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EVAPORATION BEHAVIOR OF COMPONENTS IN Ti-15-3 MELT DURING ISM PROCESS

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中国有色金属学会会刊：英文版 1998年第4期8卷 8-12页

作者： Guo, Jingjie Liu, Yuan Su, Yanqing Ding, Hongsheng Jia, Jun Harbin Inst of Technology Harbin China

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关键词： Ti 15 3 alloy evaporation loss ISM process

Skull formation and change during ISM process of Ti-15-3 alloy

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中国有色金属学会会刊：英文版 2000年第1期10卷 14-18页

作者：郭景杰刘源苏彦庆丁宏升贾均 Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

The change of the skull shape and size has been predicated through computer simulation technique and compared with the experimental results. The microstructure of the skull and the elemental line distribution in the skull have been analyzed with optical microscope and EPMA etc. The results show that the skull height and thickness become small with increasing melting power; the skull consists of two zones, that is, fine equiaxial crystal zone and coarse columnar crystal zone; there exists some segregation in the bottom of the skull.

关键词： Ti 15 3 alloy skull melting microstructure segregation

OPTIMIZATION OF PROCESSING PARAMETERS DURING ISM PROCESS OF Ti-15-3

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中国有色金属学会会刊：英文版 1999年第1期9卷 19-21,21+23+20+22页

作者： Guo, Jingjie Su, Yanqing Liu, Yuan Ren, Zhijiang Jia, Jun Harbin Inst of Technology Harbin China

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关键词： induction skull melting Ti 15 3 optimization of processing parameters

Synthesis of 5,10,15,20-Tetra[4-（N-ethylpiperazinyl）phenyl]-porphyrin and Its Interaction with DNA

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Chinese Journal of Chemistry 2005年第4期23卷 431-436页

作者：郭灿城李和平张晓兵 CollegeofChemistryandChemicalEngineering HunanUniversityChangshaHunan410082China DepartmentofChemistry ChangshaUniversityofScienceandTechnologyChangshaHunan410077China

Piperazinyl-porphyrin, 5,10,15,20-tetra[4-(N-ethylpiperazinyl)phenyl]porphyrin (TEPPH2), was synthesized based on the special affinity of porphyrin to cancer cells and the antitumor activity of piperazine compounds. Its structure was characterized by UV-vis and 1H NMR spectra and elemental analysis. A model for the interaction between TEPPH2 and calf thymus DNA was built, and the binding mechanism was investigated by UV-vis and fluorescence spectra. The results indicated that TEPPH2 could intercalate into the base pairs of DNA strongly. One calf thymus DNA molecule could bind 88 TEPPH2 molecules, and the binding constant K is 8.4×106 L·mol-1. The binding number and binding constant of TEPPH2 with DNA are higher than those of the known anti-tumor drugs, tetrakis(4-N-methylpyridyl)porphine and the Schiff bases Ca/sal-his and Ni/sal-aln.

关键词： 5 10 15 20-tetra[4-(N-ethylpiperazinyl)phenyl]porphyrin calf thymus DNA synthesis fluorescence spectrum UV-vis spectrum

HILBERT PROBLEM 15 AND NONSTANDARD ANALYSIS(Ⅰ)

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Acta Mathematica Scientia 2020年第1期40卷 1-15页

作者： Banghe LJ KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

Hilbert problem 15 required understanding Schubert's *** this book,reducing to degenerate cases was one of the main methods for *** found that nonstandard analysis is a suitable tool for making rigorous of Schubert's proofs of some results,which used degeneration method,but are obviously not *** this paper,we give a rigorous proof for Example 4 in Schubert's book,Chapter 1.§4 according to his *** shows that Schubert's intuitive idea is correct,but to make it rigorous a lot of work should be done.

关键词： Hilbert problem 15 nonstandard analysis enumeration geometry

Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort

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World Journal of Gastroenterology 2020年第14期26卷 1660-1673页

作者： Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita Department of Gastroenterology St Vincent’s HospitalSydney 2010Australia St Vincent’s Clinical School Faculty of MedicineUniversity of New South WalesSydney 2010Australia

BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late ***,biomarkers have limited use in early diagnosis of *** inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other *** To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening *** A feasibility prospective single centre cohort study was *** recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen *** were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic ***-1/GDF15 serum levels were quantified using *** in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed *** One hundred twenty participants were prospectively recruited from ***-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal *** serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Seria

关键词： Growth differentiation factor 15 Cytokines Pancreatic neoplasms Digestive system neoplasms Pancreatic diseases Biomarkers Diagnostic screening programs

Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

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World Journal of Gastroenterology 2019年第38期25卷 5850-5861页

作者： Xia Zhu Kang Chao Miao Li Wen Xie Hong Zheng Jin-Xin Zhang Pin-Jin Hu Min Huang Xiang Gao Xue-Ding Wang Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Gastroenterology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States School of Public Health Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian *** nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this *** potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been *** we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C *** Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February ***15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were *** A total of 411 Crohn’s disease patients were *** was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 *** CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 *** 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,*** The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C *** 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.

