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Catalyst-free and solvent-free method for the synthesis of quinoxalines under microwave irradiation

Chinese Chemical Letters 2009年第6期20卷 672-675页

作者： Jian Feng Zhou Gui Xia Gong Kun Bao Shi San Jun Zhi Department of Chemistry Huaiyin Teachers College Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials Huaian 223300 China School of Chemistry and Chemical Engineering Key Laboratory of Organic Synthesis of Jiangsu Province Suzhou University Suzhou 215123 China

A facile procedure for the synthesis, of quinoxalines is being reported starting from benzil and 1,2-diaminobenzene. The reactions were carried out catalyst-free, solvent-free and under microwave irradiation conditions in high yield （84-98%） with short time （3-6 min） and environmental benign, as well as convenient operation. The structures of all the compounds have been confirmed on the basis of their IR, 1H NMR, and/or 13C NMR, mass spectral data.

关键词： Quinoxaline Benzil 1,2-diaminobenzene Catalyst-free Solvent-free Microwave irradiation

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One-pot synthesis of 1,5-benzazepines(benzodiazepine, benzoxazepine,benzothiazepine)

One-pot synthesis of 1,5-benzazepines(benzodiazepine, benzox...

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中国化学会·第十五届全国有机合成化学学术研讨会

作者： Laiyun Zhou 王兰芝 The College of Chemistry and Material Science Hebei Normal University 河北师范大学

1,5-benzazepines is a kind of extremely significant compounds, which have high biologicaland pharmacological activity in the last decades. Such as antidepressant, anticonvulsant, sleep,anti-cramping and sedation.1,5-benzazepines compounds as anti-anxiety synthetic drugs have been used *** studies have shown that these compounds also have excellent anti-inflammatory activity. Therefore, in recent years, more and more researchers pay attention to the synthesis of 1,5-benzazepines. So in this article, one-pot synthesis of 1,5-benzazepines compounds including 1,5-benzodiazepine, 1,5-benzoxazepine, 1,5-benzothiazepine are developed under refluxing toluene from 2-aminobenzenethiol, 2-aminobenzenephenol or 1,2-diaminobenzene and ethyl acetoacetate as raw materials(Scheme 1).The reaction mixture was refiuxed for 4 hours and the solvent was distilled off, and then the residue was left overnight at room temperature and products were recrystallised with dry *** target compounds are determined by H NMR, C NMR, MS, and *** operation, short reaction time, high yields(85%-93%) are the advantages of this synthesis *** work not only enriches the type of 1,5-benzazepines, but also provides a reference for the future synthesis.

关键词： 1,5-benzazepines synthesis 2-aminobenzenethiol 2-aminobenzenephenol 1,2-diaminobenzene

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