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Silica-supported Perchloric Acid Catalyzed One-pot Synthesis of 1,4-dihydropyridines

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Chinese Journal of Chemistry 2011年第11期29卷 2471-2475页

作者： Ramesh, Dasari Rajaram, Singanaboina Narasimhulu, Manchala Reddy, Thummalpally Srikanth Mahesh, Kondempudi Chinni Manasa, Gajji Venkateswarlu, Yenamandra Natural Products Laboratory Organic Chemistry Division-I Indian Institute of Chemical Technology Hyderabad-500 007 India

An environmentally friendly and highly efficient procedure for the preparation of 1,4-dihydropyridines by the reaction between a,β-unsaturated aldehydes, aromatic amines and β-keto esters in the presence of silica s... 详细信息

关键词： 1,4-dihydropyridines silica supported perchloric acid Hantzsch reaction β-keto esters

Synthesis and anticholinesterase activity of a novel series of acetazolamide condensed 1,4-dihydropyridines

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Carbon Resources Conversion 2019年第3期2卷 191-197页

作者： Mudduluru Niranjan Babu Karthikeyan Elumalai Sivaneswari Srinivasan Kalpana Eluri Manogaran Elumalai Srinivasan Sivannan Department of Phytochemistry Seven Hills College of PharmacyTirupati 517561India Department of Medicinal Chemistry Seven Hills College of PharmacyTirupati 517561India Department of Pharmaceutics K.K.College of PharmacyChennai 600122India Faculty of Pharmaceutical Sciences UCSI UniversityCherasKuala Lumpur 56000Malaysia Department of Pharmacy Practice Togari Veeramallappa Memorial College of PharmacyBallariIndia

A novel Acetazolamide condensed 1,4-dihydropyridines was set up by treating of N-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonyl)-3-oxobutanamide with an aryl aldehyde and 25-30%alkali with sight amount of barium nitrate as a *** of the synthetic structure of the titled compounds(4-16)was substantiated by thin-layer chromatography(TLC),IR,^(1)H NMR,^(13)C NMR,Mass spectra(MS)and elemental analysis(C,H,and N)were *** titled compounds were assessed for anticholinesterase activity against acetylcholinesterase and butyl cholinesterase *** titled compound produced weak,moderate,or high anticholinesterase ***,compound 8 demonstrated the best anticholinesterase activity of all the 1,4-dihydropyridines,with an IC_(50) estimation of 0.08μM and 2.9μM.

关键词： Acetazolamide Anticholinesterase 1,4-dihydropyridines Acetylcholinesterase Butyl cholinesterase

An Efficient, Three-component One-pot Preparation of 1,4-dihydropyridines Containing Novel Substituted Pyrazole under Sulfamic Acid Catalysis

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Chinese Journal of Chemistry 2011年第3期29卷 511-514页

作者： Li, Jianping Qiu, Jikuan Li, Huijuan Zhang, Guisheng College of Chemistry and Environmental Science Key Labaratory of Green Chemical Media and Reactions Ministry of Education Henan Normal University Xinxiang Henan 453007 China

An efficient approach to 1,4-dihydropyridines containing novel substituted pyrazole is achieved via threecomponent reaction of pyrazolyl aldehyde, β-ketoester, and ammonium acetate in one-pot under sulfamic acid cata... 详细信息

关键词： Hantzsch reaction 1,4-dihydropyridines pyrazole sulfamic acid catalysis synthesis

An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

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Science China Chemistry 2010年第7期53卷 1509-1513页

作者： LI Hui YU JinLong CAO Song SHEN Li WU MingXi CHENG JianHang QIAN XuHong Shanghai Key Laboratory of Chemical Biology Center of Fluorine Chemical TechnologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA),a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free *** comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate,ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.

关键词： three-component difluoromethyl 1,4-dihydropyridines ethyl difluoroacetoacetate

LiBr as an Efficient Catalyst for One-pot Synthesis of Hantzsch 1,4-dihydropyridines under Mild Conditions

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Chinese Journal of Chemistry 2011年第1期29卷 118-122页

作者： Yadav, D. K. Patel, R. Srivastava, V. P. Watal, G. Yadav, L. D. S. Alternative Therapeutics Unit Drug Development Division Medicinal Research Lab Department of Chemistry University of Allahabad Allahabad 211002 India Green Synthesis Lab Department of Chemistry University ofAllahabad Allahabad 211002 India

A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridines has been accomplished via lithium bromide-catalyzed Hantzsch three-component condensation reaction of an aldehyde, α,β-ketoester and ammonium acetate in acetonitrile at room temperature in good to excellent yields. The present protocol is applicable to wide range of substrates including aliphatic, aromatic and heterocyclic aldehydes affording 1,4-dihydropyridines.

关键词： Hantzsch reaction 1,4-dihydropyridines lithium bromide cyclization one-pot procedure multicomponent reactions

Synthesis of the 4-Aryl-1,4-dihydropyridines

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Synthesis of the 4-Aryl-1,4-dihydropyridines

Multicomponent Reaction in Ionic Liquid: A Novel and Green Synthesis of 1, 4-Dihydropyridine Derivatives

中国化学会第二十五届学术年会

作者： Peng Li, Hu Su, Hong Yan* College of Life Science and Bio-engineering, Beijing University of Technology, Beijing, 100022

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Chinese Chemical Letters 2006年第2期17卷 150-152页

作者： Xin Ying ZHANG Yan Zhen LI Xue Sen FAN Gui Rong QU Xue Yuan HU Jian Ji WANG College of Chemistry and Environmental Science Henan Key Laboratory for Environmental Pollution Control Henan Normal University Xinxiang 453007

An efficient and green method for the synthesis of 1, 4-dihydropyridine derivatives mediated in an ionic liquid, [bmim][BF4], through a four-component condensation process of aldehydes, 1, 3-dione, Meldrum＇s acid and... 详细信息

关键词： 1,4-dihydropyridines ionic liquids multicomponent reaction green chemistry.