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Barrett食管化生的柱状上皮表达erbB2,而不表达erbB3

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 17-18页

作者： Nishigaki H. Wada K. TatsuguchiA. 陈云茹 Third Dept. of Internal Medicine Nippon Medical School 1-1-5 Sendagi Bunkyo ku Tokyo 113-8603 Japan Dr.

Background/Aims: ErbB2 expression in esophageal adenocarcinoma has been shown to correlate with its clinicopathological features. However, expression levels for EGF receptor, erbB2 and erbB3 in specialized columnar epithelium (SCE)of Barrett’s esophagus have yet to be determined. To investigate the relationship between EGF family receptors and Barrett’s esophagus, we examined expression levels for EGF receptor, erbB2 and erbB3 in SCE of Barrett’s esophagus. Methods: 10 consecutive patients with short and long segment Barrett’s esophagus, and 10 control subjects without organic esophagogastric diseases were enrolled. Biopsy samples of Barrett’s mucosa stained or not stained with methylene blue applied endoscopically were used for histological evaluation and Western blot analysis of EGF receptor, erbB2 and erbB3 proteins. Results: Mean length of Barrett’s esophagus was 2.6 cm (range 1-8 cm) and all tissue samples from methylene blue stained Barretts mucosa consisted of non dysplastic SCE. In the Barretts group, Western blot analysis showed that EGF receptor and erbB2 were equally and strongly expressed in SCE and squamous epithelium; in contrast, erbB3 expression in SCE was considerably weaker. In control subjects, all proteins showed strong expression for all samples. Immunohistochemical analysis of SCE in Barretts esophagus showed positive EGF receptor and erbB2 expression, and no erbB3 expression. Conclusions: ErbB2 is strongly expressed in both non dysplastic SCE and squamous epithelium, whereas erbB3 expression is essentially limited to the squamous epithelium.

关键词：柱状上皮 Barrett erbB2 erbB3 短节段亚甲蓝染色黏膜活检鳞状上皮细胞免疫组化分析不典型增生

特异性睑结膜炎患者泪液中ⅡA组磷脂酶A2的含量

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 36-37页

作者： Peuravuori H. Kari O. Peltonen S. K.M. Saari 秦雪娇 Department of Ophthalmol ogy University of Turku 20520 Turku Finland

Background: To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with atopic blepharoconjunctivitis (ABC), and to compare it with the GIIAPLA2 conce ntration of tears in age-matched healthy controls. Methods: The diagnosis of AB C was confirmed with a positive skin prick test and the presence of atopic derma titis in lids. Conjunctival brush cytology was taken, and the cells including eo sinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithel ial cells, metaplastic changes and the goblet cells were calculated separately. The GIIAPLA2 concentration of tears was measured with a time-resolved fluoroimm unoassay in 29 patients with ABC (mean age 36.3±12.7 years) and 29 normal subje cts (mean age 37.0±12.0 years). Results: The GIIAPLA2 concentration of tears in patients with ABC was 43.8±33.0 μg/ml, and in normal subjects it was 67.1±23 .3 μg/ml. The difference was statistically significant (P=0.001 8). The concent ration of GIIAPLA2 of tears was lowest in the subgroup of patients with ABC and dry eye (25.8 ±23.6 μg/ml), whereas it was only slightly decreased in patients with ABC and normal tear secretion (56.6±33.3 μg/ml). The difference between these two subgroups was statistically significant (P=0.011). There was no statis tically significant correlation between the GIIAPLA2 concentration of tears and the quantity of different conjunctival cells gathered by the brush cytology. How ever, an almost significant correlation was found between the GIIAPLA2 concentra tion in tears and conjunctival eosinophils. Conclusions: The results indicate th at in patients with ABC the GIIAPLA2 content of tears was decreased, without any dependence on the quantity of different conjunctival cells.

