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lambda-cyhalothrin disrupts the up-regulation effect of 17β-estradiol on post-synaptic density 95 protein expression via estrogen receptor α-dependent akt pathway

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Journal of Environmental Sciences 2016年第3期28卷 252-260页

作者： Qunan Wang Xin Xia Xiaomei Deng Nian Li Daji Wu Long Zhang Chengwei Yang Fangbiao Tao Jiangning Zhou Chinese Academy of Science Key Laboratory of Brain Function and Diseases School of Life SciencesUniversity of Science and Technology of China Department of Toxicology College of Public HealthAnhui Medical University Department of Pharmacy Affiliated Anhui Provincial HospitalAnhui Medical University Department of Maternal and Child health College of Public HealthAnhui Medical University

lambda-cyhalothrin（LCT）,one of the type II pyrethroids,has been widely used throughout the *** estrogenic effect of LCT to increase cell proliferation has been well ***,whether the estrogenic effect of LCT will influence neurodevelopment has not been *** addition,17β-estradiol（E2）plays a crucial role in neurodevelopment and induces an increase in synaptic *** post-synaptic density 95（PSD95）protein,which is involved in the development of the structure and function of new spines and localized with estrogen receptor α（ERα）at the post-synaptic density（PSD）,was detected in our study by using hippocampal neuron cell line *** found that LCT up-regulated PSD95 and ERα expression,estrogen receptor（ER）antagonist ICI182,780 and phosphatidylinositol-4;5-bisphosphate 3-kinase（PI3K）inhibitor LY294,002 blocked this *** addition,LCT disrupted the promotion effect of E2 on *** investigate whether the observed changes are caused by ERα-dependent signaling activation,we next detected the effects of LCT on the ERα-mediated PI3K-Protein kinase B（PKB/akt）-eukaryotic initiation factor（e IF）4E-binding protein 1（4E-BP1）*** existed an activation of akt and the downstream factor 4E-BP1 after LCT *** addition,LCT could disrupt the activation effect of E2 on the akt ***,no changes in c AMP response element-binding protein（CREB）activation and PSD95 messenger ribonucleic acid（m RNA）were *** findings demonstrated that LCT could increase the PSD95 protein level via the ERα-dependent akt pathway,and LCT might disrupt the up-regulation effect of E2 on PSD95 protein expression via this signaling pathway.

关键词： 17β-estradiol akt pathway interference lambda-cyhalothrin post-synaptic density 95

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