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Vitamin B6 and colorectal cancer:Current evidence and future directions

World Journal of Gastroenterology 2013年第7期19卷 1005-1010页

作者： Xue-Hong Zhang Jing Ma Stephanie A Smith-Warner Jung Eun Lee Edward Giovannucci Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMA 02115United States Department of Nutrition and Department of EpidemiologyHarvard School of Public HealthBostonMA 02115United States Department of Food and Nutrition Sookmyung Women's UniversitySeoul 140742South Korea

Colorectal cancer remains the third most common cancer in both women and men *** modifiable dietary factors is crucial in developing primary prevention *** B6 is involved in more than 100 coenzyme reactions,and may influence colorectal cancer risk in multiple ways including through its role in one-carbon metabolism related DNA synthesis and methylation and by reducing inflammation,cell proliferation,and oxidative *** studies of dietary or dietary plus supplementary intake of vitamin B6 and colorectal cancer risk have been inconsistent with most studies reporting nonsignificant positive or inverse ***,published studies of plasma pyridoxal 5'-phosphate(the active form of vitamin B6) levels consistently support an approximately 30%-50% reduction in risk of colorectal cancer comparing high with low *** reasons for the discrepancy in the results between dietary-based and plasma-based studies remain *** unresolved questions include the effects of vitamin B6 intake in early life(i.e.,childhood or adolescence) and of suboptimal vitamin B6 status on colorectal cancer risk,whether the associations with vitamin B6 differ across molecular subtypes of colorectal cancer,and whether the vitamin B6-colorectal cancer association is modified by genetic variants of one-carbon metabolism.

关键词： Vitamin B6 Plasma pyridoxal 5’-phosphate Colorectal cancer Adenoma Incidence Case-control study Cohort study Randomized controlled trial Epidemiology

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