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From oral formulations to drug-eluting implants:using 3d and 4d printing to develop drug delivery systems and personalized medicine

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Bio-design and Manufacturing 2022年第1期5卷 85-106页

作者： Niels G.A.Willemen Margaretha A.J.Morsink devin Veerman Classius F.da Silva Juliana C.Cardoso Eliana B.Souto Patrícia Severino Center for Biomedical Engineering Department of MedicineBrigham and Women&HospitalHarvard Medical School65 Landsdowne StreetMA 02139 CambridgeUSA department of developmental BioEngineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Translational Liver Research Department of Medical Cell BioPhysicsTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Targeted Therapeutics Department of Biomaterials Science and TechnologyFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands department of Chemical Engineering Institute of EnvironmentalChemical and Pharmaceutical SciencesFederal University of São PauloRua São Nicolau210Diadema 09913‑030Brazil University of Tiradentes(Unit) and Institute of Technology and Research(ITP)Av.Murilo Dantas300Aracaju 49010‑390Brazil Faculty of Pharmacy University of CoimbraPólo das Ciências da SaúdeAzinhaga de Santa Comba3000‑548 CoimbraPortugal CEB‑Centre of Biological Engineering University of MinhoCampus de Gualtar4710‑057 BragaPortugal Tiradentes Institute 150 Mt Vernon StDorchesterMA 02125USA

Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3d *** using materials that can be tuned upon stimulation,4d printing is *** recent years,many studies have been exploring a new field that combines 3d and 4d printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3d printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3d and 4d printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关键词： drug delivery systems 3d/4d printing drug-eluting implants Microneedles Oral formulations

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3d/4d printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

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International Journal of Extreme Manufacturing 2023年第3期5卷 236-262页

作者： Annan Chen Jin Su Yinjin Li Haibo Zhang Yusheng Shi Chunze Yan Jian Lu State Key Laboratory of Materials Processing and die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministry of EducationWuhan430074People’s Republic of China Centre for Advanced Structural Materials Department of Mechanical EngineeringCity University of Hong KongPeople’s Republic of China Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhen 518057People’s Republic of China CityU-Shenzhen Futian Research Institute Shenzhen 518045People’s Republic of China

Piezoelectricity in native bones has been well recognized as the key factor in bone ***,bio-piezoelectric materials have gained substantial attention in repairing damaged bone by mimicking the tissue’s electrical microenvironment(EM).However,traditional manufacturing strategies still encounter limitations in creating personalized bio-piezoelectric scaffolds,hindering their clinical ***-dimensional(3d)/four-dimensional(4d)printing technology based on the principle of layer-by-layer forming and stacking of discrete materials has demonstrated outstanding advantages in fabricating bio-piezoelectric scaffolds in a more complex-shaped ***,4d printing functionality-shifting bio-piezoelectric scaffolds can provide a time-dependent programmable tissue EM in response to external stimuli for bone *** this review,we first summarize the physicochemical properties of commonly used bio-piezoelectric materials(including polymers,ceramics,and their composites)and representative biological findings for bone ***,we discuss the latest research advances in the 3d printing of bio-piezoelectric scaffolds in terms of feedstock selection,printing process,induction strategies,and potential ***,some related challenges such as feedstock scalability,printing resolution,stress-to-polarization conversion efficiency,and non-invasive induction ability after implantation have been put ***,we highlight the potential of shape/property/functionality-shifting smart 4d bio-piezoelectric scaffolds in bone tissue engineering(BTE).Taken together,this review emphasizes the appealing utility of 3d/4d printed biological piezoelectric scaffolds as next-generation BTE implants.

关键词： 3d/4d printing bio-piezoelectric materials biomimetic scaffolds electrical microenvironment bone regeneration

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3d/4d Printed Functional Continuous Fiber-reinforced Polymer Composites:Progress and Perspectives

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2023年第3期2卷 17-28页

作者： Ping Cheng Shixian Li Yong Peng Antoine Le duigou Kui Wang Said Ahzi Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic&Transportation EngineeringCentral South UniversityChangsha410075China ICube Laboratory-French National Center for Scientific Research University of StrasbourgStrasbourgF-67000France Institute de Research dupty de Lôme Bionics GroupUniversity of South BritanyLorientF-56100France

In recent years,innovations in 3d/4d printing techniques for continuous fiber-reinforced polymer composites(CFRPCs)have opened new perspectives for the integrated design and manufacture of composites with customized *** paper reviews the current state of 3d/4d printed functional composites,including the materi-als,shape memory/changing effects,self-monitoring/healing behaviors,and challenges surrounding additive-manufactured functional ***,continuous fibers and matrices that provide functional roles are classified and discussed in detail.4d printed shape memory and changing CFRPCs can retain their original shapes from a designed shape upon exposure to different external stimuli,including heat,electricity,humidity,and multi-stimuli ***,self-monitoring of structural health is achieved through the piezore-sistive features of reinforced fibers in 3d printed ***,this review concludes with an outlook on the future research opportunities for 3d/4d printed functional CFRPCs.

关键词： 3d/4d printing Continuous fiber Shape memory and changing Self-monitoring Self-healing

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3d/4d printed versatile ﬁbre-based wearables for embroidery, AIE-chemosensing, and unidirectional draining

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Aggregate 2024年第3期5卷 374-383页

作者： Pengchao Liu Chengshengze Chu Wenqi Qiu Lizi Cheng Jialun Gu Zhengyi Mao Zheng Zhao Xinyuan He Guo Liu Chen Peng Kwan Man Ben Zhong Tang Jian Lu department of Mechanical Engineering City University of Hong KongKowloonHong KongChina CityU-Shenzhen Futian Research Institute ShenzhenChina department of Plastic and Aesthetic Center The First Afﬁliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina department of Surgery School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhenChina department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong KongChina department of Radiology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdongChina Laboratory of Nanomaterials and Nanomechanics City University of Hong KongHong KongChina

Fibre-based wearables for embroidery,chemosensing,and bioﬂuid’s unidirectional draining with goodﬂexibility,tunability,and designability drive technological ***,synthetic polymerﬁbres are non-degradable,threatening the environment and human ***,we have developed versatile microﬁbre-based wearables by combining many advantages in one platform of biodegradable polylactic acid(PLA)and melt electrowriting *** potential applications of PLA wearables are achieved byﬂexibly designing their printingﬁles,components and ***-dimensional printingﬁles are generated from two-dimensional images to fabricate‘embroidery-like’***/aggregation-induced emissionﬂuorogens(AIE)chemosensors exhibit colorimetric andﬂuorescent colour changes upon exposure to amine *** PLA-cotton textiles with a hydropho-bic/hydrophilic structure could facilitate unidirectional draining of sweats which is favourable for the management of temperature and humidity on the surface of *** proposed platform can not only broaden the design possibilities in 3d/4d printing but also offer wide potential applications for functional wearables.

关键词： 3d/4d printing aggregation-induced emission chemosensing ﬁbre-based wearable polylactic acid unidirectional draining

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