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世界核心医学期刊文摘（眼科学分册） 2003年第4期 781-800页

人类免疫缺陷病毒感染的儿童恶性肿瘤发生的危险因素目的虽然癌症在感染了人类免疫缺陷病毒(HIV)的儿童的发生率明显增高,但对于恶性肿瘤的发生,明确的临床的、免疫学的和病毒的相关危险因素还没有被确认。本研究的目的确认HIV感染的... 详细信息

人类免疫缺陷病毒感染的儿童恶性肿瘤发生的危险因素目的虽然癌症在感染了人类免疫缺陷病毒(HIV)的儿童的发生率明显增高,但对于恶性肿瘤的发生,明确的临床的、免疫学的和病毒的相关危险因素还没有被确认。本研究的目的确认HIV感染的儿童中恶性肿瘤发生的危险因素。方法在儿科肿瘤学研究协会的26个研究院内对HIV感染的患儿进行一个多中心的病例对照研究。将HIV感染期间的43例有新发恶性肿瘤的病例和74例没有肿瘤发生的病例对照组相比。患者是1992-

关键词：儿童恶性肿瘤慢性肝病患者儿科肿瘤学 antiretroviral 细胞计数病例对照研究星形细胞瘤胰岛素抵抗非进展性羊膜穿刺术

葡萄膜黑色素细胞瘤:葡萄膜和皮肤恶性黑色素瘤的遗传学比较

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 20-21页

作者： Fogt F Selim A.M 曹绪胜 Department of Pathology and Laboratory Medicine Presbyterian Medical Center University of Pennsylvania 39th and Market streets Philadelphia PA 19104 United States.Dr

Objective: Melanocytomas of the eye are typically benign tumors that may be associated with nevi and melanomas. In this study, we assessed the genetic data of melanocytomas and compared them with nevi and melanomas of both the eyes and the skin. Design: We microdissected 8 melanocytomas, 13 uveal melanomas, and 10 cutaneous melanomas and analyzed loss of heterozygosity markers on chromosome bands 1p36, 6q22- 23.3, 9p21, and 10q23, which represent genetic loci associated with advanced dermalmelanocytic lesions. Results: There was no loss of heterozygosity in any of the melanocytomas. However, many loss of heterozygosity events were found in uveal and cutaneous melanomas, most frequently involving chromosome 1 damage followed by chromosome 9 and 10 alterations. Conclusion: Based on the absence of loss of heterozygosity in melanocytomas, specifically the locus that is lost most often in dysplastic nevi of the skin, we conclude that melanocytomas represent an entity that is different from melanomas or may be similar to that of dermal benign nevi. Clinical Relevance: Our results confirm that melanocytomas represent nonagressive lesions that do not demand radical surgery.

关键词：色素细胞瘤葡萄膜恶性黑色素瘤皮肤黑色素皮肤色素痣非进展性杂合性细胞病变临床相关性根治性手术

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无色素痣的临床和组织病理学特点

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 10-11页

作者： Kim S.K. Lee E.-S. Kim Y.C. 王琼

Background: Nevus depigmentosus (ND) is known to be a rare congenital, nonprogressive disorder characterized by a hypopigmented lesion that remains stable over time. There have been only few studies of clinical and histopathologic characteristics of ND, and the etiopathogenesis is not fully established. Objective: The purpose of this study was to investigate the clinical and histopathologic characteristics of ND. Methods: A clinical survey was carried out with 60 patients given the diagnosis of ND. Punch biopsies (2 mm) from lesional and perilesional normal skin were performed. The sections were stained with hematoxylin-eosin, Fontana-Masson, antibodies to S-100 protein, MART-1, NKI/beteb, CD1a, CD3, CD20, and CD68. Results: The lesions were usually present before the age of 3 years (68.3%), but some lesions appeared later in childhood (31.7%). In all, 27 patients (45%) had one lesion, but there were 14 patients (23.3%) who had more than 10 lesions. Fontana-Masson stain showed that the amount of melanin was significantly decreased in ND skin compared with perilesional normal skin. Melanocyte counts were significantly decreased in ND skin when stained with antibodies to GP-100 and MART-1. However, there were no significant differences in the number of melanocytes identified as S-100 protein-positive cells. There were no significant differences in histologic findings or dermal inflammatory infiltrates between ND skin and perilesional normal skin. Limitations: Only 29 patients (48.3%)were followed up, and the average follow-up period after initial diagnosis was relatively short (68 months); therefore, these overall results may not be representative of the clinical course of the patients. Conclusion: Only 18 patients (30.0%) presented with ND since birth and only 27 patients (45.0%) had one lesion. Both the amount of melanin and the number of melanocytes in ND skin were decreased in patients with ND. Therefore, both clinical and histologic findings should be considered

