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Chromosome 1p/19q status combined with expression of protein improves the diagnostic and prognostic evaluation of oligodendrogliomas

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Chinese Medical Journal 2010年第24期123卷 3566-3573页

作者： XIONG Ji LIU Ying WANG Yin KE Rong-hu MAO Ying YE Zhu-rong Department of Neuropathology Institute of Neurology Huashan Hospital of Fudan University Shanghai 200040 China Department of pathology Shanghai Medical College of Fudan University Shanghai 200032 China Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China

Background Our previous study confirmed that oligodendrogliomas had higher frequency of chromosome 1p/19q deletion. In order to improve the diagnostic criteria and to predict the prognosis of oligodendroglioma patients, the status of chromosome 1 p/19q deletion, the methylation of O6-methylguanine-DNA methyltransferase （MGMT）, and the expression of p53 protein were evaluated and investigated in relation to patients＇ *** Methylation of MGMT in 73 cases was analyzed by nested methylation-specific pCR （MSp）. The levels of MGMT and p53 protein were tested with immunohistochemistry. pearson＇s chi-square test and Fisher＇s exact test were used. Multivariate and Kaplan-Meier analysis were performed to determine patients＇ *** Both oligodendrogliomas and astrocytic gliomas exhibited frequent methylation of MGMT. However, the results of MSp did not completely correspond to that of the immunohistochemical staining for MGMT. The expression of p53 protein was more frequently observed in patients without a 1 p or 19q deletion in anaplastic oligodendrogliomas （=0.032,0.025）. In low-grade oligodendrogliomas, methylation of MGMT was more frequent in patients with 1 p/19q deletion than in patients with 1p/19q intact （p=0.038）. patients with oligodendrogliomas with 1p/19q loss of heterozygosity and p53-negative showed a longer progression-free *** Detection of chromosome 1p/19q status combined with p53 protein immunohistochemistry might be beneficial to improve the pathological diagnosis and to determine the prognosis of patients with oligodendrogliomas.

关键词： astrocytic glioma O6-methylguanine-DNA methyltransferase oligodendroglioma p53 protein 1p/19q deletion

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