulatory T cells(Tregs) at nine ***,5-ALA/SFC treatment decreased the mRNA expression of inflammatory genes in the *** addition,we also found that 5-ALA/SFC treatment increased the HO-1 expression on donor-derived DCs and Tregs concurrently,increased the number of Tregs,and reduced the population of activated DCs,B cells and CD8T cells at three weeks(early stage of the disease).We thus identified a novel role of 5-ALA/SFC for therapeutically improving the symptoms of lupus nephritis in a mouse cGvHD model and expanded the current understanding of how this immunoregulatory agent can be used to generate beneficial immune responses and treat autoimmune disease.

关键词： systemic lupus erythematosus chronic graft-versus-host-disease 5-aminolevulinic acid sodium ferrous citrate CD8+T cell

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Improved 5-aminolevulinic acid Production with Recombinant Escherichia coli by a Short-term Dissolved Oxygen Shock in Fed-batch Fermentation

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Chinese Journal of Chemical Engineering 2013年第11期21卷 1291-1295页

作者：杨俊朱力傅维琦林逸君林建平岑沛霖 Key Laboratory of Biomass Chemical Engineering of Ministry of Education Departnaent of Chemical and BiologicalEngineering Zhejiang University Hangzhou 310027 China Center for Systems Biology University of Iceland Reykjavik Iceland

5-aminolevulinic acid （ALA） is a common precursor for tetrapyrrole compounds in all kinds of organ isms and has wide applications in agriculture and medicines. In this study, a new strategy, i.e. short-term dissolved oxygen （DO） shock during aerobic fermentation, was introduced to produce 5-aminolevulinic acid with a recombi-nant E. coli. Effects of duration time of DO shock operation on plasmid concentration, intracellular ALA synthase （ALAS） activity and ALA production were investigated in Erlenmeyer shake flasks. The results indicated that both ALAS activity and ALA yield were enhanced in an anaerobic operation of 45 rain in the early exponential phase during fermentation, while they decreased when the anaerobic operation time was further increased to 60 rain. The DO shock protocol was confirmed with the fed-batch fermentation in a 15 L fermenter and the ALA production achieved 9.4 g.L-1 （72 mmol.L-1）, which is the highest yield in the fermentation broth reported up to now.

关键词： 5-aminolevulinic acid synthase activity dissolved oxygen shock fed-batch fermentation recombinantE. coli

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Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer

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World Journal of Gastroenterology 2015年第29期21卷 8769-8775页

作者： Tsutomu Namikawa Tomoaki Yatabe Keiji Inoue Taro Shuin Kazuhiro Hanazaki Department of Surgery Kochi Medical School Nankoku Department of Anesthesiology Kochi Medical School Nankoku Department of Urology Kochi Medical School Nankoku

5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources.

关键词： Fluorescence imaging 5-aminolevulinic acid Photodynamic diagnosis Photodynamic therapy Gastric cancer

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Effects of 5-aminolevulinic acid (ALA) on Zinnia hybrida Growth and Phytoremediation Effects in Oil-Contaminated Soil

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Journal of Agricultural Chemistry and Environment 2020年第3期9卷 97-106页

作者： Takamitsu Kai Hiromi Ikeura Ariaki Ayanokoji Masahiko Tamaki Kurokawa Field Science Center Meiji University Kawasaki Japan Life and Environmental Sciences Department Shimane University Matsue Japan School of Agriculture Meiji University Kawasaki Japan

In this study, we compared plant height, weight, soil TPH concentration, and soil DHA level after 18 weeks of Zennia hybrida cultivation with four different concentrations of 5-Aminolevulinic acid (ALA)-based liquid fertilizer: 1500-fold, 5000-fold, and 8000-fold dilutions, along with a non-treatment control of diluted ALA. The plants of ALA-treated were significantly taller than the non-treatment control. The plants of ALA-treated plants were higher in shoot fresh weight, shoot dry weight, and root dry weight than the non-treatment control. The plot of ALA-based liquid fertilizer with the 5000-fold dilution was significantly highest in shoot fresh weight, shoot dry weight, and root dry weight. ALA-treated plants were lower in the soil Total Petroleum Hydrocarbon (TPH) concentration than the non-treatment control. The plot of ALA-based liquid fertilizer with the 5000-fold was significantly lowest in the TPH concentration. In addition, ALA-treated plants were higher in the soil dehydrogenase activity (DHA) than the non-treatment control. The plot of ALA-based liquid fertilizer with the 5000-fold was significantly highest in the TPH concentration. This study indicated that ALA-applied zinnia-grown oil-contaminated soil is more effective than not. The remediation in oil-contaminated soil with ALA-based liquid fertilizer is more effective than the non-treatment control;furthermore, ALA application with 5000-fold dilution was most suitable in oil-contaminated soil among other plots.

关键词： Phytoremediation Zinnia 5-aminolevulinic acid Soil Total Petroleum Hydrocarbon (TPH) Concentration Soil Dehydrogenase Activity (DHA)

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