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时代英语（初中） 2018年第4期 41-46,78-79页

Green Chemistry Approach to Fast and Highly Efficient One-Pot Synthesis of Bis-Isoxazolyl-1,2,5,6-Tetrahydro Pyridine-3-Carboxylates

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Green and Sustainable Chemistry 2013年第2期3卷 9-18页

作者： Eligeti Rajanarendar Kammari Thirupathaiah Saini Rama Krishna Baireddy Kishore Department of Chemistry Kakatiya University Warangal India

The synthesis of the bis-isoxazolyl-1,2,5,6-tetrahydro pyridine-3-carboxylates is achieved in high yield without the production of toxic waste products by using room temperature ionic liquid (RTILs) triethyl ammonium ... 详细信息

关键词： Bis-Isoxazolyl-1 2 5 6-Tetrahydro Pyridine-3-Carboxylates Green Synthesis

Module 5 The Conquest of the Universe

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时代英语（高三版） 2019年第4期 34-38,80页

本模块知识网络词汇短语园地1. accustomedadj.习惯的搭配:be accustomed to (doing) sth=be used to (doing) sth习惯于(做)某事I’m accustomed to the school life here now.现在我习惯这儿的学校生活了。I have been accustomed to ... 详细信息

关键词： Module 5 The Conquest of the Universe witness

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SIRT5调节剂的荧光筛选法研究

中国新药杂志 2014年第15期23卷 1795-1800页

作者：李燕崔珺刘亭李勇军兰燕宇王爱民王永林何彬贵阳医学院基础医学院贵阳550004 贵阳医学院民族药与中药开发应用教育部工程研究中心贵阳550004 贵阳医学院药学院贵阳550004 贵阳医学院贵州省药物制剂重点实验室贵阳550004

目的:鉴于高通量筛选方法是发现Sirtuin调节剂的重要手段,拟通过组蛋白去乙酰化酶SIRT5去琥珀酰化酶活的最新发现,开发出SIRT5酶活的"直接荧光测定法",并探讨其在筛选SIRT5特异型抑制剂方面的应用。方法:设计、合成了带有香豆素荧光基... 详细信息

目的:鉴于高通量筛选方法是发现Sirtuin调节剂的重要手段,拟通过组蛋白去乙酰化酶SIRT5去琥珀酰化酶活的最新发现,开发出SIRT5酶活的"直接荧光测定法",并探讨其在筛选SIRT5特异型抑制剂方面的应用。方法:设计、合成了带有香豆素荧光基团的琥珀酰多肽底物,通过条件优化,我们建立了SIRT5调节剂的荧光筛选方法,再结合SIRT1/2/3活性的二次筛选,可以发现SIRT5的特异型调节剂。结果与结论:建立了SIRT5调节剂的荧光筛选方法,为最终SIRT5靶向治疗的药物发现奠定基础。

关键词：组蛋白去乙酰化酶 Sirtuin 5 调节剂荧光筛选方法

Possible Geological Reason for the Missing of the Oligocene Section in Sector (5) and Its Vicinity, Deryanah-Al Abyar Area, Al Jabal Al Akhdar, NE Libya

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Open Journal of Geology 2013年第4期3卷 322-329页

作者： Omar B. Elfigih Hamza S. Melad Department of Earth Sciences Faculty of Science University of Benghazi Benghazi Libya

The existing stratigraphic framework of the Eocene-Miocene in the study area (sector 5) shows limited temporal stratigraphic and structural resolution. Using this framework, it is difficult to unravel the influence of possible local tectonic movements and eustatic sea level changes on sedimentation. The precise influence of the onset of the possible Late Eocene-Early Oligocene orogenic phase, which caused inversion and uplift in the study area (sector 5), is also dubious as a result of the limited data. To improve the correlations and recognition of the Eocene to Oligocene successions in the area in question (from sector 1 to sector 8), a new stratigraphic interpretation, based on correlated lithostratigraphic columns from different outcrops, is presented. The changes in sedimentation and tectonic events in the study area can be correlated to time-equivalent sea level changes and tectonic uplift in Al Jabal Al Akhdar area, which suggests that the processes causing the sedimento/structural activity are of regional importance.

