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Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency

Pediatric Investigation 2021年第4期5卷 249-254页

作者： Ying Liu Lijun Fan Xiaoling Wang Chunxiu Gong Department of Pharmacy Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Endocrinology Genetics and MetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Children with 5-alpha-reductase deficiency(5α-RD)and hypospadias present with micropenis,which makes it difficult to obtain sufficient tissue for urethral ***:We investigated the therapeutic effects of oral testosterone undecanoate and established a standard androgen treatment protocol for patients with 5α-RD with ***:Patients with 5α-RD were treated with oral testosterone undecanoate for 3 months as a *** patients were treated with no more than 3 *** the penile length(PL)reached 2.5 cm(the minimum criterion for surgery)or greater than or equal to−2.5 standard deviations(SDs)(lower limit of normal),testosterone undecanoate was considered to be ***:The median age of 90 patients with 5α-RD was 1.7 years(0.9,3.1 years).The baseline PL was 1.9±0.6 cm before *** the end of the first course,the PL of 63 patients(70%)reached 2.5 cm,and 49 patients(54%)reached greater than or equal to−2.5 *** two treatment courses,the PL of 81 patients(90%)reached 2.5 cm,and 90 patients(100%)reached greater than or equal to−2.5 *** three courses,the PL of all patients reached 2.5 cm,and all patients reached a PL greater than or equal to−2.5 *** abnormal increase was observed in height-SD score,weight-SD score,or ratio of bone age to chronological age during the 1-3-year ***:After 3-9 months of treatment,PL increased to the target *** severe adverse reactions were observed during *** undecanoate was safe and effective in children with 5α-RD with micropenis.

关键词： 5α-reductase deficiency Micropenis Testosterone undecanoate Treatment Penile

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