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Evaluating the influence of 6 mv and 15 mv photon beams on prostate intensity-modulated radiation therapy plans

Oncology and Translational Medicine 2016年第1期2卷 26-33页

作者： Reham A.El Gendy Ehab M.Attalla Yasser M.Elkerm Ali Alfarrash Ayadi Al Mostakbl 0ncology Center AlexandriaEgypt National Cancer Institute Cairo UniversityCairoEgypt Cancer Management and Research Department Medical Research InstituteAlexandria UniversityAlexandriaEgypt Faculty of Science Mansoura UniversityMansouraEgypt

Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy （IMRT） photon beams on the target volume planning and on the critical organs in the case of prostate can-cer. Methods Thirty plans were generated by using either 6 mv or 15 mv beams separately, and a combination of both 6 and 15 mv beams. Al plans were generated by using suitable planning objectives and dose con-straints, which were identical across the plans, except the beam energy. The plans were analyzed in terms of their target coverage, conformity, and homogeneity, regardless of the beam energy. Results The mean percentage values of V70 Gy for the rectal wal for the plans with 6 mv, 15 mv, and mixed-energy beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were 53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 mv, 15 mv, and mixed-en-ergy plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 mv plans was 10% larger than those for the 15 mv and mixed-energy *** These preliminary results suggest that mixed-energy IMRT plans may be advantageous with respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the organs at risk may not be clinical y relevant, in this study, IMRT plans using mixed-energy beams exhibited better OAR sparing and overal higher plan quality for deep-seated tumors.

关键词： intensity-modulated radiation therapy (IMRT) mixed-energy plans 6 mv 15 mv prostate cancer radiation treatment planning dose-volumetric analysis

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