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Sexual,physical and overall adverse effects in patients treated with 5a-reductase inhibitors:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 390-397页

作者： Jun-Jie Zhang Xiao Shi Ting Wu Meng-Da Zhang Jin Tang Guang-Ming Yin Zhi Long Le-Ye He Lin Qi Long Wang Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Cardiovascular Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Postfinasteride syndrome(PFS)is a term coined to characterize a constellation of reported undesirable sexual,physical,and neuropsychiatric side *** the present study,we conducted the meta-analysis to demonstrate whether the use of 5α-reductase inhibitors(5ARIs)increases the risk of PFS-like adverse effects.A search of studies published until May 10,2020,was performed using PubMed,EMBASE,and the Cochrane *** included randomized controlled trials with at least one comparison between male patients receiving 5ARIs versus placebo for the treatment of benign prostatic hyperplasia(BPH)or androgenetic alopecia(AGA),and identified 34 studies from 28 articles that met our eligibility *** the random-effects model,the overall use of 5ARIs exhibited a 1.87-fold risk of PFS-like adverse effects during the trial(95%confidence interval[CI]:1.64-2.14).Regarding specific types of adverse effects,the use of 5ARIs had a 1.89-fold risk of sexual adverse effects(95%CI:1.74-2.05)and was associated with an increased risk of physical adverse effects(relative risk[RR]:1.31,95%CI:0.80-2.15),albeit without statistical *** meta-analysis helped to better define the adverse effects caused by *** concluded that the overall use of 5ARIs significantly increased the risk of PFS-like adverse effects in men with AGA or BPH during *** awareness of and education on the PFS-like adverse effects are necessary for clinicians.

关键词： 5α-reductase inhibitors adverse effects androgenetic alopecia benign prostatic hyperplasia postfinasteride syndrome

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