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国外医学（医院管理分册） 1998年第3期15卷 130-131页

作者：张丽娟王钦富于增国大连大学医学院

本文就ＰａｔｒｉｃｉａＭ在１９９６年ＴｈｅＮｅｗＥｎｇｌａｎｄＪｏｕｎａｌｏｆＭｅｄｉｃｉｎｅ杂志发表的题为医学生职业接触血液传播病毒一文重点评述了美国医学院校实习生实习中发生职业性感染血液传播病毒的风险及感染后医疗... 详细信息

本文就ＰａｔｒｉｃｉａＭ在１９９６年ＴｈｅＮｅｗＥｎｇｌａｎｄＪｏｕｎａｌｏｆＭｅｄｉｃｉｎｅ杂志发表的题为医学生职业接触血液传播病毒一文重点评述了美国医学院校实习生实习中发生职业性感染血液传播病毒的风险及感染后医疗费用支付中存在的问题。同时对医学院校、教学医院及社会有关部门提出了加强教育、管理及应采取的有关政策。

关键词：血液传播病毒感染职业性医学生风险对策

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Study on the blood-borne virus co-infection and T lymphocyte subset among intravenous drug users

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World Journal of Gastroenterology 2007年第16期13卷 2357-2362页

作者： Jian-Rong Li Rui-Yu Gong Kun-Lun Tian Jing Wang Yi-Xin Wang Han-Ju Huang Department of Pathogenic Biology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Basic Medical Department Dali College Dali 671000 Yunnan Province China

AIM: To investigate the features of various blood- borne virus infections and co-infection in intravenous drug users (IDUs), and to examine the correlation of T lymphocyte subsets with virus co-infection. METHODS: Four hundred and six IDUs without any clinical manifestation of hepatitis and 102 healthy persons were enrolled in this study. HBV-DNA and HCV-RNA were detected by fluorescence quantitative PCR. HBsAg, HBeAg, anti-HBc, anti-HCV, HDV-Ag, anti-HGV, anti-HIV, and HCMV-IgM were assayed by enzyme-linked immunosorbent assay (ELISA) and immunochromatographic tests. The levels of Th1 and Th2 cytokines were measured by ELISA and radioactive immune assay (RIA). The T lymphocyte subpopulation was detected by using fluorescence immunoassay. The similar indices taken from the healthy persons served as controls. RESULTS: The viral infection rate among IDUs was 36.45% for HBV, 69.7% for HCV, 47.3% for HIV, 2.22% for HDV, 1.97% for HGV, and 3.45% for HCMV. The co- infection rate of blood-borne virus was detected in 255 of 406 (62.81%) IDUs. More than 80% (161/192) of subjects infected with HIV were co-infected with the other viruses, such as HBV, HCV. In contrast, among the controls, the infection rate was 17.65% for HBV and 0% for the other viruses. Our investigation showed that there was a profound decrease in the proportion of CD4/CD8 and the percentage of CD3 and CD4, but not in the percentage of CD8. The levels of PHA-induced cytokines (IFN-γ and IL-4) and serum IL-2 were obviously decreased in IDUs. On the other hand, the level ofserum IL-4 was increased. The level of IFN-γ and the percentage of CD4 were continuously decreased when the IDUs were infected with HIV or HIV co-infection. IDUs with HIV and HBV co-infection was 15.1% (29/192). Of those 29 IDU with HIV and HBV co-infection, 51.72% (15/29) and 37.93% (11/29) were HBV-DNA-positive and HBeAg-positive, respectively. But, among IDUs without HIV infection, only 1.68% (2/119) of cases were HBV- DNA-positive. CONCLUSION: HCV, HBV and HIV infections are common i

关键词：静脉注射吸毒者血液传播病毒联合感染 T淋巴细胞亚群

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