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interstitial implantation of 125i seeds as salvage therapy for recurrent ovarian cancer and cervical cancer

Interstitial implantation of 125I seeds as salvage therapy f...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Jin-hua Huang 1,Chang-lun Li 1,Ji-hong Liu 2,Qi-dan Huang 2,Yang-gui Gu 1,Fei Gao 1 Authors’ Affiliations:1State Key Laboratory of Oncology in Southern China Department of Medical imaging & interventional Radiology,Cancer Center,Sun Yat-sen University,Guangzhou,Guang Dong,510060,PR China.2State Key Laboratory of Oncology in Southern China Department of Gynecology,Cancer Center,Sun Yat-sen University,Guangzhou, Guang Dong,510060,PR China. Corresponding Author:Jin-hua Huang,Department of Medical imaging & interventional Radiology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong 510060,P.R.China.Tel:+86-20-87343247 Fax:+86-20- 87343272.Email:hjinh@***.

Objective To investigate the feasibility,short-term efficacy and adverse effects of 125i seeds implantation in the treatment of recurrent ovarian cancer and cervical *** A total of 12 patients with recurrent ovarian cancer and 17 patients with cervical cancer treated in Sun Yat-sen University Cancer Center from June 2009 to December 2010 enrolled into the *** there were 49 lesions including 25 ovarian cancer lesions and 24 cervical ***-five lesions were treated with 125 i seed *** ovarian cancer lesions in liver and one lesion in spleen were treated with microwave ***-four lesions were treated under the guidance of CT while only one lesion in one patient was treated under the guidance of real-time *** treating plan was calculated using computerized treatment planning system(TPS) and Memorial Sloan-Ketterin nomograph according to the physiologic 18FDG uptake image in the *** prescribed matched peripheral dose(MPD) was 100～160 Gy. The total number of sources implanted were 6～68 with a median number of *** chemotherapy was given to 13 patients after the interventional *** status were evaluated with CT and 18F-FDG PET/CT findings. Results One patient with recurrent ovarian cancer and 9 patients with recurrent cervical cancer died and the other patients were still alive after a median follow-up of 15 mouths(range from 5 to 19mouths).Thirteen patients showed complete remission,seven patients showed partial remission,nine patients had progressive *** effective rate was 69.0% (20/29).There were three patient suffered from Sciatic nerve injury *** complication was found in the other *** 125 i seed implantation was feasible,effective and safe as a salvage local treatment for patients with recurrent gynecologic malignancies,it was worth of development and *** efficacy seems better in recurrent ovarian cancer than in cervical cancer patients.

关键词： ovarian cancer cervical cancer recurrent 125 i seed implantation 18F-FDG PET/CT

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