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Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21

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Chinese Journal of Cancer 2016年第4期35卷 171-180页

作者： Jiang-Yong Yu Si-Fan Yu Shu-Hang Wang Hua Bai Jun Zhao Tong-Tong An Jian-Chun Duan Jie Wang The Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Thoracic Medical Oncology Peking University School of OncologyBeijing Cancer Hospitaland Institute

Background:Epidermal growth factor receptor(EGFR) mutations,including a known exon 19 deletion(19 del) and exon 21 L858 R point mutation(L858R mutation),are strong predictors of the response to EGFR tyrosine kinase inhibitor(EGFR-TKI) treatment in lung ***,whether patients carrying EGFR 19 del and L858 R mutations exhibit different responsiveness to EGFR-TKls and what are the potential mechanism for this difference remain *** study aimed to investigate the clinical outcomes of EGFR-TKI treatment in patients with EGFR 19 del and L858 R mutations and explore the genetic heterogeneity of tumors with the two mutation ***:Of 1127 patients with advanced lung adenocarcinoma harboring EGFR 19 del or L858 R mutations,532 received EGFR-TKI treatment and were included in this *** 19 del and L858 R mutations were detected by using denaturing high-performance liquid chromatography(DHPLC).T790 M mutation,which is a common resistant mutation on exon 20 of EGFR,was detected by amplification refractory mutation system(ARMS).Next-generation sequencing(NGS) was used to explore the genetic heterogeneity of tumors with EGFR 19 del and L858 R ***:Of the 532 patients,319(60.0%) had EGFR 19 del,and 213(40.0%) had L858 R *** patients with EGFR 19 del presented a significantly higher overall response rate(ORR) for EGFR-TKI treatment(55.2%vs.43.7%,P = 0.017) and had a longer progression-free survival(PFS) after first-line EGFR-TKI treatment(14.4 vs.11.4 months,P = 0.034) compared with those with L858 R ***,no statistically significant difference in overall survival(OS) was observed between the two groups of patients.T790 M mutation status was analyzed in 88 patients before EGFR-TKI treatment and 134 after EGFR-TKI treatment,and there was no significant difference in the co-existence of T790 M mutation with EGFR 19 del and L858 R mutations before EGFR-TKI treatment(5.6%vs.8.8%,P = 0.554)or after treatme

关键词： EGFR exon 19 deletion EGFR exon 21 L858R point mutation Lung adenocarcinoma Treatment efficacy

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Ganotherapy and Holistic Human System Is the Pathway of Holistic Health for Immediate Relief for COVID19

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Open Journal of Preventive Medicine 2020年第3期10卷 45-61页

作者： Sivakumaran Karuppiah Lim Siow Ji Department of Research and Development of Natural Medicine DXN Pharmaceutical Sdn. Bhd. Kulim Malaysia Association of Iridolology Practitioners Malaysia (IRHOL) Selangor Malaysia Association of Ganotherapy Practitioners Malaysia (GANOHM) Selangor Malaysia.

This research of study continues personal research and professional practice in the Alternative Medicine (AM) has become an attractive and a popular issue between academicians and researchers in the last decades. AM is mostly used by individuals to support or to substitute the medical treatment. The studies from different disciplines have shown that the AM use is expanding all over the world but the popularity and the types of its use remain unclear. A qualitative study was conducted by treating a patient through several kinds of AM, receiving positive feedback from the patient. The overall data shows very good improvement since the AM becomes one of their parts of life to continue surviving on this earth with lots of challenges. Herbalist and vitamin supplements are the most popular and commonly used alternative medicine methods. Most people had used alternative medicine to improve their health conditions, thus eliminating the side effects of modern treatments. To supersede and recover or heal this chronic symptom, a combination of AM will be great to encounter it such as cancer, psoriasis, epilepsy, viral fever, etc. A combination of Ganotherapy and Knowledge of Holistic Human System enhances the AM era into battling these chronic cases and creates a powerful immune system to protect against it.

关键词： Ganotherapy Holistic Human System Covid 19 Viral

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COVID 19 Diagnostic Tests: A Study of 12,270 Patients to Determine Which Test Offers the Most Beneficial Results

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Surgical Science 2020年第4期11卷 82-88页

作者： Ali Mahmood Charisma Gajula Prianka Gajula Houston Methodist Specialty Group Methodist Sugar Land Colon & Rectal Surgery Sugar Land TX USA Institute of Academic Medicine Houston Methodist Hospitals System Houston TX USA Michael E. DeBakey Department of Surgery Baylor College of Medicine Houston TX USA Department of Surgery College of Medicine Texas A&M Health Science Center Houston Methodist Campus Houston TX USA Department of Surgery Weill Cornell Medical College New York NY USA Department of Colon & Rectal Surgery Houston Methodist Hospitals System Sugar Land TX USA Baylor University Waco TX USA Department of Medicine Houston Methodist Hospitals System Houston TX USA.