关键词：无色素痣病理学特点黑素细胞总体结果非进展性病理学研究临床调查苏木素炎症浸润童期

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传染病寄生虫病

国际内科学杂志 1996年第5期 225-227页

传染病寄生虫病１４８长期非进展性人类免疫缺陷病毒感染的研究［英］／ＰａｎｔａｌｅｏＧ…∥Ｎ　ＥｎｇｌＪＭｅｄ．－１９９５，３３２（４）．－２０９～２１６人类免疫缺陷病毒（ＨＩＶ）感染的潜伏期变化较大，发展成获得性免疫... 详细信息

传染病寄生虫病１４８长期非进展性人类免疫缺陷病毒感染的研究［英］／ＰａｎｔａｌｅｏＧ…∥Ｎ　ＥｎｇｌＪＭｅｄ．－１９９５，３３２（４）．－２０９～２１６人类免疫缺陷病毒（ＨＩＶ）感染的潜伏期变化较大，发展成获得性免疫缺陷综合征（ＡＩＤＳ）平均需时８～...

关键词：头孢三嗪抗药性耐药性抗药菌株肺炎球菌感染头孢菌素非进展性伊他康唑依他康唑敏感菌株头孢霉素头孢噻肟传染性疾病疾病传染病抗菌素青霉素艾滋病病毒病获得性免疫缺陷综合征肺炎双球菌链球菌属肺炎链球菌二性霉素人类免疫缺陷病毒感染寄生虫感染寄生虫病

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进展性脑梗死危险因素分析

检验医学与临床 2013年第21期10卷 2869-2870页

作者：刘春梅陈文刚河北省唐山市玉田县医院内二科 064100

目的探讨进展性脑梗死患者的危险因素。方法将玉田县医院2010～2012年收治的53例进展性脑梗死患者(进展组)作为研究对象,对其临床资料进行回顾性分析,主要分析的资料有病患血糖、血压、体温、血脂等,并将进展组病患临床资料相关情况与... 详细信息

目的探讨进展性脑梗死患者的危险因素。方法将玉田县医院2010～2012年收治的53例进展性脑梗死患者(进展组)作为研究对象,对其临床资料进行回顾性分析,主要分析的资料有病患血糖、血压、体温、血脂等,并将进展组病患临床资料相关情况与同期随机抽取的非进展组(非进展性脑梗死)53例病患资料进行对比分析。结果在53例进展性脑梗死患者中,出现了30例合并糖尿病、31例原发性高血压、24例血脂升高,与同期非进展组差异有统计学意义(P进展性脑梗死而言,其主要的危险因素有糖尿病、高血压、发热、高脂血症及血管狭窄等。

关键词：进展性非进展性脑梗死危险因素分析

短暂性脑缺血发作、延迟性短暂性脑缺血发作、和完全性卒中

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国外医学.神经病学神经外科学分册 1985年第2期 102-102页

作者：庄作民

作者报导76例短暂性脑缺血发作(TIA),45例延迟性短暂性脑缺血发作(PTIA),85例小中风(又称部分性非进展性脑卒中、PNS)的自然病史和随访5～7年的研究结果,并对此进行了比较评价。由于 TIA 和 PTIA 最终均能完全恢复,作者将它们统称为可... 详细信息

作者报导76例短暂性脑缺血发作(TIA),45例延迟性短暂性脑缺血发作(PTIA),85例小中风(又称部分性非进展性脑卒中、PNS)的自然病史和随访5～7年的研究结果,并对此进行了比较评价。由于 TIA 和 PTIA 最终均能完全恢复,作者将它们统称为可逆性缺血发作(RIA)。在206例中男性136例(66%),女性70例(34%)。颈动脉受累较椎—基动脉受累常见(145例:53例)。颈动脉受累的特点是:(1)PTIA 的发病较 TIA 和 PNS 缓慢;(2)PNS 的运动障碍常以一侧为主,而 TIA 和 PTIA 常只累及一个肢体;(3)TIA 常有失语;(4)1/4PNS 病人有单侧感觉迟钝。椎—基动脉受累的特点是:(1)绝大多数的发作是突然的;(2)运动障碍常见于一侧,PNS 特别多见波及面肌、眼球运动系统及Ⅸ、Ⅹ、Ⅺ、Ⅻ颅神经;(3)也可见共济失调、视觉障碍、构音困难和感觉障碍等,而约半数的 TIA 病人有两侧对称性黑