关键词： Crohn’s disease Thioguanine nucleotide levels Nucleoside diphosphatelinked moiety X-type motif 15 Thiopurine-induced leukopenia

Effects of hepatitis E virus infection on interferon production via ISG15

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World Journal of Gastroenterology 2018年第20期24卷 2173-2180页

作者： Min Wang Ying Huang Man He Wen-Ju Peng De-Ying Tian Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510700Guangdong ProvinceChina

AIM To assess the effects of hepatitis E virus(HEV) on the production of type Ⅰ interferons(IFNs) and determine the underlying *** We measured the production of interferon(IFN)-alpha and-beta(-α/β) in genotype 3 HEV-infected C3 A cells at different time points(0, 8, 12, 24, 48, 72 and 120 h) by enzyme-linked immunosorbent assay(ELISA). The expression levels of IFN-stimulated gene(ISG)15 in HEVinfected C3A cells at different time points were tested by western blotting. The plasmid-expressing open reading frame 3(ORF3) or control plasmids(green fluorescent protein-expressing) were transfected into C3A cells, and the levels of IFN-α/β and ISG15 were evaluated, respectively. Furthermore, the plasmid-expressing ISG15 or small interfering RNA-inhibiting ISG15 was transfected into infected C3A cells. Then, the production of IFN-α/β was also measured by *** We showed that genotype 3 HEV could enhance the production of IFN-α/β and induce elevation of ISG15 in C3A cells. HEV ORF3 protein could enhance the production of IFN-α/β and the expression of ISG15. Additionally, ISG15 silencing enhanced the production of IFN-α/β. Overexpression of ISG15 resulted in the reduction of IFN-α/β.CONCLUSION HEV may promote production of IFN-α/β and expression of ISG15 via ORF3 in the early stages, and increased ISG15 subsequently inhibited the production of IFN-α/β.

关键词： open reading frame 3 interferon-stimulated gene 15 interferon-alpha Hepatitis E virus interferonbeta

Bone Morphogenetic Protein 15 as a Candidate Gene for Prolificacy of Jining Grey Goat

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畜牧兽医学报 2009年第S1期40卷 1-7页

作者： FENG Tao ZHAO You-zhang CHU Ming-xing DI Ran ZHANG Ying-jie FANG Li College of Animal Science and Technology Gansu Agricultural University Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture Institute of Animal ScienceChineseAcademy of Agricultural Sciences College of Animal Science and Technology Agricultural University of Hebei

On the basis of the ovine bone morphogenetic protein 15(BMP15)gene,two pairs of primers(PI and P2)were designed to amplify exons 1 and 2 of the BMP15 gene in five randomly selected does of both Angora and Jining Grey *** sequences of BMP15 exon 1(P1 amplification)of Angora and Jining Grey goats were *** was a 3-nucleotide(CTT)insertion in positions 268 to 270 of goat BMP 15 exon1 compared with that of sheep(GenBank accession number AF236078),which caused a leucine insertion in the 12th position of amino acid *** length of goat BMP 15 exon 2(P2 amplification)was identical with that of sheep(AF236079),but there were seven nucleotide and four amino acid changes between goat and *** nucleotide in the 963rd position of BMP15 exon 2 was A for Angora goat and sheep,and G for Jining Grey *** on this A963G mutation,primer pair P3 was designed to detect single nucleotide polymorphism of BMP15 exon 2 in breeds of high prolificacy(Jining Grey),moderate prolificacy(Boer)and low prolificacy(Angora and Inner Mongolia Cashmere)by polymerase chain reactionsingle strand conformation polymorphism(PCR-SSCP).Three genotypes(AA,AG and GG)were detected in Jining Grey goats,two genotypes(AG and GG)in Boer,and only the AA genotype in Angora and Inner Mongolia Cashmere *** revealed one mutation(A963G)in genotype GG compared with genotype AA,and this mutation resulted in an amino acid change of serine→glycine(S300G).In Jining Grey goats,frequencies of AA,AG and GG genotypes were 0.008,0.059 and 0.933,*** distributions of the BMP 15 gene were significantly different(P<0.05 or P<0.001)between Jining Grey and Boer,Angora,and Inner Mongolia Cashmere *** Jining Grey goats,the does with the GG genotype had 0.71(P<0.05)or 1.57(P<0.05)additional kids than did those with AG or AA genotypes,and does with the AG genotype had 0.86(P<0.05)more kids than did those with the AA *** results tentatively indicate that t

关键词： goat prolificacy bone morphogenetic protein 15 gene PCR-SSCP