COVID 19 has caused capitulation from healthcare entities all over the world. First described in Hubei, China, the virus has spread to 185 countries, showing little signs of eradication or eradication. There does not exist a medical treatment regimen or a vaccine to address COVID 19 definitively. The best response, to date, has been early diagnosis and immediate isolation or quarantine of the patient, with supportive care. As medical institutions all around the world struggle to keep up with this pandemic, there is not a consensus amongst medical professionals in the rapid diagnosis of this disease entity. Purpose: The purpose of our study was to review the literature and establish a test, or tests, that would aid the clinician in attaining a swift, yet accurate diagnosis. Methods: We searched PubMed and Google scholar and reviewed 32 articles. Keyword searches consisted of COVID 19, pandemic, diagnoses, diagnostic testing, pandemic amongst others. We compared the data obtained from these studies in an effort to find the best diagnostic test. Results: There were a total of 12,270 patients that were in our study [1]-[32]. This is the largest study to date in the literature addressing diagnosis of COVID 19. Fever, cough and fatigue, in that respective order were the most common clinical symptoms. Laboratory findings consisted of leukopenia, elevated erythrocyte sedimentation (ESR) and elevated C-reactive protein, CRP. The gold standard test described in multiple studies was the RT-PCR. Serum assays of IgM and IgG were also drawn and found to be accurate in 93% of the time. CT Chest was both sensitive and specific, 90% and 86%. This diagnostic imaging was even more successful when coupled with clinical symptoms and approaching days 7 - 12 since the onset of clinical symptoms. Discussion: This is the largest study compiled to address diagnostic testing in COVID 19 patients. The patient population is spread vastly around the world, with access to many reported tests limi

关键词： COVID 19 Diagnostic Test RT-PCR IgM-IgG Chest CT Pandemic

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The 19 kDa Protein from <i>Mycobacterium avium subspecies paratuberculosis</i>Is a Glycolipoprotein

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Advances in Microbiology 2013年第7期3卷 520-528页

作者： Saleh A. Naser Saisathya Thanigachalam Natalia Spinelli Mitra M. Safavi Najih Naser Omar Khan BioSynse Cary US Burnett School of Biomedical Sciences College of Medicine University of Central Florida Orlando USA

This study characterizes the 19 kDa protein expressed by Mycobacterium avium subspecies paratuberculosis (MAP) as a glycolipoprotein, providing the foundation for future experiments regarding its antigenicity and role in disease pathogenicity. We have previously shown that a 4.8 kb insert from MAP will produce a 16 kDa recombinant protein when expressed in Escherichia coli and 19 kDa recombinant protein when expressed in M. smegmatis (smeg19K). The difference of 3 kDa in size of these expressed proteins may be related to post translational modifications that occur in Mycobacterium species. We hypothesized that smeg19K is a glycolipoprotein since BLAST analysis revealed approximately 76% amino acid identity between the MAP 19 kDa protein and a known lipoglycoprotein, the 19 kDa protein of M. tuberculosis. This prediction was confirmed by the following positive staining of smeg19K with Sudan Black 4B, a postelectrophoresis dye used to stain for lipids. Smeg19K has also stained positively for glycosylation with the lectin concavalin A, a highly specific stain for mannose residues. As expected, treatment with tunicamycin (an antibiotic known to inhibit N-glycosylation) and treatment with deglycosylation assay (non-specific for mannose), showed no reduction in size of 19 kDa glycolipoprotein.

关键词： Mycobacterium Avium Subspecies Paratuberculosis Glycolipoprotein 19 KDa Protein Post Translational Modification

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19世纪末至20世纪初西方音乐伦理的精神意蕴

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2013年

作者：凌宪初

本书主要内容包括：浪漫主义时期音乐伦理观的嬗变；世纪末音乐家作品中的伦理呈现；现代性极端发展的新世纪音乐伦理；20世纪表现主义音乐中的伦理体现。

ISBN: (纸本)9787564806958

关键词：西洋音乐伦理学 19 20世纪

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地芝丸对D-半乳糖衰老小鼠表皮角蛋白K19、水通道蛋白AQP3及皮肤组织形态学结构的影响研究

