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Quantitative Determination of Urine Glucose： Combination of Laminar Flow in Microfluidic Chip with SERS Probe Technique

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Chemical Research in Chinese Universities 2018年第6期34卷 899-904页

作者： SUN Dan LIU Xiangyuan XU Shuping TIAN Yu XU Weiqing TAO Yanchun Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical Chemistry Jilin Universiry Changehun 130012 P. R. China

A surface-enhanced Raman scattering（SERS） sensing approach for urine glucose was developed based on the laminar flow technology in a cross-type microfluidic chip with SERS probes, 4-mercaptophenylboronic acid （MPBA） functionalized Ag nanoparticles. MPBA as the glucose receptor can identify and bind up with glucose at a molar ratio of 2：1, which can cause the aggregation of SERS probes at a certain position of the chip channel and further enhance the SERS signal of MPBA significantly. Thus, the quantitative SERS detection of glucose was achieved indirectly. No sample pretreatment and separation were needed in this method since the SERS detection was achieved in the gradient diffusion and molecular recognition processes between urine glucose and SERS probe in the laminar flow, which simplified the sample treahnent procedures, saved detection time and made it feasible for clinic applications. This method shows a good linear relationship within human body＇s normal physiological range and has high sensitivity and selectivity： The lowest detection concentration can reach 1.0 mg/dL.

关键词： Surface-enhanced Raman scattefing(SERS) Microfluidic chip 4-mercaptophenylboronic acid Uurine glucose

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Electrochemical recognition for saccharide by CdSe quantum dots modified boronic acid carrying self-assembled monolayer

Electrochemical recognition for saccharide by CdSe quantum d...

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中国化学会第十五届全国有机分析及生物分析学术研讨会

作者：霍洪玉罗红群李念兵 School of Chemistry and Chemical Engineering Southwest University

In this paper,a novel method for immobilization of boronic acid was constructed by modifying glassy carbon electrode with CdSe quantum dots(QDs) and excellent conductive gold nanoparticles(GNPs) though carbon nanotubes-chitosan(CNTs-CS). The properties of GC/CNTs-CS/QDs/GNPs/BA electrode were characterized by cyclic voltammetry. The pKa values of the BA monolayer before and after combining with sugars were *** fabricated electrode exhibited excellent performances for determining D-glucose,D-galactose and D-fructose on the basis of the change in ip of the Fe(CN) ion in the presence of *** on this,a new biosensor for determining sugars has been developed.

关键词： CdSe quantum dots Gold nanoparticles Carbon nanotubes 4-mercaptophenylboronic acid Sugars

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