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vitamin d Insufficiency and Its Association with Biochemical and Anthropometric Variables of Young Children in Rural Southwestern China

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Chinese Medical Journal 2016年第11期129卷 1273-1279页

作者： Shan-Shan Geng Jing-Qiu Ma Shan-Shan Liu Jie Zhang Xiao-Yang Sheng department of Children and Adolescents Health Care Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China MOE-Shanghai Key Laboratory of Children's Environmental Health Shanghai Institute for Pediatric Research Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China department of Anesthesia The Children's Hospital School of Medicine Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Background： With recognition of the important roles of vitamin d （Vitd） in various physiological processes, increasing attention has been drawn to the status of Vitd in early life. However, the Vitd status of young children and the related factors in rural areas of Southwestern China remain unclear. This study aimed to explore Vitd status and its seasonal variation in 18-month-old children living in rural Southwestern China. The association of Vitd with biochemical and anthropometric variables was also investigated. Methods： A total of 177 18-month-old children in a rural area of Yunnan Province, Southwestern China, were enrolled. Serum concentrations of 25-hydroxy vitamin d （25（OH）d） were measured through high-performance liquid chromatogram-tandem mass spectrometry. Parathyroid hormone （PTH） levels were measured with a chemiluminescence assay. Serum concentrations of calcium, phosphorus, and alkaline phosphatase （ALP） were also measured. Anthropometric data and the outdoor activity time of each participant were collected. Results： The serum 25（OH）d concentration was 26.61 ±7.26 ng/ml; concentrations lower than 30 ng/ml accounted for 70.6% of the participants and concentrations lower than 20 ng/ml accounted for 16.4%. The level of serum 25（OH）d was not significantly different among four seasons （P 〉 0.05）. A positive relationship was found between 25（OH）d concentration and the time of outdoor activities （r = 0.168, P 〈 0.05）. Serum PTH concentration was negatively correlated with 25（OH）d concentration （r - 0.163, P 〈 0.05）. A positive relationship was found between the serum concentrations of 25（OH）d and calcium （r = 0.154, P 〈 0.05）. No significant association was observed between 25（OH）d and ALP, phosphorus, or anthropometric variables. Conclusions： The prevalence of Vitd insufficiency is high among young children in the rural Southwestern China regardless of the seasons. Vitd supplementation is still essential to maintain Vitd sufficiency for children living in rural area.

关键词： 25-hydroxy vitamin d Infant Rural Area vitamin d vitamin d deficiency

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Significance of low serum vitamin d for infection risk, disease severity and mortality in critically ill patients

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Chinese Medical Journal 2013年第14期126卷 2725-2730页

作者： SU Long-xiang JIANG Zhao-xu CAO Li-chao XIAO Kun SONG Jia-ping LI Hua ZHANG Xin YAN Peng FENG dan LIU Chang-ting LI Xin XIE Li-xin department of Respiratory Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China Clinical division of Internal Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China department of Medical StatisticsChinese People'sLiberation Army General Hospital Beijing 100853 China Nanlou department of Espiratory diseases Chinese People's Liberation Army General Hospital Beijing 100853 China Medical College of Nankai University Tianjin 300071 China department of Respiratory Medicine Tianjin Chest Hospital Tianjin 300051 China Shenzhen Proteome Engineering Laboratory BGI Shenzhen Shenzhen 518001 China

Background Hospitalized patients often have higher rate of vitamin d deficiency than healthy people. vitamin d levels below normal are associated with hospital stay, increased incidence of adverse prognosis and increased mortality of a number of diseases. Whether there is a relationship between vitamin d levels and infection or sepsis in the critically ill is still unclear. This study will explore the relationship between vitamin d levels and risk of infection, assessment for disease severity, and predictor of mortality. Methods To evaluate the value of vitamin d in intensive care unit （ICU） cases to sepsis, severity and prognosis assessment, high performance liquid chromatography and tandem mass spectrometry were used to measure the concentrations of vitamin d in sera of critically ill patients. The serum samples were drawn within the first 24 hours of ICU admission. Results The study included 206 people, 50 healthy controls, 51 ICU control patients and 105 ICU diagnosed with sepsis. Critically ill ICU patients （ICU sepsis and ICU control group） had lower vitamin d concentration than normal people, but septic patients showed no significant reduction of vitamin d concentration when compared with critically ill patients with no positive etiological evidence. For assessment of disease severity, there were very low negative correlations between APACHE II, SAPS II and SOFA scores and vitamin d level. Additionally, patients of different 25-（OH）d levels showed no difference whether in terms of 28-day survival （χ2=1.78, P=0.776） or 90-day survival （χ2=4.12, P=0.369）. Multivariate Logistic regression demonstrated that APECHE II and SAPS II scores were independent risk factors to deaths caused by sepsis. Conclusion Clinically, serum concentration of vitamin d is not an indicator for diagnosis and assessment in critically ill patients （ClinicalTrial.gov identifier NCT01636232）.