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中药药理与临床 2019年第3期35卷 41-45页

作者：刘晶唐昌敏孙晶晶王莉陈刚湖北中医药大学武汉430061 湖北中医药高等专科学校荆州434020

目的:观察地芝丸对D-半乳糖衰老小鼠水通道蛋白AQP3、角蛋白K19、以及皮肤组织形态学结构的影响,探讨地芝丸延缓皮肤衰老的作用机制。方法:以D-半乳糖衰老小鼠为研究对象,测定超氧化物歧化酶(SOD)、丙二醛(MDA)的含量,以及HE染色法观察... 详细信息

目的:观察地芝丸对D-半乳糖衰老小鼠水通道蛋白AQP3、角蛋白K19、以及皮肤组织形态学结构的影响,探讨地芝丸延缓皮肤衰老的作用机制。方法:以D-半乳糖衰老小鼠为研究对象,测定超氧化物歧化酶(SOD)、丙二醛(MDA)的含量,以及HE染色法观察各组小鼠皮肤组织形态学结构改变。应用酶联免疫吸附法(ELISA)检测小鼠皮肤AQP3的含量,免疫荧光法检测表皮角蛋白K19的表达。结果:与空白对照组比较,模型组皮肤表皮层和真皮层明显变薄;SOD、AQP3含量降低、K19表达下调、MDA含量升高。与模型组相比较,地芝丸剂量依赖地使SOD、AQP3明显增高,MDA降低,使VE组、地芝丸各组小鼠皮肤组织形态学结构有所改善,表皮层和真皮层厚度增厚,K19表达上调,尤以27.3 g/kg组最显著。结论:地芝丸通过改善皮肤组织形态学结构,促进D-半乳糖衰老小鼠表皮AQP3、K19的表达,起到延缓皮肤衰老作用。

关键词：地芝丸水通道蛋白AQP3 角蛋白K 19 皮肤组织形态学结构

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Diagnostic Value of CYFRA21-1, CA19-9 and SCCAg Detection in Esophageal Cancer

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Proceedings of Anticancer Research 2018年第2期2卷 4-7页

作者： Du Chunran Wang Yanming Hou Shenyan Clinical Laboratory Central Hospital of Liaoning ProvinceChaoyang 122000LiaoningChina

Objectives To investigate the value of serum cytokeratin 19 fragment(CYFRA21-1),carbohydrate anti-gen 19-9(CA19-9)and squamous cell carcinoma antigen(SCCAg)in the diagnosis of esophageal *** 100 cases of esophageal cancer(study group)and 50 healthy subjects(control group)were recruited in the study,the serum levels of CYFRA21-1,CA19-9 and SCCAg in these patients were *** analysis was performed in study group by clinical staging,and the diagnostic value of CYFRA21-1,CA19-9 and SCCAg in detecting esophageal cancer was analyzed by receiver operating characteristic curve(ROC).Results The serum levels of CYFRA21-1,CA19-9 and SCCAg in study group were significantly higher than those in control group,and those were significantly lower in patients with stageⅠ-Ⅱdisease than those with stageⅢandⅣdisease,indicating statistically significant difference(P19-9 and SCCAg in the diagnosis of esophageal cancer was 82.26%,and specificity was 91.33%,with positive predictive value being 86.14%,and negative predictive value being 89.57%,and AUC value was 0.864,the combined detection was superior to each measure utilized alone,the difference was significantly significant(P19-9,and SCCAg can significantly improve the diagnostic sensitivity and specificity in detecting the esophageal cancer.

关键词： cytokeratin 19 fragment carbohydrate antigen 19-9 squamous cell carcinoma antigen esophageal cancer

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19ku脂蛋白信号肽优化表达的牛病毒性腹泻病毒E2基因重组卡介苗初步免疫研究

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中国预防兽医学报 2015年第12期37卷 962-965页

作者：时坤孙凡婷张妍李晶刘菲刘杨杜锐吉林农业大学中药材学院/教育部动物生产及产品质量安全重点实验室/吉林省药用动物二级实验室吉林长春130118 吉林农业大学动物科学技术学院吉林长春130118

为评价19ku脂蛋白信号肽优化表达的牛病毒性腹泻病毒(BVDV)重组卡介苗对小鼠的免疫效果,本研究将已构建的rBCG/19ku-E_2、rBCG/E_2、rBCG/pMV261(pMV261空载体构建的rBCG作为实验对照组)、卡介苗(BCG)及BVDV灭活苗免疫小鼠,通过检测血... 详细信息