关键词：完全性卒中延迟性非进展性感觉迟钝可逆性缺血感觉障碍自然病史构音困难眼球运动运动障碍

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局灶性癫痫全脑T2图证实存在潜在的异常

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 45-45页

作者： Rugg- Gunn F.J. Boulby P.A. Symms M.R. J.S. Duncan 姚庆和 National Society for Epilepsy Gerrards Cross Bucks SL9 0RJ United Kingdom Prof.

Objectives: To examine the cerebral structure of 14 patients with partial seizures and acquired lesions, 20 patients with malformations of cortical development (MCDs), and 45 patients with partial seizures and normal conventional MRI using whole- brain T2 mapping and statistical parametric mapping (SPM). Methods: T2 maps were calculated, and individual patients were compared with a group of 30 control subjects using SPM. Results: T2 mapping and objective voxel- by- voxel statistical comparison identified regions of increased T2 signal in all 14 patients with acquired nonprogressive cerebral lesions and partial seizures. In all of these, the areas of increased T2 signal concurred with abnormalities identified on visual inspection of conventional MRI. In 18 of 20 patients with MCDs, SPM detected regions of increased T2 signal, all of which corresponded to abnormalities identified on visual inspection of conventional MRI. In addition, in both groups, there were areas that were normal on conventional imaging, which demonstrated abnormal T2 signal. Voxel- by- voxel statistical analysis identified increased T2 signal in 23 of the 45 patients with cryptogenic focal epilepsy. In 20 of these, the areas of increased T2 signal concurred with epileptiform EEG abnormality and clinical seizure semiology. Group analysis of MRI- negative patients with electroclinical seizure onset localizing to the left and right temporal and left and right frontal regions revealed increased T2 signal within the white matter of each respective lobe. Conclusions: T2 mapping analyzed using statistical parametric mapping was sensitive in patients with malformations of cortical development and acquired cerebral damage. Increased T2 signal in individual and grouped MRInegative patients suggests that minor structural abnormalities exist in occult epileptogenic cerebral lesions.

关键词：局灶性癫痫 T2 信号增强临床发作非进展性脑损伤体素右颞叶谱分析法大脑结构

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皮肤T细胞淋巴瘤的免疫血清学标记

世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 29-29页

作者： Hassel J.C. Meier R Joller-Jemelka H. R. Dum-mer 田中伟 Department of Dermatology University Hospital of Zürich Switzerland Dr.

Introduction: As serological immunomarkers like neopterin, β2-microglobulin,solubleIL-2receptor(sIL-2R)andIL-6have been described to be elevated in various malignancies, the aim of this study was to investigate whether they would be of diagnostic and prognostic value for leukemic and non-leukemic cutaneous T cell lymphoma (CTCL). Patients and Methods: Forty-one CTCL patients from the lymphoma clinics of the Department of Dermatology, University of Zürich, were tested for the serum levels of the above-mentioned immunomarkers at several time points, and clinical status and clinical outcome were recorded. Thirty-nine patients with CBCL and T cell inflammatory diseases served as controls. Results: The study revealed that neopterin, β2-MG and sIL-2R are significantly elevated in Se′zary syndrome, whereby sIL-2R seemed to be the most sensitive marker and is typically increased in Se′zary syndrome. Moreover, there is a correlation between tumor burden index values and serum parameters. Concerning the outcome of the disease (progression versus non-progression), only neopterin showed a significant prognostic value in non-leukemic CTCL patients. Conclusion: Serological immunomarkers are helpful tools in determining the tumor burden in CTCL and thus might be useful for disease monitoring during treatment. They may have prognostic value for predicting the clinical course.

关键词：免疫血清淋巴瘤新蝶呤疾病检测肿瘤负荷非进展性血清免疫学临床状况感染性疾病微球蛋白