关键词： 25-hydroxy vitamin d infection disease severity mortality critically ill sepsis

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Associations between vitamin d and Type 2 diabetes Mellitus: The Role of vitamin d Receptor and Binding Protein

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Journal of diabetes Mellitus 2020年第4期10卷 222-235页

作者： Eman S. Arafat Inass M. Taha Shahad W. Kattan Nouf Abubakr Babteen Iman Fawzy Medical Biochemistry and Molecular Biology departement Faculty of Medicine Menoufia University Al-Minufya Egypt Medicine department College of Medicine Taibah University Medina KSA Medical Laboratory department College of Applied Medical Science Taibah University Yanbu KSA Biochemistry department Faculty of Science University of Jeddah Jeddah KSA Mansoura Central Laboratories Ministry of Health Mansoura Egypt

Background: Type 2 diabetes mellitus (T2dM) is a chronic disease that is characterized by β-cell dysfunction and resistance for insulin. vitamin d is necessary for insulin secretion so it is a crucial factor in the development of T2dM. This study was done to investigate the association between serum 25-hydroxy vitamin d [25(OH)3d], VdR (vitamin d receptor) and VdBP (vitamin d binding protein) with type 2 diabetic patients compared to control subjects. Subjects and Methods: This study carried out 110 female patients who were previously diagnosed with type 2 diabetes and 110 age, sex and weight matched as controls. All participants were subjected to full history taking, clinical examination and assessment of fasting blood glucose, HbA1c , lipid profile, 25-hydroxy vitamin d [25(OH)3d], VdR and VdBP. Results: Results showed that the level of 25(OH)3d was significantly lower in diabetic group compared to controls and was significantly negatively correlated with glycated hemoglobin, serum total cholesterol and low density lipoprotein cholesterol in type 2 dM. decreasing vitamin d level was significantly associated with decreasing VdR. No significant association was found between Vit d and VdBP levels. Conclusions: vitamin d deficiency is frequent in diabetic patients and associated with poor control and outcome. This suggests a role of vitamin d in the pathogenesis and control of T2dM. Serum VdBP in diabetes may be independent to the level of 25(OH)3d and needs further studies.

关键词： diabetes Mellitus Type 2 25-hydroxy vitamin d vitamin d Receptor vitamin d Binding Protein

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The monitoring and diagnostic value of serum bone metabolic markers in type 2 diabetes mellitus complicated with retinopathy

The monitoring and diagnostic value of serum bone metabolic ...

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第十三届全国免疫学学术大会

作者： Liming Tan Xiaolin Guan Li Shi Tingting Long Qiaohua Wang Yimei Meng Wei Zheng the Second Affiliated Hospital of Nanchang University College of public health Nanchang University department of clinical laboratory Jiangxi children's Hospital

Objective: To investigate the clinical value of serum 25-hydroxyvitamin d [25-(OH)d], bone alkaline phosphatase(BALP), osteocalcin(OC), and parathyroid hormone(PTH) levels in diagnosis and monitoring type 2 diabetes mellitus(T2dM) complicated with retinopathy(dR).Methods: Select 714 cases of type 2 diabetic retinopathy(T2dM-dR) patients, 139 cases of non T2dM-dR patients and 52 normal controls from the Second Affiliated Hospital of Nanchang University, and detect 25-(OH) d, BALP, OC, PTH using electrochemical luminescence method(ECLIA), and detect glycosylated hemoglobin(HbA1c-2) by ion exchange high pressure liquid chromatography method(HPLC), finally compare and analysis results.Results:(1) the indexes of bone metabolism and HbA1c-2 of in the T2dM-dR group were different from those of the normal control group, and all had very statistical significance(P25-(OH) d, BALP, OC, and PTH’ in T2dM-dR group had significant statistical significance when compared with the normal control group(Pd that 25-(OH) d and OC were the protective factors of T2dM complicated dR, and BALP and PTH were risk factors, and all the four indicators are closely related to the occurrence of T2dM complicated dR;(4) area under the ROC curve(AUC) of 25-(OH)d, OC, and HbA1c-2 were 0.803, 0.829, 0.977, Pdiagnostic accuracy to T2dM-dR was high.Conclusion: the abnormal detection results of bone metabolism indicators have good predictive and warning significance in T2dM patients complicated with dR.

关键词： type 2 diabetic retinopathy 25-hydroxy vitamin d bone alkaline phosphatase osteocalcin

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