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Gastro-electric dysrhythm and lack of gastric interstitial cells of cajal

World Journal of Gastroenterology 2004年第8期10卷 1227-1230页

作者： Qing-LinLong Dian-ChunFang Hong-TaoShi Yuan-HuiLuo GastroenterologyResearchCenter South-westHospitalThirdMilitaryMedicalUnivisityChongqing40038China

AIM:The pathophysiology underlying gastrointestinal complications of long-standing diabetes is poorly understood. Recent evidence suggests an important role of intestitial cells of cajal in controlling gastrointestinal *** aim of this study was to clarify the changes of ultrastructural characteristics of interstitial cells of cajal in stomach of diabetic gastro-electric dysrhythmic rats. METHODS:Rats were randomly divided into diabetic group and control group,the model of diabetic rats was established by peritoneally injection of *** were recorded and intestitial cells of cajal in antrum were observed by electrictelescopy after diabetic model rat was established for 3 mo. RESULTS:In the rats of diabetic group,the gastro-electric dysrhythmia was increased compared with control group, the abnormal rhythm index and the cofficient of variation of slow wave frequency were significantly higher than those of normal *** number of the gap junctions of interstitial cells of cajal in antrum of diabetic rats was significantly decreased,and the remaining structures were damaged. The organelles were also damaged,and vacuoles were formed. CONCLUSION:It is possible that changes in ultrastructural characteristics of interstitial cells of cajal in stomach are one of the mechanisms underlying gastro-electric dysrhythm in diabetic rats.

关键词：胃电功能紊乱胃间隙细胞病理机制动物模型糖尿病

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