关键词：睑结膜炎磷脂酶特异性结膜细胞鳞状上皮细胞皮肤针刺试验干眼症患者嗜酸性细胞杯状细胞柱状上皮细胞

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聚焦超声治疗外阴白色病变的回顾性研究

新疆医学 2015年第2期45卷 237-239页

作者：龙燕王建凤新疆生产建设兵团第二师库尔勒医院妇科新疆库尔勒841000

外阴上皮内瘤样变（也称外阴白色病变）是女性外阴皮肤和黏膜组织色素改变和变性的一组慢性疾病,包括鳞状上皮细胞增生、硬化性苔藓及其它皮肤病。外阴白色病变是一种妇科常见的难治性疾病,目前病因尚不明确,临床常规治疗方法虽然有一... 详细信息

外阴上皮内瘤样变（也称外阴白色病变）是女性外阴皮肤和黏膜组织色素改变和变性的一组慢性疾病,包括鳞状上皮细胞增生、硬化性苔藓及其它皮肤病。外阴白色病变是一种妇科常见的难治性疾病,目前病因尚不明确,临床常规治疗方法虽然有一定疗效,但是复发率较高。

关键词：外阴白色病变聚焦超声治疗仪硬化性苔藓上皮内瘤外阴皮肤复发率慢性疾病色素改变鳞状上皮细胞

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青春期宫颈非典型性增生

世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 56-57页

作者： Wright J.D Davila R.M Pinto K.R 王伟华 Division of Gyneco logic Oncology Department of Obstetrics Washington University School of Medicine 4911 Barnes Hospital Plaza St. Louis MO 63110 United States.Dr

Background: Although the incidence of cervical dysplasia in adolescents is increasing, a paucity of data exists regarding the outcomes of adolescents with Pap test abnormalities. We determined the natural history and outcome of adolescents with low- grade squamous intraepithelial lesions (LSIL) and highgrade squamous intraepithelial lesions (HSIL). Methods: A review of ail women aged 18 years or younger with a cytologic diagnosis of LSIL or HSIL between 1997 and 2003 was performed. Follow- up cytologic and histologic samples were evaluated. The most significant abnormality was recorded for each patient. Rates of regression, persistence, and progression were calculated. Results: A total of 646 arolescents were identified. Follow- up was available for 477 teenagers with LSIL and for 55 with HSIL. Among adolescents with LSIL, 146 (35% ) had negative follow- up. Low- grade abnormalities (atypical squamous cells of undetermined significance, LSIL, and cervical intraepithelial neoplasia grade 1) were seen in 199 (47% ), whereas high- grade abnormalities were documented in 77 (18% ). After 36 months, 62% had regressed, whereas 31% had progressive dysplasia. For the HSIL cohort, negative follow- up was documented in 12 (21.8% ) adolescents, and 15(27.3% ) had low- grade abnormalities, whereas more than one half (50.9% ) were found to have a high- grade abnormality. At 36 months, 31% of HSIL subjects had progressed to cervical intraepithelial neoplasia 3. Conclusion: Adolescents with LSIL and HSIL cytology are at significant risk for progression to high- grade cervical abnormalities. The rate of development of high- grade cervical abnormalities in adolescents is similar to adults. Adolescents with cytologic abnormalities mandate close follow- up.

关键词：非典型性增生鳞状上皮细胞巴氏涂片上皮内瘤细胞学诊断性发育异常细胞学异常青春期女性自然史细胞染色

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尿液中颗粒物检测标准化的参考程序

江西医学检验 2007年第5期25卷 496-497,436页

作者：李胜远姜青龙万本愿江西省临床检验中心南昌330006

1前言　尿液颗粒计数自动化要求标准化的参考程序提供校准物,并保证其结果精确性和有效性。国际血液实验室特别工作组提议一份参考程序,范围涉及尿液的红细胞、白细胞、管型成分、鳞状上皮细胞。它以ISO/DIS（国际标准化委员会）草案国... 详细信息

1前言　尿液颗粒计数自动化要求标准化的参考程序提供校准物,并保证其结果精确性和有效性。国际血液实验室特别工作组提议一份参考程序,范围涉及尿液的红细胞、白细胞、管型成分、鳞状上皮细胞。它以ISO/DIS（国际标准化委员会）草案国际标准78-2为基础,同时参考了ISO/CD15195,考虑了检测物与检测要求,在现有模式的结构基础上发展起来。

