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Herbal formula BaWeiBaiDusan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

引用

Acta Pharmaceutica sinica B 2023年第8期13卷 1164-1179页

作者： Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyTaipaMacao 999078China Beijing University of Chinese Medicine Beijing 100029China Cancer Center Faculty of Health Science、MOE Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China state Key Laboratory of Dampness syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120China

sepsis-induced liver injury(sILI)is an important cause of septicemia ***(BWBDs)was extracted from a formula of Panax ginseng ***,Lilium brownie *** ex Miellez *** Baker,Polygonatum sibiricum *** Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)***.,and Cortex ***,we investigated whether the BWBDs treatment could reverse sILI by the mechanism of modulating gut *** protected mice against sILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal *** selectively promoted the growth of Lactobacillus johnsonii(***)in cecal ligation and puncture treated *** microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDs anti-sepsis ***,*** significantly reduced sILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal ***,heat inactivation ***(***)treatment promoted macrophage anti-inflammatory activity and alleviated *** findings revealed BWBDs and gut microbiota *** as novel prebiotic and probiotic that may be used to treat *** potential underlying mechanism was at least in part,via ***-dependent immune regulation and interleukin-10+M2 macrophage production.

关键词： BaWeiBaiDusan sepsis-induced liver injury Network pharmacology 16s pacbio smrt sequencing Lactobacillus johnsonii Macrophages Interleukin-10

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