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Transduction Pathway to Sense the Attractive Signal Molecule 2-heptanone in Caenorhabditis elegans

Transduction Pathway to Sense the Attractive Signal Molecule...

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Chunmei Zhang Jinyuan Yan Wei Zou Yao Chen Xiaowei Huang Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University Yunnan University

Caenorhabditis elegans live in the soil, a complex environment. They has developed astructure-simple but fully functional system of neurons,which make them become amodel organism for studying the development of neurons system and the related behaviors.C. elegans can employ chemosensory neurons to detect a wide range of environmentalfactors that are commonly associated with the food or dangerous clues, distinguish thesurroundings, and finally change their behaviors, such as chemotaxis, aversion or someother stress behaviors, to response the *** is one of the most versatile and sensitive strategies to seek food and avoiddanger by sensing volatile chemicals. The recent researches have suggested that somepathogenic microorganisms, including the pathogenic bacteria Pseudomonas aeruginosaand Serratia marcescens, can attract nematodes via producing the attractive volatile chemicalsas the signals. But how the worms mistake the perception of compounds as well asthe underlying molecular mechanism remains unknown. Therefore, our current studyshowed that the pathogenic bacteria *** B16 can at least secrete three volatilechemicals, benzaldehyde, 2-heptanone and 2-ethyl alcohol, which have the remarkableabilities to lure C. elegans. Among the attractive signals, benzaldehyde and 2-heptanonewere detected by AWC olfactory neurons, and 2-ethyl alcohol was detected by AWA olfactoryneurons. Furthermore, chemotaxis assay was used to identify the response ofmutants to 2-heptanone. It was found that the worms with the str-2 gene mutation weredefective in their response to 2-heptanone, but exhibited wild-type behavior in their responsesto benzadelhyde and 2-ethyl alcohol. After str-2 was expressed in mammaliancells HEK293 T, assay of the Ca2+ revealed that the receptor STR-2 mediated the elevationof Ca2+ in response to 2-heptanone, implying STR-2 is the candidate receptor of 2-heptanone. Additionally, we tried to determine the other components in the signal tra

关键词： 2-heptanone Caenorhabditis elegans chemosensory neurons

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