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中国书法 1998年第6期 72-74页

作者：黄君实

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继发性鳞状细胞癌3例

中国皮肤性病学杂志 1997年第3期11卷 41-42页

作者：杨冰心孙桂霞董云鹏吉林医学院附属医院皮肤科!132011 吉林医学院附属医院病理科

例1　女,56岁,农民。3岁始,先后在颈部、左耳前、口周及双眼眶周围发生豌豆至蚕豆大结节,溃烂不愈。曾服用雷米封,皮损好转形成瘢痕。4个月前,左耳前瘢痕处发生杏核大圆形隆起的肿物,无痛痒。后增至鸭卵至鹅卵大。中心破溃流血水。再服... 详细信息

例1　女,56岁,农民。3岁始,先后在颈部、左耳前、口周及双眼眶周围发生豌豆至蚕豆大结节,溃烂不愈。曾服用雷米封,皮损好转形成瘢痕。4个月前,左耳前瘢痕处发生杏核大圆形隆起的肿物,无痛痒。后增至鸭卵至鹅卵大。中心破溃流血水。再服雷米封无好转。体检:左耳前见10cm×10cm菜花样肿块,中心溃烂,有血性分泌物,恶臭。左颌下淋巴结如鸡卵大,质硬无压痛。组织病理示角化过度伴角化不全,棘层增厚,上皮脚下延。真皮内大片鳞状细胞样瘤细胞团,细胞异形性明显,见核分裂,角化不良细胞及少量角珠。诊断:瘢痕继发级鳞状细胞癌。例2　男,64岁,农民。3年前,骶尾部瘙痒,反复搔抓1年后,局部呈苔藓样变,中心部发生豌豆

关键词：鳞状细胞癌继发耳前异形性慢性湿疹癌巢雷米封异烟肼核分裂角化过度角珠

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书坛画苑

世界中学生文摘 2008年第5期 30-31页

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鳞状细胞癌和博温病紧密连接相关蛋白

世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 16-17页

作者： Morita K. Tsukita S. Miyachi Y. 刘超 Department of Dermatology Graduate School of Medicine Kyoto University Shogoinkawaharacho Sakyo-ku Kyoto 606-8507 Japan

Background: The epidermis, which is a typical stratified epithelium, has tight junctions (TJs) in the granular layer, as do simple epithelia. So far, abnormalities of TJs and involvement of claudin-1 have been reported in tumours of simple epithelia. Objectives: To examine the expression of TJ-associated proteins (occludin, ZO-1, claudin-1 and claudin-4) in normal human epidermis and in malignant disorders of keratinization. Methods: Expression of the proteins in normal human epidermis, five cases of squamous cell carcinoma (SCC) of the skin and five cases of Bowen’s disease (BD) was examined by immunofluorescence staining. Results: In normal human epidermis, occludin, ZO-1 and claudin-4 were expressed at the cell-cell borders in the granular layer specifically or dominantly, whereas claudin-1 was expressed in the whole epithelium. In SCC, occludin, ZO-1, claudin-1 and claudin-4 were strongly expressed in tumour cells with keratinization such as cancer pearls. Claudin-1 was heterogeneously expressed in unkeratinized tumour cells, whereas expression of occludin, ZO-1 and claudin-4 was decreased or absent. In BD, aberrant expression of occludin, ZO-1, claudin-1 and claudin-4 was observed at the cell-cell borders in addition to their expression patterns observed in normal epidermis. Conclusions: Expression of occludin. ZO-1 and claudin-4 is associated with keratinization in SCC and BD. However, the heterogeneous expression of claudin-1 in SCC is not determined only by keratinization.

关键词：博温病鳞状细胞癌正常上皮角化性疾病单层上皮角珠低表达颗粒层免疫荧光染色特异性

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皮肤疾病

中国中西医结合儿科学 1991年第5期 319-319页

911605 Kaposi水痘样疹1例/徐瑞云∥实用儿科杂志。-1991,6(3)。-146 女,8个月。生后2个月面肩部患大片湿疹至今未愈。检查:T39℃,面颊呈点状渗出及糜烂面,基底潮红,前额密布约3～4cm圆形水疱,其顶部均有脐窝状凹陷,肩背也散布上述疱疹... 详细信息

911605 Kaposi水痘样疹1例/徐瑞云∥实用儿科杂志。-1991,6(3)。-146 女,8个月。生后2个月面肩部患大片湿疹至今未愈。检查:T39℃,面颊呈点状渗出及糜烂面,基底潮红,前额密布约3～4cm圆形水疱,其顶部均有脐窝状凹陷,肩背也散布上述疱疹。经用黄连素湿敷,静滴洁霉素,皮疹结痂,脱痂后留有色素沉着。随访3个月色素消退。(林榕)

关键词：皮肤疾病糜烂面脐窝脱痂色素沉着徐瑞小汗腺痣洁霉素肩部角珠

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您的膳食结构合理吗?

家庭医学（上半月） 1994年第12期9卷 38-38页

作者：公孙宇

您的膳食结构合理吗?对此问题,许多人也许不以为然。

关键词：膳食结构膳食营养角珠石粉疼病食物食中构合士气维生