为评价19ku脂蛋白信号肽优化表达的牛病毒性腹泻病毒(BVDV)重组卡介苗对小鼠的免疫效果,本研究将已构建的rBCG/19ku-E_2、rBCG/E_2、rBCG/pMV261(pMV261空载体构建的rBCG作为实验对照组)、卡介苗(BCG)及BVDV灭活苗免疫小鼠,通过检测血清抗体效价、T淋巴细胞亚群含量及细胞因子水平,评价其体液免疫与细胞免疫效果。结果显示,rBCG/19ku-E_2可以引起BVDV特异性抗体的产生,并且抗体水平要高于rBCG/E_2、rBCG/pMV261组。对CD4^+、CD8^+T淋巴细胞亚群含量的检测结果表明,rBCG免疫小鼠对CD4^+、CD8^+T淋巴细胞亚群没有显著影响。通过对IL-4、IL-10、IL-12和IFN-γ细胞因子检测结果表明,rBCG主要诱导Th1型细胞免疫应答,rBCG/19ku-E_2诱导的细胞因子水平低于BCG免疫组,但均高于细胞因子的平均水平。结果表明,rBCG/19ku-E_2可以诱导小鼠产生较好的特异性体液免疫应答和细胞免疫应答,为BVDV新型疫苗研究奠定基础。

关键词：牛病毒性腹泻病毒 19 ku脂蛋白信号肽重组卡介苗免疫

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The Role of Serum Cytokeratin 19 Fragment in Transarterial Infusion against Invasive Bladder Cancer

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Open Journal of Urology 2013年第3期3卷 160-164页

作者： Ryo Takahashi Ryoji Kimata Shunichiro Nomura Ichiro Matsuzawa Yasutomo Suzuki Tsutomu Hamasaki Yukihiro Kondo Department of Urology Nippon Medical School Tokyo Japan

Background: We used transcatheter arterial infusion chemotherapy (TAI) for patients with T1G3 and greater than T2 bladder cancer, which was diagnosed after extensive and deep transurethral resection of bladder tumor (TUR-BT), and we investigated the utility of serum cytokeratin 19 fragment (CYFRA) as a predictive factor of the response to therapy. Material and Methods: From November 2001 to November 2010, 56 patients (46 males and 10 females) with pathologically confirmed T1 G3 or greater than T2 bladder cancer after TUR-BT underwent two courses of TAI of cisplatin, methotrexate and doxorubicin as neoadjuvant setting. Then, patients underwent evaluation TUR-BT. Thereafter, the bladder was preserved in patients with superficial or undetectable tumors on TUR-BT. Advanced cases and residual bladder tumor cases were treated with total cystectomy or systemic chemotherapy. CYFRA levels were measured before and after performing TAI. Results: With this therapy, the 5-year survival rate was 85.7% in pT1G3, 82.3% in pT2, and 66.6% in greater than pT3 cases. Bladder preservation with no recurrence was observed in 58.7% of the patients. Grade III adverse events included leucopenia (6/56 patients: 10.7%). Serum CYFRA levels significantly decreased with treatment (in 4/6 patients with elevated CYFRA levels). Conclusion: These results suggest that although total cystictomy is usually indicated for T1G3 bladder cancers, bladder preservation and control of micrometastases can be achieved by performing TAI after extensive and deep TUR-BT. Our results also suggest the utility of monitoring serum CYFRA to assess the response to therapy.

关键词： Transcatheter Arterial Infusion (TAI) Invasive Bladder Cancer Cytokeratin 19 Fragment (CYFRA)

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Expression of Med 19 Protein in Tongue Cancer and Its Significance

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Medicinal Plant 2017年第2期8卷 54-56页

作者： Xuyang LIU Lingling LI Shengzhi WANG Department of Oral and Maxillofacial Surgery The Affiliated Yantai Yuhuangding Hospital of Qingdao University

[Objectives] To study the expression of Med 19 protein in tongue cancer and its significance. [Methods] Immunohistochemical method was used to detect the expression of Med 19 protein in tongue cancer tissue and paracancerous tissue. [Results]The expression of Med19 protein in tongue cancer tissue was higher than paracancerous tissue and normal tissue. The expression of Med 19 protein was related to the tumor lymph node metastasis. However,there was no significant difference in sex,age,Tumor Node Metastasis( TNM),and differentiation degree. [Conclusions] Med 19 protein participates in incidence and development of tongue cancer and may become diagnostic indicator and therapeutic target for tongue cancer.

关键词： Med 19 protein Tongue cancer Immunohistochemistry

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