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挫伤性视网膜下纤维化(附二例报告)

中华眼外伤职业眼病杂志 1990年第S1期30卷 380-381页

作者：刘彭轩天津市眼科医院

眼球钝挫伤,可导致多种眼内病变。其中挫伤性视网膜下纤维化,属视网膜外层病变之一,临床不常见。近年国外对挫伤性视网膜外层病变已做了研究及动物试验。本病目前国内尚未见专题报道。特择两个典型病例报告如下。并试从发病机理、临床... 详细信息

眼球钝挫伤,可导致多种眼内病变。其中挫伤性视网膜下纤维化,属视网膜外层病变之一,临床不常见。近年国外对挫伤性视网膜外层病变已做了研究及动物试验。本病目前国内尚未见专题报道。特择两个典型病例报告如下。并试从发病机理、临床表现、眼底荧光血管造影特点及鉴别诊断方面,进行了讨论。

关键词：挫伤性视网膜外层眼球钝挫伤色素上皮脉络膜出血房角视网膜血管黄斑裂孔典型病例报告晶状体半脱位

眼底自发荧光与中心性浆液性脉络膜视网膜病变

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 56-57页

作者： Spaide R.F. Klancnik Jr. J.M. 吴琼 Vitreous Retina Macula Consult. N. 460 Park Avenue New York NY 10022 United States Dr.

Purpose: To investigate the autofluorescence characteristics in patients with central serous chorioretinopathy. Design: Observational case series. Participants: Thirty consecutive patients examined in a private referral practice. Methods: Patients were imaged with autofluorescence photography, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). The mean and standard deviation (SD) of the grayscale values from a 100-pixel-diameter circle centered on the fovea were obtained and normalized with the level of autofluorescence of the posterior pole. Results: There were 30 patients, 23 male (76.7%) and 7 female (23.3%), with a median visual acuity (VA) of 20/25 and a range of 20/15 to 20/400. Stepwise linear regression that included individual fixed effects found that normalized central macular autofluorescence (P < 0.001), pigment mottling in the fovea (P=0.045), subfoveal fluid detected by OCT (P=0.033), and the SD of the central macular autofluorescence (P=0.025) produced a highly significant model (R2=0.92, P< 0.001) predicting VA. Increasing levels of autofluorescence were correlated with accumulation of material on the outer surface of the retina as seen by OCT. Decreased central macular autofluorescence, particularly in those eyes with central geographic retinal pigment epithelial atrophy, was associated with poor VA. Conclusions: This study established that autofluorescence changes occurring in central serous chorioretinopathy with explicit patterns can be measured in a noninvasive manner, and this information can be used to estimate the damage induced by central serous chorioretinopathywith a high degree of statistical significance. We hypothesize that the material on the outer surface of the elevated retina may represent accumulation of photoreceptor outer segments secondary to the lack of direct apposition and phagocytosis by the retinal pigment epithelium.

关键词：自发荧光视网膜色素上皮中心凹眼底照相平均视力荧光造影视网膜外层光感受器后极部外节

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脉络膜骨瘤

眼科 2024年第3期33卷 177-177页

作者：赵振波唐凯莉夏建平马立威张劲松安徽医科大学附属爱尔眼科医院合肥230031 沈阳爱尔卓越眼科医院沈阳110001

男性,63岁。左眼视力下降3年。左眼检查:视力0.3,眼压15 mmHg。眼前节未见明显异常。45°眼底像与广角眼底像:视盘边界清色稍淡,视盘颞上方视网膜可见黄白色地图状病灶,表面呈丘陵状起伏,伴色素沉着,累及黄斑部,视网膜平复在位,未见明... 详细信息

男性,63岁。左眼视力下降3年。左眼检查:视力0.3,眼压15 mmHg。眼前节未见明显异常。45°眼底像与广角眼底像:视盘边界清色稍淡,视盘颞上方视网膜可见黄白色地图状病灶,表面呈丘陵状起伏,伴色素沉着,累及黄斑部,视网膜平复在位,未见明显出血(图A、B);EDI-OCT:左眼病灶部形态呈波纹状,视网膜外层结构不清,RPE层厚度不均伴局灶性隆起,脉络膜组织形态改变(图C);眼B超:左眼玻璃体腔近视盘部可见圆形肿瘤样强反射(图D);眼眶CT:左眼眼球后壁可见弧形高密度影(接近眶骨密度),增强扫描未见强化(图E)。诊断:左眼脉络膜骨瘤。

关键词：左眼视力黄斑部眼前节视网膜外层眶骨色素沉着波纹状视盘

多发性一过性白点综合征的非典型表现——大小不一的颗粒状病变

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 25-25页

作者： Khurana R.N. Albini T. Dea M.K. J.I. Lim 韩静 Doheny Eye Institute University of Southern California Keck School of Medicine 1450 San Pablo Street No. 3612 Los Angeles CA 90033 United States Dr.

PURPOSE: To report an atypical presentation of multiple evanescent white dot syndrome (MEWDS). DESIGN: Observational case report. METHODS: Review of the clinical, laboratory, photographic, and angiographic records of a patient with MEWDS. RESULTS: A 29-year-old woman presented with 20/400 vision in the right eye associated with multiple, granular lesions of varying sizes (100-1000 μm) in the outer retina, a prominent panuveitis, diffuse choroidal thickening and enlarged blindspot. The multiple lesions and visual disturbances resolved within 4 weeks with corticosteroid treatment, and the patient was diagnosed with MEWDS. CONCLUSIONS: Clinicians should be aware of atypical manifestations of MEWDS. The patient’s unusual fundoscopic changes and prominent intraocular inflammatory reaction are findings that have not been reported in patients with MEWDS.

关键词：颗粒状眼底改变视网膜外层右眼视力葡萄膜炎临床医生炎症反应血管造影糖皮质激素观察性

1例日本白点状视网膜炎患者的RLBP1基因新突变

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 23-23页

作者： Nakamura M. Ito Y. Miyake Y. 杨秀梅 Department of Ophthalmol ogy Nagoya University Graduate School of Medicine 65 Tsuruma-cho Showa-ku Nagoya 466-8550 Japan Dr.

PURPOSE: To report a novel mutation in the RLBP1 gene and optical coherence to mographic findings in a Japanese patient with retinitis punctata albescens. DESI GN: Observational case report. METHODS: The RLBP1 gene was analyzed by direct ge nomic sequencing. A complete ophthalmologic examination was performed. RESULTS: Compound heterozygous mutations in the RLBP1 gene were identified in the patient . The mutations were a novel missense Arg103Trp mutation and a missense Arg234Tr p mutation, the causative mutation of Bothnia dystrophy. The patient’s fundi sh owed numerouswhite dots with diffuse retinalmottling and bilateralmacular degene ration. Her visual function deteriorated progressively during 12-year follow-u p. Optical coherence tomography demonstrated decreased retinal thickness, especi ally the photoreceptor layer. CONCLUSION: A novel mutation in RLBP1 gene was fou nd in a Japanese patient with retinitis punctata albescens. Degenerative changes of the outer retina were detected by optical coherence tomography.

关键词：视网膜炎 RLBP1 光感受器视网膜外层眼部检查黄斑变性视功能杂合突变精氨酸观察性