关键词：检测标准化程序尿液颗粒物国际标准化鳞状上皮细胞血液实验室颗粒计数

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妇女病普查结果4367例分析

基层医学论坛 2017年第7期21卷 887-888页

作者：鲍国波余姚市陆埠中心卫生院浙江余姚315420

妇女病普查是政府为民办实事的一项重要惠民工程,通过检查,能够使妇科常见病、多发病早发现,早诊断,早治疗,早康复。2015年4月—7月我院对辖区范围内20岁~64岁的4 367例已婚妇女进行了普查,现将普查内容和结果报告如下。

关键词：妇女病普查普查内容妇女主任鳞状上皮内病变普查普治鳞状上皮细胞子宫腺肌病肌层阴道分泌物育龄期

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宫颈糜烂与生活作风无关

科学新生活 2013年第6期 28-29页

作者：王硕

有时是宫颈癌的保护色又是一年三八妇女节,就在大多数女同胞关注如何提升自身健康时,却有一些人因宫颈糜烂而惶恐不安。妇科专家指出,单纯的"宫颈糜烂"、没有异样的宫颈炎一般都不必进行治疗,更不必担心会诱发宫颈癌。

关键词：宫颈糜烂生活作风阴道炎症人乳头瘤病毒妇科炎症鳞状上皮细胞细菌性阴道炎妇科专家宫颈管

埃索美拉唑治疗Barrett食管的疗效观察

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浙江预防医学 2006年第6期18卷 68-69页

作者：郑卫华浙江省人民医院浙江杭州310014

Barrett食管(Barrett Esophagus BE)是指食管下段复层鳞状上皮细胞被单层柱状上皮细胞所取代,以食管与胃粘膜交界的连接线(齿状线)为界,在齿状线2cm以上出现柱状上皮细胞者,即为Barrett食管.研究表明,BE是一种癌前病变,与食管腺癌密切相... 详细信息

Barrett食管(Barrett Esophagus BE)是指食管下段复层鳞状上皮细胞被单层柱状上皮细胞所取代,以食管与胃粘膜交界的连接线(齿状线)为界,在齿状线2cm以上出现柱状上皮细胞者,即为Barrett食管.研究表明,BE是一种癌前病变,与食管腺癌密切相关[1].本文报道我院1999年以来胃镜检查后确诊的34例BE患者,应用埃索美拉唑与奥美拉唑治疗后,对其症状缓解及BE上皮细胞的逆转情况分析报道如下.

关键词：疗Barrett食管埃索美拉唑疗效观察 Esophagus 柱状上皮细胞鳞状上皮细胞食管下段癌前病变食管腺癌奥美拉唑

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沅湘流不尽屈子怨何深

中国医学人文 2023年第7期9卷 28-28页

作者：胡佐鸿成都市第一人民医院

过三闾庙。唐戴叔伦。湘流不尽,屈子怨何深。日暮秋风起,萧萧枫树林。赏析:图1来自纤支镜液基刷片,横贯图中心的“不尽沅湘”之流其实是支气管分泌的黏液,不过从液态的角度来讲,两者并不是风马牛不相及的。在黏液两侧散着一些支气管纤... 详细信息

过三闾庙。唐戴叔伦。湘流不尽,屈子怨何深。日暮秋风起,萧萧枫树林。赏析:图1来自纤支镜液基刷片,横贯图中心的“不尽沅湘”之流其实是支气管分泌的黏液,不过从液态的角度来讲,两者并不是风马牛不相及的。在黏液两侧散着一些支气管纤毛柱状上皮细胞、小淋巴细胞及个别鳞状上皮细胞,那是人们投入江中为祭屈子的粽子吗?

关键词：鳞状上皮细胞小淋巴细胞刷片纤支镜戴叔伦屈子沅湘支气管