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Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

World Journal of Gastroenterology 2016年第27期22卷 6224-6234页

作者： Takafumi Saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga Tomohiro Katsumi Kei Mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko Maki Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga Department of Gastroenterology Yamagata University School of Medicine Institute for Advanced Biosciences Keio University

AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome ***: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), ***: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P -glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.

关键词： Metabolome Hepatocellular carcinoma γ -glutamyl peptides Glutathione Oxidative stress

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