关键词： Sector 5 Oligocene Inversion Uplift Stratigraphic Correlation

Analyzing the Impact of Bapco 5 MW Solar PV Grid-Connected Project on Bahrain’s Outlook for Energy-Mix Production

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International Journal of Modern Nonlinear Theory and Application 2019年第3期8卷 72-91页

作者： Naser Waheeb Alnaser Waheeb Essa Alnaser Department of Architecture and Interior Design College of Engineering University of Bahrain Zallaq Kingdom of Bahrain Department of Physics College of Science University of Bahrain Zallaq Kingdom of Bahrain

The impact of Bapco 5 MW solar PV grid-connected project on Bahrain’s outlook for clean energy and energy-mix production was analyzed since solar electricity obtained from PV installation is considered as a non-linear system. Several positive impacts were counted. These impacts were on business, economy, environment, research, green jobs creation and rooftop installation and other large-scale installation. This project had attracted public, investors, developers to invest in similar projects in the Kingdom of Bahrain;especially it is an environmentally friendly and smart technology. This innovative smart grid-connected 5 MW solar PV power plant is enough to electrify 500 houses @ 10 kW and had answered lots of frustrating questions such as the effect of dust on PV performance, need of man-made cleaning compared to naturally cleaned PV panels, reliability of the system, greenhouse gases reduction and pay-back period.

关键词： Solar PV Bapco 5 MW Grid Connected Smart PV Dust Accumulation

Synthesis and Characterization of 2,2’-Bipyridyl-5,5’-Dialdehyde Schiff Bases from O,S,N and F-Containing Amines

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International Journal of Organic Chemistry 2015年第1期5卷 29-36页

作者： Md Rejaul Hoq Mohammad R. Karim Md. Arifuzzaman Aminul H. Mirza Department of Chemistry Tennessee State University Nashville TN USA Department of Chemistry Iowa State University Ames IA USA Chemistry Faculty of Science Universiti Brunei Darussalam Jalan Tungku Link Brunei Darussalam

Design and synthesis of organic chelating agents containing nitrogen and sulfur as donor atoms and their metal complexes is an interesting field of research for their different types of activities. The bi-dentate N,N chelating agent such as 2,2-Bipyridal has been playing a vital role in synthetic and medicinal chemistry. 2,2-Bipyridal has been used to prepare many mixed-ligand complexes. Different ligand complexes prepared from 2,2-Bipyridyl are used in different areas such as molecular catalysis, solar energy conversion, calorimetric analysis, herbicides, molecular recognition, self-assembly, antineoplastic agents, and nucleic acid probes. Another important property of these types of compounds is the triplet state photosensitizing character of bipyridyl nucleus, which is shown in metal complexes. It is also found that compounds containing O,S,N atoms have received considerable attention because of their pharmacological studies like anticancer, antibacterial, and antitumour activities. Therefore, it has been decided to synthesize Schiff bases derived from 2,2’- bipyridyl-5,5’-dicarbaldehyde compounds with O,S,N and F-containing amines and study their antibacterial properties. Several new Schiff bases have been synthesized and fully characterized by spectral data. This paper presents the synthesis and characterization of newly designed Schiff bases.

关键词： 2 2’-Bipyridyl Schiff Base O S N-Containing Amines 5 5’-Dicarbaldehyde Bidentate

Tectono-Sedimentary Evolution of the Offshore Hydrocarbon Exploration Block 5, East Africa: Implication for Hydrocarbon Generation and Migration

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Open Journal of Geology 2018年第8期8卷 819-840页

作者： Ezekiel J. Seni Gabriel D. Mulibo Giovanni Bertotti Department of Geology University of Dar es Salaam Dar es Salaam Tanzania Department of Geoscience and Civil engineering Deft University of Technology Delft The Netherland

Sedimentary deposits in Block 5, offshore Tanzania basin have been imaged using two-dimensional (2D) seismic data. The seismic data and well data reveal four tectonic units representing different tectonic events in relation to structural styles, sedimentation and hydrocarbon potential evolved in Block 5. Results show that during Early to Late Jurassic, Block 5 was affected by the break-up of Gondwana and the drifting of Madagascar as evidenced by patterns of sediments and structural features. The chaotic and discontinuous reflectors are characteristics features on the sediments pattern indicating a possible transitional setting following the breakup of Gondwana. From the Late Cretaceous, Block 5 sits in more stable subsiding sag as the consequence of the high thermal subsidence. The period displayed continuous parallel reflectors with few markable faults. This was followed by the late post rift sedimentation that occurred after Middle Eocene Unconformity characterized by high wavy and sub parallel reflectors. The evolution of Block 5 through major tectonic events reveals a more complete petroleum system towards the south. Thus, Block 5 responded in both space and time to a complex interplay between tectonics and sedimentation. This indicates that structural styles and associated features are potential control for hydrocarbon generation and migration.

关键词： Offshore Tanzania basin Block 5 Tectonics Sedimentation Hydrocarbon East Africa

Baculovirus Mediated Experimental Research on Targeted Egr1-Kringle 5 Gene Radiotherapy in Lung Adenocarcinoma

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Journal of Cancer Therapy 2012年第4期3卷 397-405页

作者： Haoping Xu Rui Guo Biao Li Department of Nuclear Medicine Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Objective: To investigate the feasibility of temporally and spatially restricted Kringle5 expression induced by radiation, as well as the dual effect of radiotherapy and antiangiogenic therapy in lung adenocarcinoma in vitro. Methods: We first constructed recombinant baculovirus vectors containing Egr1 promoter and human plasminogen Kringle5 gene (rhK5), then transfected them into lung adenocarcinoma cells (A549). Transfect efficiency of the baculovirus for gene transfer in A549 cells and the activity of Egr1 promoter induced by X-radiation were detected by fluorescence microscopy. The rhK5 mRNA transcription and rhK5 protein expression were detected by Real-time PCR and Western blot assay, respectively. The apoptosis asssay of human umbilical veins endothelial cells (HUVEC) was analyzed by flow cytometry. Results: The recombinant baculovirus were successfully transfected into A549 and HUVEC cells. As for the temporal regulation, the rhK5 mRNA transcription and rhK5 protein expression were elevated with the irradiation time significantly. And the HUVEC apoptotic percentage increased in relation to the irradiation time as well. As for the spatial regulation, rhK5 mRNA transcription level of A549 cell lines transfected with recombinant baculovirus Egr1-K5 was significantly higher than that of control groups after the same dose of X-radiation. When we analyzed the dose and frequency of X-radiation, no difference was observed among each dose after continuously three-times of irradiation. Conclusion: Baculovirus-mediated Egr1-K5 can be used in gene radiotherapy for its temporary and spatial controllable rhK5 expression by X-radiation and the consequent HUVEC apoptosis in vitro study. And low dose and more times of irradiation might be more effective. It would provide a promising way for the tumor treatment.

关键词： Radiotherapy Lung Adenocarcinoma Egr1 Promoter Kringle 5 Baculovirus

Higher Vocational and Professional Higher Education Qualifications in the European Level 5 Area——A basis for more international cooperation

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中国高等教育评论 2017年第2期 15-25页

作者： Hans Daale CHAIN5

The'European Level 5 Area'(EL5A)is a relatively new concept for Europe,giving an excellent opportunity to link the sectors for Vocational Education and Training(VET)and Higher Education(HE)to each *** it is about look... 详细信息

关键词： Higher Vocational and Professional Higher Education Qualifications in the European Level 5 Area VET